Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"small GTPase"”.
-
Nanoscale Organization of The Small Gtpase Rac1
<p>Rac1 is a small, guanine-nucleotide binding protein that cycles between an inactive GDP-bound and active GTP-bound state to regulate actin-mediated motility, migration, and adhesion. Plasma membrane (PM) localization is essential for its biological activity. Rac1 PM targeting is directed by a …
-
Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
<p>Activation of Rho family small G proteins is thought to be a critical event in breast cancer development and metastatic progression. Rho protein activation is stimulated by a family of enzymes known as guanine nucleotide exchange factors (Rho GEFs). The neuroepithelioma transforming gene 1 …
-
The Small GTPase Rheb Is Required for Spermatogenesis but not Oogenesis
… to evaluate the role of Rheb, a member of the small GTPase superfamily and a critical component for mTORC1 activation, in male and female gametogenesis. The function of Rheb in development and the nervous system has been extensively studied, but little was known about its role in the germline. …
-
Identification and Characterization of Effectors/Binding Molecules for the Small GTPase Rab15
… the pericentriolar recycling\r\nendosome. Rab GTPases regulate specific membrane trafficking steps including vesicle\r\nbudding, vesicle transport and fusion with downstream target compartments. Rab\r\nfunction is mediated by the cyclical binding and hydrolysis of GTP, which in …
-
Endosomal membrane dynamics underlying cell spreading: A role for the small GTPase Arf6
… in turn, implicated functions of a variety of small GTPases of the Ras superfamily, which include the Rho and Arf subfamilies. Thus towards efforts of further characterizing the molecular pathways that drive cell spreading, I pursued aims to examine the role of a specific member of the Arf …
-
Modulation of the Hippocampal Neurogenic Program by the Circadian Clock Machinery and the small GTPase, Rasd1/ Dexras1
… neurogenic program: the circadian clock and the small GTPase, Dexras1. The circadian clock machinery controls daily timings in cellular events via the transcription-translation feedback loop (TTFL), which includes Bmal1 and Period2. In this thesis, I demonstrate the presence of the molecular …
-
Regulation of Growth and Development by the Small GTPase Cdc42p and the Transcription Factor Tec1p in <i>Saccharomyces cerevisiae</i>
… in der Hefe untersucht. Die kleine GTPase Cdc42p ist ein essentielles Protein. Es fungiert als molekularer Schalter, der zwischen einer aktiven, GTP-gebundenen und einer inaktiven, GDP-gebundenen Konformation wechselt. In der aktiven Form interagiert Cdc42p mit einer Reihe von …
-
Rab8 Directs Tubulation and Furrow Ingression During Epithelial Formation in Drosophila Melanogaster
… unclear. This research shows that Rab8, a small GTPase associated with late exocytic trafficking events, demonstrates striking dynamic behaviors <em>in vivo</em>; transitioning from punctate structures to a stable association with the cortex during furrow formation. Active, GTP-locked Rab8 …
-
Identification of genotype-specific dependencies in Keap1-deficient lung adenocarcinoma
… has identified activating mutations in the small GTPase, KRAS, encompassing ~30% of all LUAD patient samples. Efforts in therapeutic intervention for KRAS-mutant LUAD are numerous, but have been met with little clinical success. Importantly, large-scale sequencing studies have defined the …
-
Characterization of perillyl alcohol as a cell migration-inhibiting compound
… we examined the loss of prenylation of RhoA, a small GTPase protein involved in the formation of focal adhesions and stress fibers, and corresponding morphological changes following exposure to perillyl alcohol.
-
Targeting Thromboxane A2 Receptor Signaling in Breast Cancer Metastasis
… of this receptor elicits rapid activation of small GTPase RhoA and cytoskeleton reorganization. We also found that knockdown of TP expression or inhibition of TP activation by SQ29548, a TP antagonist, reduces tumor cell motility, reduce tumor cell extravasation from the circulatory system, …
-
Beach1 functionally antagonizes Rab11 during development and in regulating synaptic morphology
… beach1 eye overexpression phenotype. Rabll is a small GTPase, which has been shown to regulate the delivery of vesicles and cargo to the plasma membrane via both the recycling and the biosynthetic pathways. Although beach1 loss-of-function mutants exhibit no obvious phenotypes, a sensitized …
-
Targeting Plasma Membrane Phosphatidylserine Content to Inhibit Oncogenic Kras Function
<p>The small GTPase KRAS, which is frequently mutated in human cancers, must be localized to the plasma membrane (PM) for biological activity. We recently showed that the KRAS C-terminal membrane anchor exhibits exquisite lipid-binding specificity for select species of phosphatidylserine (PtdSer). …
-
Biophysical and computational insights into the stability of RhoB and its cancer-associated variants
RhoB is a small GTPase, part of the Rho family of the Ras superfamily of small G proteins, that act as cellular signalling switches. RhoB is involved in regulating the cytoskeleton, angiogenesis, cell death, endosome trafficking and DNA damage repair. Unlike other small GTPases such as K-Ras, RhoA …
-
Functional Protein Delivery Using Polymeric Nanoparticles: A Novel Therapeutic Approach to Alpha-Synuclein Aggregation and Parkinson's Disease
… of nanoparticle degradation. Delivery of the small GTPase rhoG induces neurite outgrowth and differentiation in PC12 cells. In addition, a monoclonal antibody (H3C) directed against the C-terminus of synuclein is capable of interacting with endogenous alpha-synuclein (alpha-syn) in neurons …
-
Spatiotemporal organization, regulation and function of traction during neutrophil chemotaxis
… II activation induced by spatially activated small GTPase Rho and its downstream kinase p160-ROCK, as previously reported, leads to contraction of actin-myosin II complexes at the trailing edge, causing it to de-adhere. Our data identify a key biomechanical mechanism for persistent cell …
-
MECHANO-CHEMICAL FEEDBACK VIA CONTACT PERCOLATION REGULATES PHASE TRANSITION AND TRANSCRIPTIONAL STATE IN HETEROGENEOUS BREAST CANCER
… recently demonstrated that RAB5A, an endocytic small GTPase, induces tissue fluidification, promotes BC progression, and triggers an inflammatory gene response via cGAS/STING pathway and the acquisition of malignant traits. While prior studies used genetically homogeneous models, BC exhibits …
-
Catalysis of tubulin heterodimerization in vivo
… data suggesting that Cin4p, an ARF family GTPase, associates with the tubulin cofactor Cin1 p (cofactor D) and promotes tubulin heterodimerization by modulating Cin1 p's association with β-tubulin. Through site-directed mutagenesis, we conclude that Cin4p GTPase activity is important for …
-
Shield and Shuttle: Importins as Protective Chaperones and the Nuclear Transport Mechanism of H2A-H2B
… release from the Importin is facilitated by a small GTPase, Ran, bound to GTP. Interestingly, there have been many biochemical experiments showing that RanGTP binding is not enough for cargo release of histones H2A-H2B and transcription factors TBP and TFIIB for yeast Importin Kap114. It has …
Page 1 of 4