Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"sleeping sickness"”.
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A Pharmacological Strategy Against African Sleeping Sickness
… the causal agent of the disease known as African sleeping sickness, transmitted via the bite of a tsetse fly. If left untreated, the parasite ultimately crosses the blood-brain eventually leading to death. Currently there are 5 approved drugs used to treat it, each with toxic side effects and …
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The role of host cues in the transmission of sleeping sickness
Tsetse (Glossina spp.) transmit species of Trypanosoma which cause trypanosomiases in livestock and humans. To improve the cost-effectiveness of baits used to control tsetse, studies were made of the host-oriented behaviour of the following Palpalis-group species: Glossina tachinoides and G. …
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Spatial epidemiology of Rhodesian sleeping sickness in recently affected areas of central and eastern Uganda
The tsetse transmitted fatal disease of humans, sleeping sickness, is caused by two morphologically identical subspecies of the parasite T. brucei; T. b. rhodesiense and T. b. gambiense. Current distributions of the two forms of disease are not known to overlap in any area, and Uganda is the only …
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Molecular epidemiology of trypanosomiasis in Ugandan cattle during the Stamping Out Sleeping Sickness control programme, 2006 – 2008
… of trypanosome in a newly endemic area of human sleeping sickness. Crucially the findings illustrate mass drug treatment is effective in reducing the prevalence of T. b. rhodesiense in cattle, thus minimising the reservoir potential of these animals in the epidemiology of human disease. During …
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Loop-mediated isothermal amplification (LAMP) for the diagnosis of human sleeping sickness: towards a point-of-care diagnostic test
Acute and chronic sleeping sickness are fatal neglected tropical diseases caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense respectively (members of the sub-genus Trypanozoon). Accurate diagnostics are needed to guide treatment since the symptoms of disease are non-specific …
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The role of transition fibre proteins in regulating CEP164C assembly and localisation to the flagellum in the African Sleeping Sickness parasite Trypanosoma brucei
Introduction: This study investigates the hypothesis that four transition fibre proteins, TFP122, TFP39, TFP104, and CEP90, regulate CEP164C recruitment to control flagellar assembly and length in Trypanosoma brucei, a paristie responsible for African trypanosomiasis. We focus on proteins within …
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Nitroaromatic pro-drug activation and resistance in the African trypanosome
Sleeping sickness, caused by Trypanosoma brucei, is a deadly disease that affects some of the poorest countries in sub-Saharan Africa. Although the disease prevalence is declining, strengthening of the current control efforts, including introduction of more adequate chemotherapeutic options, is …
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Published papers
… (T. nigeriense, n. sp . ) from a Case of Sleeping Sickness from Eket, Southern Nigeria. • 5. On the Pathogenicity of the Trypanosome (T. nigeriense) from a Case of Sleeping Sickness from Eket, Southern Nigeria. • 6. Preliminary Note on the Development of a Human Trypanosome in the Gut of …
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Some clinical observations on trypanosomiasis rhodesiensis
… the study of 94 consecutive cases of Rhodesian Sleeping Sickness.
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Small molecule inhibitors of parasitic enzymes
… from the causative agents of Malaria, African sleeping sickness and Chagas disease, (ii) development of potential new and novel anti-trypanosomal inhibitors of trypanosome alternative oxidase, and (ii) synthetic and methodological studies.
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Structure- based inhibitor design for key enzymes of <em>Tryposoma brucei</em>
… African trypanosomiasis (HAT) also known as sleeping sickness is caused by a subspecies of <em>Trypanosoma brucei</em>. These parasites are transmitted by tsetse flies and endanger over 60 million people in Sub-Saharan Africa. Untreated, sleeping sickness is fatal, causing at least 48.000 …
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Developing New Chemotherapeutic Agents Against Bone Resorption and Parasitic Diseases Through Computer -Aided Drug Design
… brucei, the causative agent of African sleeping sickness. These predictive models aid in optimizing existing inhibitors and ultimately designing novel ones.
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Synthetic strategies for potential trypanocides
Human African trypanosomiasis (sleeping sickness) is a devastating disease which is endemic in parts of sub-Saharan Africa. It is caused by the protozoan parasite T. brucei, which are transmitted by the bite of infected tsetse flies. Although the disease is fatal if left untreated, there is a lack …
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RNA genome annotation with a focus on T. brucei
… organism, and as the cause of African sleeping sickness -- which infects 300,000-500,000 people and a significant number of cattle annually -- is currently the subject of considerable research. Using existing algorithms, several patterns have been found that may lead to more complete …
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Canada's Contribution to Neglected Tropical Disease Research: A Co-authorship Network Analysis
… researchers specialize in Leishmania and African sleeping sickness research and are mainly affiliated with academic institutions within Canada (McGill University, Laval University and University of British Columbia). International co-authorship activity is largely with OECD countries (United …
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New Chemotherapeutic Approaches for the Treatment of Parasitic Protozoan Diseases
… These parasites are responsible for African sleeping sickness, South American trypanosomiasis (Chagas' disease), toxoplasmosis, leishmaniasis, and malaria, respectively. The studies contained within this thesis were carried out in three main areas: (a) demonstration of selective …
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Proteomic analysis of protein complexes and cell cycle regulation in <i>Trypanosoma brucei</i>
… protozoan parasite and the etiological agent of sleeping sickness in sub-Saharan Africa. The trypanosomatid order also includes the parasites <i>Trypanosoma cruzi </i>(Chagas disease) and <i>Leishmania major</i> (Leishmaniasis). Sleeping sickness is estimated to cause ~10,000 deaths per year and …
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Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes
… African trypanosomiasis (HAT), also known as sleeping sickness, has been a major health problem for populations in Africa caused by the Trypanosoma brucei spp parasite. Although, the current number of the reported cases is on the decrease, more efforts are required to try to control or …
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Discovery and development of diagnostic biomarkers for human African trypanosomiasis
<p>Human African Trypanosomiasis (HAT) or African Sleeping Sickness is a disease prevalent in many parts of Sub-Saharan Africa. HAT is a parasitic infection caused by two species, <em>Trypanosoma brucei gambiense</em> and <em>T. b. rhodesiense</em>. Clinical diagnosis is not sufficient as symptoms …
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Total Synthesis of the Actinoallolides and a Designed Photoaffinity Probe for Target Identification
… agents of human African trypanosomiasis (sleeping sickness) and Chagas disease, while exhibiting no observable cytotoxicity against the MRC-5 human cell line. The side effects associated with most current antitrypanosomal drugs mean that there is an urgent need for new and effective …
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