Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 150 for “"small RNA"”.
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Analysis of soybean small RNA populations
Made available in DSpace on 2012-02-01T00:55:15Z (GMT). No. of bitstreams: 3 Win_Hlaing.pdf: 2806604 bytes, checksum: fd83d1b127a3edbf2c2b5d09055f19d1 (MD5) license.txt: 4057 bytes, checksum: bfab5ce9051b73addae93f75bad9bb47 (MD5) Win_Hlaing.docx: 2620656 bytes, checksum: …
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Small RNA-based antiviral defense in insects
Contains fulltext : 131645.pdf (Publisher’s version ) (Open Access)
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Understanding the physiological role of the small RNA RydC
… aims to understand the physiological role of the small RNA (sRNA) RydC and the signals controlling RydC production. RydC was previously shown to stabilize cfa (cyclopropane fatty acid synthase) mRNA, resulting in higher levels of cyclopropane fatty acids in the cell membrane. Here, we show that …
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Small RNA and genome interactions in Chlamydomonas reinhardtii recombinants
… in the formation of transgressive phenotypes. RNA silencing is an epigenetic mechanism of gene regulation relying on 20Q24nt single stranded small RNAs (sRNAs). Small RNAs, due to their ability to set up persistent epigenetic marks at a locus, have the potential to create heritable …
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Sequence and structure requirements of Y RNA-derived small RNA biogenesis
Numerous small non-coding RNAs have been identi�ed in mammalian cells, including microRNAs and piwi-interacting RNAs. The patterns of gene expression within cells can be altered in response to cellular stress. To examine the e�ects of cellular stress on all small RNA types, a number of human cell …
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Novel Small-RNA Mediated Gene Regulatory Mechanisms for Long-Term Memory
… of gene expression. To explore the role of small RNAs in memory-related synaptic plasticity we carried out massive parallel sequencing to profile the small RNAs of Aplysia. We identified 170 distinct 21-23 nt sized miRNAs, 13 of which were novel and specific to Aplysia. Nine miRNAs were …
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Regulation of the Mannose PTS Operon by the small RNA SgrS
A number of bacterial small RNAs (sRNAs) act as global regulators of stress responses by controlling expression of multiple genes. The sRNA SgrS is expressed in response to glucose-phosphate stress, a condition associated with disruption of glycolytic flux and accumulation of sugar-phosphates. SgrS …
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Human colon cell migration and socialization induced by small RNA nucleotides
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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An E. coli small RNA inhibits translation initiation from a distance
In bacterial systems, small RNA (sRNA)-dependent translational repression is commonly carried out via sRNA-mRNA base pairing interactions near the Shine-Dalgarno (SD) region. In this so-called “canonical” mechanism, the sRNA is the direct regulator; it competes with the initiating ribosomes while …
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Small RNA studies in Drosophila melanogaster, Stylophora pistillata and Symbiodinium sp.
Small non-coding RNAs such as microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs) play a big role in regulating gene expression in cells. In my work, I focus primarily on miRNAs, which represses the expression of the mRNA targets post-transcriptionally. For …
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Small RNA and A-to-I editing in Autism Spectrum Disorders
… goal, we surveyed adenosine-to-inosine (A-to-I) RNA editing in autistic brains. A-to-I editing is an epigenetic mechanism that fine-tunes synaptic function in response to environmental stimuli, shown to modulate complex behavior in animals. We used ultradeep sequencing to quantify A-to-I recoding …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
We have identified and characterized the first sRNA, DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the …
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A small RNA regulates RpoS in the Lyme disease spirochete Borrelia burgdorferi
We have identified and characterized the first sRNA, DsrABb, in the Lyme disease spirochete, <em>Borrelia burgdorferi</em>; as well as, identified a non-canonical RNA chaperone Hfq. The alternative sigma factor RpoS (sigma 38 or sigma S) plays a central role in the reciprocal regulation of the …
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Quality checking and expression analysis of high-throughput small RNA sequencing data
The advent of high-throughput RNA sequencing (RNA-seq) methods have made it possible to sequence transcriptomes for the cell-wide identi�cation of small non-coding RNAs (sRNAs) and to assess their regulation using di�erential expression analysis by comparing two or more di�erent conditions. During …
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Target regulation and prioritization by the small RNA SgrS in Escherichia coli
Regulation of gene expression by small non-coding RNAs is ubiquitous in all domains of life. In bacteria, small RNAs are known regulators of various stress responses. Diverse mechanisms employed by small RNAs demonstrate multi-faceted nature of gene regulation, tailored to respond to stress with …
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Characterization of the roles of Xrn1p in small-RNA-mediated gene-silencing pathways
RNA interference (RNAi) is a small-RNA-mediated gene-silencing pathway that is involved in viral defense, transposon silencing, heterochromatin formation, and post-transcriptional gene silencing. Most RNAi pathways are initiated by long, dsRNA which is processed by Dicer into small interfering RNAs …
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Investigation Of X Chromosome Recognition: The Role Of Small Rna In Drosophila Dosage Compensation
… complex, which consists of two large, non-coding RNA on the X transcripts (<i>roX1</i> and <i>roX2</i>) and five proteins. The roX RNAs have a critical role in complex localization to the X chromosome. Simultaneous mutation of <i>roX1</i> and <i>roX2</i> reduces X localization of the MSL proteins, …
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Molecular analysis of small RNA and small protein regulation of Escherichia coli stress responses
Small RNA (sRNA) regulators control gene expression throughout all domains of life. In bacteria, they typically affect virulence, metabolism, and stress response genes posttranscriptionally through imperfect antisense pairing with their mRNAs. While most sRNAs are non-coding, a small number act as …
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Sweet relief: regulating the response to glucose phosphate stress by the small RNA SgrS & Co.
… (i.e., phosphosugar stress) by producing a small RNA (sRNA) regulator, SgrS, which represses translation of sugar transporter mRNAs (ptsG and manXYZ) and enhances translation of a sugar phosphatase mRNA (yigL). Despite a molecular understanding of individual target regulation by SgrS, …
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Initiation of translation of the small RNA of the cowpea strain of tobacco mosaic virus
… of the initiation of translation of CcTMV-SRNA were investigated. First, the site of initiation of translation was found to be the first AUG in the 5$\sp\prime$-terminal sequence m$\sp7$GpppGUAUUUGAUGAUGGCA ... despite the fact that this AUG codon is not found within a favorable PuXXAUGG …
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