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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 41 for “"small interfering RNAs"”.

  1. Roles of piwi-interacting RNAs and small interfering RNAs in regulating gene expression in Caenorhabditis elegans

    Reed, Kailee Janelle, author, Montgomery, Taiowa A., advisor, Wilusz, Carol J., committee member, Nishimura, Marc T., committee member, Hoerndli, Fred J., committee memberColorado State University. Libraries2022

    There are three distinct classes of small RNAs found in animals: microRNAs (miRNAs), piwi interacting RNAs (piRNAs), and small interfering RNAs (siRNAs). miRNAs are required throughout development, whereas piRNAs and siRNAs are best known for their roles in germline development and genome defense …

    colostate Repository record

  2. Characterization of the roles of Xrn1p in small-RNA-mediated gene-silencing pathways

    Getz, Matthew Aaron.Massachusetts Institute of Technology2019

    RNA interference (RNAi) is a small-RNA-mediated gene-silencing pathway that is involved in viral defense, transposon silencing, heterochromatin formation, and post-transcriptional gene silencing. Most RNAi pathways are initiated by long, dsRNA which is processed by Dicer into small interfering RNAs …

    mit Repository record

  3. FUNCTIONAL ANALYSIS OF THE UPSTREAM PSEUDOKNOT DOMAIN AND ITS SUBSTITUTION WITH A POLY(A) TRACT IN TOBACCO MOSAIC VIRUS (TMV)

    GUO SONG2015

    … BENTHAMIANA. DEEP SEQUENCING RESULTS SHOWED THAT SMALL RNA PROFILES DIFFERED BETWEEN TMV- AND TMV-43A-INFECTED PLANTS. SEVERAL VIRAL SMALL INTERFERING RNAS DERIVED FROM TMV-UPD WERE PREDICTED TO TARGET HOST GENES. RNA STRUCTURES WERE ANALYZED USING SELECTIVE 2'-HYDROXYL ACYLATION ANALYZED BY …

    nus Repository record

  4. RNAi-related genes in Toxoplasma gondii.

    Al Riyahi, AhmadUniversity of Windsor2005

    … homologous transcripts. Argonaute proteins and small interfering RNAs (siRNAs) are the known signature components of the RNAi effector complex, named RNA-induced silencing complex (RISC). Our group previously reported that dsRNA-induced specific gene silencing is functional in Toxoplasma gondii, …

    windsor Repository record

  5. Sulforaphane sensitizes TRAIL-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated upregulation of DR5

    김, 희수2006

    … by administration of a blocking antibody or small interfering RNAs for DR5. These results collectively indicate that SFN-induced generation of reactive oxygen species and the subsequent upregulation of DR5 are critical for triggering and amplifying TRAIL-induced apoptotic signaling. We also …

    ajou Repository record

  6. Loperamide enhances bortezomib-mediated cell death in colon cancer cells

    심, 민준2015

    … and mitochondrial Ca² levels 11 I. Small interfering RNAs 11 J. shRNA-mediated knockdown of proteins 12 K. Aggresome staining 12 L. Flow cytometry for the analysis of DNA contents 13 M. Clonogenic cell survival assay 13 III. RESULTS 14 1. Synergistic cell death induced by loperamide …

    ajou Repository record

  7. A survey of fly and nematode small RNAs by deep sequencing

    Ruby, J. Graham (James Graham)Massachusetts Institute of Technology2008

    Small RNAs of -22 nt length play a variety of roles in the biology of animals by repressing the translation or stimulating the degradation of complementary messenger RNAs. Depending on the structure of their precursors, they can be categorized as either microRNAs (miRNAs) or small interfering RNAs …

    mit Repository record

  8. Expression and function of small RNAs in normal and psoriatic skin

    Joyce, Cailin2013

    … mRNA transcript levels in psoriatic skin. microRNAs: miRNAs) are a class of short, regulatory RNAs that play critical roles in human development and disease. I hypothesized that differential expression of miRNAs might underlie some of the gene expression changes in psoriatic skin. Thus, I sought …

    wustl Repository record

  9. Exploiting entomopathogenic nematode neurobiology to improve bioinsecticide formulations

    Morris, RobQueen's University Belfast2020

    … be used to enhance their biocontrol efficiency. Small interfering RNAs can silence genes post transcriptionally. One method to achieve gene knockdown with small interfering RNAs is RNA interference (RNAi). RNAi is a powerful tool to determine the function of a gene, as it can be tailored to …

