Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"skin microbiome"”.
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The skin microbiome in health and atopic dermatitis
The skin, as the body’s outermost layer of cells, plays a crucial dual role in protecting against foreign pathogens while providing a habitat for commensal microbes. Despite the skin’s harsh conditions, which include desiccation, acidity, and scarce nutrients, the skin hosts a diverse community of …
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Does the human skin microbiome adapt to antibiotic exposure?
… is a substantial element of the healthy human skin microflora and can become pathogenic to cause infections, for example, septicaemia and endocarditis. The effects of long-term sub-lethal exposure to antibiotics on the skin microbiota are unknown. How does antibiotic adaptation affect the …
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Lineage-level within-species dynamics in the human facial skin microbiome
… assembly dynamics in the human facial skin microbiome. In Chapter 2, I use new methods to improve lineage-level clustering and delineate 4,055 genomes of C. acnes and S. epidermidis isolates from human facial skin into 167 lineages. In Chapter 3, I use these data to observe natural …
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Assessing Diversity, Culturability and Context-dependent Function of the Amphibian Skin Microbiome
… those associated with chytridiomycosis, a lethal skin disease caused by the fungus Batrachochytrium dendrobatidis (Bd). Amphibian skin can harbor diverse bacterial communities that, in some cases, can inhibit the growth of Bd. Thus, there is interest in using skin bacteria as probiotics to …
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Investigating how bat ectoparasites influence the skin microbiome diversity and composition in Washington State bats
… relationship between bat ectoparasites and the skin microbiome in relation to WNS infection risk in Washington State bats. We hypothesized that bats with ectoparasites would have a decreased skin microbiome diversity thus increasing their susceptibility to Pd infection. We collaborated with …
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The role of the skin microbiome in amphibian pathogen susceptibility in Turnbull National Wildlife Refuge
… amphibian populations, but some bacteria in the skin microbiome can inhibit its growth. In Turnbull National Wildlife Refuge (TNWR) in eastern Washington, Bd is highly prevalent, but the role of the skin microbiome in Bd infection dynamics have not been examined in this region. We hypothesized …
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Impact of Chytrid fungus pathogen on the skin microbiome of frogs in northern Idaho and Turnbull National Wildlife Refuge, Washington
… to a disease. Researching the amphibian skin microbiome may provide solutions to conservation of amphibians. Two main relationships have been observed between Bd and the microbiome: 1) bacteria producing antifungal metabolites can inhibit Bd and improve survival against the disease and 2) …
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Staphylococci of the Skin: Consequences for Host Health
The skin is the body’s largest barrier organ, and as such hosts roughly one million bacteria per square centimeter over its 1.8m2 surface area. As a barrier organ, the skin not only provides a physical layer of defense against these microbes but an immunological one as well. Immune cells present in …
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Altered Vulvar Microbiomes in Vulvar Lichen Sclerosus
… given associations with autoimmune disease. The skin microbiome plays an important role in cutaneous immune function and may contribute to VLS pathogenesis or expression. OBJECTIVE: In this prospective, longitudinal study, we investigated the association between bacterial and fungal microbiomes …
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Bacteriophages in the honey bee gut and amphibian skin microbiomes: investigating the interactions between phages and their bacterial hosts
… (phages), may also shape the animal microbiome. Most phage lifecycles can be classified as either lytic or temperate. Lytic phages infect and directly kill bacterial hosts and can directly regulate bacterial population size. Temperate phages, in contrast, have the potential to undergo …
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Determinants of systemic treatment response in atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intense pruritus and recurrent eczema. Its heterogeneous pathophysiology involves epidermal barrier dysfunction, immune dysregulation, and alterations of the skin microbiome. Despite major advances through targeted …
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Tetrodotoxin, fungal pathogen infection, and bacterial microbiome associations are variable in the skin microecosystems of two Taricha Newt species
… intrinsic factors including host-associated skin microbes aiding defense through resource competition and antifungal metabolite production. Amphibians can also release toxins in response to stress cues to defend against disease, parasitism, and predation. Tetrodotoxin (TTX) is a potent low …
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The effects of salinity on the cutaneous microbiome and pathogen infection on the Pacific Tree frog (Pseudacris regilla) in Monterey Bay, California, USA
… Bd prevalence and intensity and the cutaneous microbiome of the common Pacific Tree Frog (Pseudacris regilla) across a salinity gradient (0.05-30 ppt) at 10 sites within the reserve. I hypothesized that amphibians in higher saline environments would have lower Bd infection rates and different …
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Mapping the microbiota in hidradenitis suppurativa
… suppurativa (HS) is a chronic inflammatory skin disease characterized by the formation of nodules, abscesses, and fistula at intertriginous sites. Pain, pruritus, malodour, and suppuration have a significant impact on quality of life for HS patients. The skin-gut axis is an area of emerging …
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Health, lifestyle and nature disconnect in high-rise apartment dwellers
… in maintaining immunological health. Human skin is continually exposed both to the environment and to cleaning and hygiene tasks that contribute to skin microbial composition. The study sought to answer a vital question: How do floor level and the lack of plants and soil in high rise …
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Studium vlivu kosmetických přípravků na mikrobiom lidské kůže pomocí molekulárních technik
Teoretická část práce se zabývá základním popisem fyziologie kůže, lidského mikrobiomu a stručného přehledu míst, kde se jednotlivé mikroorganismy vyskytují. Dále je uveden přehled použitých analytických a mikrobiologických metod, použitých v diplomové práci. Praktická část se v úvodu zabývá …