Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"slow-cycling"”.
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Utopias of slow cycling : imagining a bicycle system
… urban mobilities and catalyse change towards slow living. Drawing upon readings in mobility and utopian studies, the thesis considers three complementary aspects that could be decisive in the transition towards a 'slow bicycle system'. I investigate first the potential of embodied and sociable …
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Specification And Function Of Early Hair Follicle Stem Cells
… to identify putative stem cells based on slow-cycling character. Slow-cycling cells appeared early in follicle development, where they expressed numerous SC markers, and later gave rise to the adult bulge SC population. Furthermore, early slow-cycling cells displayed a similar pattern of …
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Development and Maintenance of Thymic Epithelial Microenvironment
… transgenic model to identify a slow cycling potential stem cells/progenitor population in the postnatal thymus. These cells were isolated, expanded in culture, and successfully differentiated into adipocytes, chondrocytes and osteoblasts. We identified that the culture expanded …
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The chronic response to centrosome loss-induced cell cycle exit
… is due to cellular heterogeneity or a globally slow-cycling state, I have taken a single-cell transcriptomics approach and found that long-term centrinone treatment results in two distinct sub-populations, one exhibits typical senescence features, the other appears to maintain proliferative …
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A Continental-Scale Investigation of Factors Controlling the Vulnerability of Soil Organic Matter in Mineral Horizons to Decomposition
… decomposition rates of fast- (kfast) and slow-cycling pools (kslow). Post-LASSO best subsets multiple linear regression was used to construct horizon-specific models of significant predictors for CSR, kfast, and kslow. Significant predictors for all three response variables consisted …
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A SEARCH FOR EPIGENETIC VULNERABILITIES OF AML CELLS PERFORMED BY A CDK INHIBITOR¿BASED CRISPR SCREENING
… reprograms the chromatin landscape of fast-cycling AML cells resistant to LSD1 inhibition, rendering them more similar to slow-cycling counterparts that are intrinsically sensitive to LSD1 inhibition. This finding suggested that cell cycle dynamics critically influence the response to …
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Modeling Epithelial Ovarian Cancer In The Mouse
… and advances in treatment approaches have been slow. Deficiency of tumor suppressor genes p53 and RB and overexpression of c-MYC oncogene occur frequently in the most common form of sporadic EOC, high grade serous adenocarcinoma. Thus, we have initiated development of several mouse models of EOC …
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Phenotypic heterogeneity in high-grade serous ovarian cancer: evidence for a stochastic model of proliferation
… deficient in EpCAM is seen to divide more slowly in all cases. Both subpopulations divide stochastically, and their rates of proliferation match the expansion of each subpopulation. This indicates that both subpopulations are self-supporting. Inducible lineage tracing tools were validated …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… Recent evidence has revealed the existence of slow-cycling persister cells that survive drug treatments and give rise to multi-drug tolerant mutants in cancer. The mechanisms associated with persister phenotypes are highly diverse and complex, and many aspects of persister cell physiology …
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Investigating intratumoural heterogeneity and plasticity with multiplexed single-cell assays
… response to KRAS inhibition. Cells have a slow-cycling and hybrid phenotype after KRAS inhibition which are reminiscent of developmental programs found in the healthy colon. I propose a preliminary model of how CRC cells adapt to KRAS inhibition over time. Finally, I summarize my Thesis …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
… expressed in human glioblastoma cells that are slow-cycling and express genes characteristic of mammalian NSC quiescence. Glioblastoma is a cancer with poor prognosis, as chances of tumour recurrence are high. This may be due to the presence of a subpopulation of cancer stem cells which divide …
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Metabolic Pathways of Amino Acids, Monosaccharides and Organic Acids in Soils assessed by Position-Specific Labeling
… simultaneously. This involved an intensive C recycling and turnover within the microorganisms that was observed not only for cytosolic compounds but also for cell wall polymers. Intensive modifications and transformation within metabolic side branches, like the fatty acid formation and …
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New insights into cornea-lens regeneration in Xenopus laevis: the role of Wnt/beta-catenin signaling and the regenerative capacity of the limbal region
… post-metamorphic Xenopus cornea, consistent with slow-cycling stem cells of the limbus that have been described in other vertebrates. Additionally, the pattern of label being lost from the central cornea is consistent with a model of centripetal migration of cornea epithelial cells away from the …