    qu-belfast Repository record

  10. Functional Characterisation of a Novel Tir-Domain containing Protein in Immune Signalling

    Horgan, AlanNational University of Ireland Maynooth2012

    … regulator of innate immune signalling. Small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) were used to suppress endogenous expression of IL-17RD leading to enhanced activation of NF-κB and NF-κB responsive genes by TLR ligands such as Lipopolysaccharide (LPS) and …

    maynooth Repository record

  11. Small RNA studies in Drosophila melanogaster, Stylophora pistillata and Symbiodinium sp.

    Liew, Yi JinUniversity of Cambridge2013

    Small non-coding RNAs such as microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs) play a big role in regulating gene expression in cells. In my work, I focus primarily on miRNAs, which represses the expression of the mRNA targets post-transcriptionally. For …

    cambridge Repository record

  12. Small non-coding RNA-mediated epigenetic regulation of gene expression and its implications for wheat adaptation to continuous cultivation

    Han, LingyueChristian-Albrechts-Universität zu Kiel

    … cultivation. Chapter III entitled "MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) facilitate the adaptation of wheat (Triticum aestivum L.) to continuous cultivation" demonstrates that both miRNAs and 24-nt siRNAs are strongly affected by continuous cultivation and act as key …

    cau-kiel Repository record

  13. West Nile virus versus the host cell: Identification of host factors that modulate infection

    Felicia Gilfoy Santa Maria GuerraThe University of Texas Medical Branch2008

    … essential for WNV infection and/or replication, small interfering RNAs (siRNAs) were used to systematically knockdown host gene products and levels of WNV infection and/or replication was assayed in the absence of these factors. A siRNA library screen identified ten cellular proteins which are …

    utmb Repository record

  14. Pathogenic Characterization and Therapeutic Development for Fiblrolamellar Hepatocellular Carcinoma

    Levin, Solomon N

    … therapy with antisense oligonucleotides and small interfering RNAs. I will close with a discussion on my thesis work and how I envision future research to continue from what I present here.</p>

    rockefeller Repository record

  15. Role of small RNAs and chromatin in transposable element silencing during global demethylation

    Berrens, Rebecca VUniversity of Cambridge2017

    … In this thesis, I investigate the role of small RNAs to control TEs during global waves of DNA demethylation in cellular reprogramming, naïve pluripotency as well as early mammalian development. Following an introduction to the research questions, in chapter 3 I investigate the mechanism …

    cambridge Repository record

  16. Inhibierung von Adenovirusinfektion mittels siRNA vermittelter Blockade adenoviraler Regulations- und Verpackungsgene

    Bode, Anne2016

    … kurze doppelsträngige RNA-Moleküle, die small interfering RNAs (siRNAs), im Zytoplasma die Bindung ihrer sequenzhomologen Ziel-mRNA und die darauffolgende enzymatische Spaltung. An vielen Beispielen wurde bereits gezeigt, dass sich virale Infektionen durch den Einsatz von synthetisch …

    fu-berlin Repository record

  17. INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE

    AURILIA, MIRIAMUniversità degli Studi di Milano2025

    … Gb3 accumulation, paving the way for new small-molecule therapies capable of penetrating the central nervous system. Thus, to find genes involved in Gb3 buildup, we performed a high-content imaging screen using a library of approximately 11,000 siRNAs (small interfering RNAs, which silence …

    milano Repository record

  18. HIV-1 Envelope-Induced Signaling Mediates Actin Cytoskeleton Rearrangements Necessary for Fusion and Entry

    Harmon, Brooke2013

    … and downstream of Rac activation, we utilized small interfering RNAs: siRNAs) and various small-molecule inhibitors to disrupt signaling pathways activated by HIV-1 Env through CD4 and coreceptors. Published data from our lab demonstrated that the G-alpha-q pathway, activated by CCR5, is …

    wustl Repository record

  19. The Mechanism of Double-Stranded RNA Response in Neurospora

    Choudhary, Swati2010

    … RGG domain, which is important for binding small interfering RNAs (siRNAs) and therefore required for its stability as well as efficient RNAi.

    utswmed Repository record

  20. Involvement of Translationally controlled tumor protein in Tomato yellow spot virus infection

    Andrade, Patrícia OliveiraUniversidade Federal de Viçosa2017

    … mechanism, leading to the production of small interfering RNAs (siRNAs) by the cleavage of Dicer proteins and the siRNAs generated might regulate the expression of host endogenous genes involves in virus infection. In silico analysis was performed to evaluate the possible siRNAs generated …

    brazil-ufv Repository record

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