Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"skin tumor"”.
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Targeting Akt/Mtor Signaling Pathways During Murine Skin Tumor Promotion and The Impact of Dietary Energy Balance Manipulation
… across a broad range of species and tumor types. Previous data has demonstrated differential signaling through Akt and mTOR via the IGF-1R and other growth factor receptors across the diet-induced obesity (DIO)/CR spectrum. Furthermore, mTORC1 is known to be regulated directly via …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… human cancers and murine mouse models of tumorigenesis. Previous studies from our lab and others have established a critical role for Stat3 in epithelial tumorigenesis, but the role of Stat1 is largely unknown. The current study was designed to explore the role of Stat1 during multistage …
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The Role of Erbb2 in Ultraviolet-Induced Nonmelanoma Skin Carcinogenesis
… introduction - no abstract provided) Nonmelanoma skin cancer is more common than all other forms of cancer combined and its incidence is increasing. Most of these cancers are caused by UV, which has many effects on the skin. The RTK Erbb2 is activated by UV and is overexpressed in some skin …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
Non-melanoma skin cancers, the most common cancers in the United States, result from chronic exposure to ultraviolet irradiation (UV). UV-induced DNA damage activates cell cycle checkpoints through a mechanism involving degradation of the cyclin dependent kinase activators, the cell division cycle …
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Understanding Nanog'S Role In Cancer Biology
… PhD</p> <p>The cancer stem cell model holds that tumor heterogeneity and population-level immortality are driven by a subset of cells within the tumor, termed cancer stem cells. Like embryonic or somatic stem cells, cancer stem cells are believed to possess self-renewal capacity and the ability to …
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Role of Stat3 In Keratinocyte Stem Cells During Skin Tumorigenesis
… X Stat3<sup>fl/fl </sup>mice led to decreased tumor development by altering survival of bulge region KSCs. To further understand the role of KSCs in skin tumorigenesis, K5.Stat3C transgenic (Tg) mice which express a constitutively active/dimerized form of Stat3 called Stat3C via the bovine …
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Studies of tumor promoters and drug-metabolic enzymes in hamster buccal pouch mucosa
Lack of tumor promoters has been the major obstacle in the use of the hamster buccal pouch mucosa (HBPM) model. Two experiments were designed to investigate the effects of two new mouse skin tumor promoters, okadaic acid (OA) and methyl methanesulfonate (MMS), on HBPM. Short term effects of OA were …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
… a receptor tyrosine kinase, regulates both skin biology and carcinogenesis. We hypothesized that EGFR-dependent signal transduction increases normal keratinocyte proliferation and proliferation in response to ultraviolet (UV) irradiation, resulting in increased skin tumor growth. The …
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Stellenwert der optischen Kohärenztomographie in der Beurteilung epithelialer Hauttumoren : eine offene klinische Studie zur nicht-invasiven In-vivo-Anwendung der optischen Kohärenztomographie
The epithelial skin tumors and preinvasive lesions became an increasingly important due to rising incidence in the last few years. The determination between preinvasive and initially invasive lesions and presentation of tumor margins are conditions for apply of non-invasive therapies. Since 1995 …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… is a serine protease and a pivotal regulator of skin desquamation, the physiological process of skin renewal (Brattsand et al., 2005; Borgoño et al., 2007). KLK5 is activated autocatalytically (Michael et al., 2005) and then, it activates other downstream proteases that are expressed in the …