Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 127 for “"small animal"”.
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A small-animal hospital
Thesis (M.Arch.) Massachusetts Institute of Technology. Dept. of Architecture, 1951.
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Improved quantification in small animal PET/MR
… and MR images to improve the quantification of small animal PET data. The primary focus was to improve image-based estimates of the arterial input function (AIF), which defines the amount of PET tracer within blood plasma over time. The AIF is required to produce physiological parameters …
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Proof-of-Concept For Converging Beam Small Animal Irradiator
… a high dose rate, high precision converging beam small animal irradiation platform.</p> <p>In the first aim of this work, a novel carbon nanotube-based compact X-ray tube optimized for</p> <p>high output and high directionality was designed and characterized. In the second aim, an</p> …
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Dispersal in small animal populations : a modeling approach to examine alternative hypotheses
Thesis (M.S.)--Michigan State University. Dept. of Fisheries and Wildlife,
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Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging
… using a single source and detector pair for small animal imaging. In our system, the intensity of laser source is modulated to produce a diffuse photon density wave in the tissue. The phase of the diffuse photon density wave is measured by comparing the reference signal with the signal from …
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Methods and technologies for high-throughput and high-content small animal screening
… high-content screening (HTS and HCS) of whole animals requires their immobilization for high-resolution imaging and manipulation. Here we present methods to enable HTS and HCS of the nematode Caenorhabditis elegans (C. elegans). First we present microfluidic technologies to rapidly isolate, …
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Improving attenuation corrections obtained using singles-mode transmission data in small-animal PET
… transmission scanning. Although suitable for small animal PET, these scans are subject to high amounts of contamination from scattered photons. Currently, no accurate correction exists to account for scatter in these data. The primary purpose of this work was to implement and validate an …
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High-field Cardiac Magnetic Resonance Imaging in Small Animal Models of Cardiovascular Disease
… in LV structure or function, relative to MI animals.CMRI was also used to assess the LV in rat model of MI following human induced pluripotent stem (hiPS) cell-derived cardiomyocyte therapy, in direct comparison to human MSC (hMSC) therapy. MI was induced by permanent ligation of the left …
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Development of a Three-Dimensional Image-Guided Needle Positioning System for Small Animal Interventions
Conventional needle positioning techniques for small animal microinjections are fraught with issues of repeatability and targeting accuracy. To improve the outcomes of these interventions a small animal needle positioning system guided by micro-computed tomography (micro-CT) imaging was developed. …
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Development and Commissioning of An Independent Peer Review System For A Small Animal Irradiator
<p>Dosimetry for small animal irradiators lacks the standardization of clinical radiotherapy practice, yet plays a central translational role in human trial design. The purpose of this work was to improve the dosimetric accuracy and consistency of animal studies by developing an independent peer …
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Methods and adaptations required to perform small-animal MRI scanning using a large bore clinical MRI
Small-animal imaging has been widely implemented to study succession of disease, therapeutic treatments and the effects of environmental insults. The gold standard noninvasive technique for following progression of heart failure in small-animal models is magnetic resonance imaging (MRI). The aim of …
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Hybrid pixel-waveform semiconductor detectors: novel detector readout for semiconductor pet imaging of small animal neurodegenerative models
… end, this work explores the potential use of small pixel hybrid pixel-waveform (HPWF) CdTe detectors for PET by experimentally evaluating common performance criteria such as timing resolution, energy resolution, and spatial resolution with efforts aimed at deconstructing the performance …
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USE OF NEAR-INFRARED FLUORESCENCE WITH INDOCYANINE GREEN IN SMALL ANIMAL SURGICAL ONCOLOGY AND IN CADAVERIC ANATOMICAL STUDY
… precision and intraoperative decision-making in small animal surgical oncology. This PhD project investigates the use of NIRF-ICG imaging to address key challenges in surgical oncology in dogs and cats. The research is structured into three main lines of investigation: 1. the use of NIRF-ICG for …
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Pichinde virus infection of outbred Hartley guinea pigs and mice as small animal models of human Lassa fever
… describes two studies that use two different small animal models of infection with the Pichinde virus as surrogate models of human Lassa fever that can be carried out in a conventional (BSL2 level) laboratory, as Pichinde virus is non-pathogenic in humans. The first study uses mice that are …
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Structural and functional imaging of the human and small animal eyes using ultrahigh speed Fourier domain optical coherence tomography
… ophthalmic imaging techniques for the human and small animal eyes are investigated using ultrahigh speed Fourier domain OCT. The following topics are discussed: (1) a method for numerically extracting and compensating dispersion mismatch in ultrahigh resolution spectral domain OCT, (2) ultrahigh …
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Application of a High‑Resolution Computed Radiography System in Detecting an Iodinated X‑ray Contrast Agent: Small Animal Phantom Study
… iodinated contrast agent, in a phantom mimicking small animal tumor model.</p> <p>The first phase of the project was dedicated to a comprehensive assessment of CR image quality by measuring presampled Modulation Transfer Function (MTF), Noise Power Spectrum (NPS), Relative Standard Deviation of …
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Preliminary evaluation of X-ray fluorescence imaging and ultra-high resolution CdTe PET: the progression toward broader spectrum multi-modality tools for small animal neuroscientific investigation
… by the instruments available for exploring the small animals, generally mice, involved in the experiments. Nuclear instruments such X-ray, Positron Emission Tomography (PET), and Single Photon Emission Computed Tomography (SPECT) are often implemented due to their ability to identify either the …
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