Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"slit diaphragm"”.
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Phase Transitions of Multivalent Adaptor Proteins
… example of proteins involved in creating the slit-diaphragm, which is the filtration barrier of our kidneys. Nephrin, an integral membrane protein at the slit-diaphragm, interacts with its partners Nck and N-WASP in a multivalent fashion. I show here that these interactions create large …
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Significance of α-Lipoic acid on cell viability and nephrin in human podocytes under normal and high glucose conditions
… found to maintain integrity and function of the slit diaphragm. Additionally, nephrin phosphorylation mitigates stress in hPC. α-Lipoic acid (α-LA) is a naturally occurring compound, also licensed for the treatment of diabetic neuropathy in Germany. We aimed to investigate whether α-LA affects …
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Nephrotic Syndrome and Glomerular Basement Membrane: Genetic Defect of the Laminin α5 Chain
… of proteins playing a crucial role in slit diaphragm signalling, regulation of actin cytoskeleton dynamics and cell-matrix interactions. <br></br><br></br> The laminin α5 chain is a 404 kDa protein essential for embryonic development and, in association with laminin β2 and laminin γ1, …
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Characterization of signaling pathways regulating nephrin endocytosis in kidney podocytes: novel roles for Nck and ShcA adaptor proteins
… projections termed foot processes. The slit diaphragm is a molecular barrier that lies laterally between foot processes and acts as a discerning filtration pore. Nephrin is a key component of this barrier and disrupted nephrin trafficking is suggested to be a source of filtration …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… disruption of the podocin-TRPC6 complex at the slit diaphragm contributes to Ca2+ overload and eventual foot process effacement. Drugs that selectively target and suppress TRPC6 mechanosensitivity could potentially serve as treatments for glomerular diseases.
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… by C21. Moreover, the expression of glomerular slit diaphragm proteins (nephrin and podocin) the estimated glomerular filtration rate remained unaffected which together suggest that HSD intake caused tubular proteinuria. The in vivo findings in megalin recycling impairment were confirmed by the …
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Neph-Proteine interagieren mit dem Multiadapterprotein ZO-1
Die Studie hereditärer Erkrankungen des glomerulären Filters der Niere hat zu einem dramatischen Wissenszuwachs und einem komplett neuen Verständnis der Funktion des Nierenfilters und der Entstehung des nephrotischen Syndroms geführt. Neph-Proteine wurden als Proteine der Schlitzmembran des …