Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 144 for “"skin secretion"”.
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Discovery of bioactive peptides from amphibian skin secretion
… Among these, bioactive peptides in special skin secretions produced by frogs have been considered to be one of the rich natural sources for developing new drugs in the future.<br/><br/>In this thesis, several bioactive peptides were identified from the skin secretions of frogs by using …
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Bioactive peptides from the skin secretion of Kassina senegalensis
Bioactive peptides in amphibian skin have been reported to have various pharmacological activities. The discoveries of these peptides have become hot spots in the development of new drugs.<br/><br/>In Chapter 3, peptides QUB-1641, QUB-1746, Kassinakinin S and Senegalin were isolated from Kassina …
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Novel bioactive peptides from the defensive skin secretion of Phyllomedusinae frogs
Amphibian skin secretion contains a variety of bio-components, of which bioactive peptides are predominant. They produce such peptides to protect themselves from the threats in their environment like predatory attack and microorganism invasion. Antimicrobial peptides (AMPs) act as the first line of …
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Discovery and design of novel bioactive peptides from amphibian skin secretion
In this thesis, molecular cloning techniques were used to obtain the sequences of natural antimicrobial peptides and their synthesis was achieved using solid-phase synthesis (SPPS). In addition, the peptides were purified and identified by high-performance liquid chromatography (HPLC) and MALDI-TOF …
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A novel bioactive peptide from the skin secretion of Rana chensinensis
… from AMPs. A novel AMP was identified from the skin secretion of Rana chensinensis by molecular cloning. The peptide encoding cDNA was successfully sequenced via bioinformatics tools, which revealed that the peptide is a member of temporin family, with the mature peptide sequence as …
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A novel bioactive peptide from the skin secretion of Hylarana nigrovittata
The skin secretions of amphibians attract much attention due to the rich biologically active compounds contained in them. Many peptides from the skin secretions of amphibians have been found to have antimicrobial and enzyme inhibitory effects. In order to identify a new peptide from the skin …
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QUB-2577: A Bioactive Peptide from Pickerel Frog (Rana palustris) Skin Secretion
The skin of a frog is an important organ with a complex structure, which can play an important role not only in developing adaptation to the complex environment but also in preventing infection by microorganisms. Skin secretion of frogs contains a large number of antimicrobial peptides (AMPs) and …
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A bioactivity peptide QUB2852 from the frog skin secretion of pelophylax nigromaculata
… study, the AMP QUB-2852 was identified from the skin secretion of pelophylax nigromaculata through cloning of its precursor-encoding cDNA from a skin secretion-derived cDNA library by using a 3'-rapid amplification of cDNA ends (RACE) “shotgun” strategy. Subsequently, the mature peptide sequence …
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QUB-1073: a bioactive peptide from the skin secretion of Phyllomedusa rohdei
… of a bioactive peptide (QUB-1073) from the skin secretion of Phllomedusa rohdei and to determine the pharmacological activity on rat uterus and urinary bladder smooth muscle. <br/>A variety of biologically active peptides, including some new antimicrobial peptides and neuropeptides, have …
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Assessing bioactivity of a peptide from the skin secretion of Rana amurensis
… in various amphibians, especially form the skin secretions of the frogs. Furthermore, some studies have proven that many AMPs exhibit potent antimicrobial or anticancer activities, which has attracted increasing interest from researchers studying novel drug leads.<br/><br/>In this study, …
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A novel bioactive peptide from the defensive skin secretion of Phyllomedusa sauvagii
Amphibian skin contains large amounts of compounds which have biological activities. The research and exploitation of the peptides in amphibian skin secretions with antimicrobial or haemolytic activities has become increasingly popular. Many studies show that the antimicrobial peptides (AMPs) …
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A novel dermaseptin peptide from the defensive skin secretion of Phyllomedusa camba
… dermaseptin peptides have been isolated from the skins or the skin secre-tions of Phyllomedusa species and other related frogs and they all possess strong an-timicrobial activity with little or no haemolytic activity, which made it possible for the dermaseptin peptides to be considered for …
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QUB-1985: a bioactive peptide from the frog skin secretion of Odorrana livida
… precursor was isolated and identified from the skin secretion of the wild green mountain frog, Odorrana livida, with the assistance of shotgun cloning. The obtained mature peptide consists of 21 amino acid residues, GLLSGILGVGKKIVCGLSGLC, and this peptide was named QUB-1985 according to its …
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A bioactive peptide from the frog skin secretion of Pelophylax nigromaculatus GAPKGCWTKSYPPKPCS-NH2
… a Bowman–Birk type protease inhibitor, from the skin secretion of the frog Pelophylax nigromaculatus. The precursor was obtained from the Pelophylax nigromaculatus skin secretion by employing molecular cloning. The corresponding mature peptide, namely QUB-1804, was identified by bioinformatics …
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QUB-1439: A bioactive peptide from the frog skin secretion of Hylarana guentheri
… peptide (QUB-1439) which was isolated from the skin secretion of Hylarna guentheri. It is the first time to identify the biosynthetic precursor encoding cDNA of QUB-1439 from the skin secretion-derived cDNA library though the mature peptide sequence, FLPLLFGAISHLL-NH2, has been identified …
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A bioactive peptide QUB-1370 from the frog skin secretion of Pelophylax nigromaculata
… diseases. Bioactive peptides from amphibian skin secretions have been demonstrated to have multiple biological activities, such as antimicrobial activity, anticancer activity and so on. Furthermore, some of the peptides have been proven as the promising candidates of new drugs.<br/>A cDNA …
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QUB-1957: a bioactive peptide from the frog skin secretion of Hylarana latouchii
The skin secretions of amphibians are significant for amphibians’ daily protection, especially the antimicrobial peptides. In this study, a cDNA library from lyophilised skin secretion of Hylarana latouchii was constructed, and molecular cloning of biosynthetic precursor-encoding cDNAs of QUB-1957 …
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QUB-2454: a bioactive peptide from the frog skin secretion of Phyllomedusa palliate
… peptide precursor was discovered here in the skin secretion of Phyllomedusa palliate, and the mature peptide was subsequently named QUB-2454. The chemically-synthesised and purified QUB-2454 showed that QUB-2454 has potent antimicrobial activity against S. aureus and E. coli with MICs at 8μM, …
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QUB-1904: A Bioactive Peptide from the Frog Skin Secretion of Pelophylax esculentus
… BBIs have led to a renewed interest in amphibian skin-derived BBIs which have a much shorter chain and remarkable inhibitory effect. <br/><br/>In this study, a bioactive peptide, QUB-1904, was discovered from skin secretion of Pelophylax esculentus by shotgun cloning of a novel biosynthetic …
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QUB-3005, a bioactive peptide from the defensive skin secretion of Rana amurensis
… biologically active compounds exist in amphibian skin secretions, such as biogenic amines, steroids, complex alkaloids, and peptides. In the latter class of molecules, a large number of peptide antibiotics has been isolated and characterised from different amphibian species. Particularly, …
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