Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"skin inflammation"”.
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Fructose 1,6-diphosphate ameliorates UV-induced skin inflammation
"Fructose 1,6-diphosphate (FDP)는 해당과정 (glycolysis)상의 고에너지 대사 중간체로서 당대사와 관련된 여러 효소들의 allosteric regulator로서 작용할 뿐만 아니라 심혈관계 보호작용 등의 다양한 생리활성을 지니고 있는 것으로 알려져 있다. 피부세포에서는 최근 human keratinocyte cell line (HaCaT)에서 FDP가 UVB 유도 세포내 H2O2 및 prostaglandin 생성을 유의적으로 억제한다고 보고된 바 있다. 본 연구에서는 FDP가 자외선에 의해 유도되는 …
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Intravital Imaging of Dynamic Behaviors of Leukocytes in UVB-induced Skin Inflammation
… Langerhans cells (LCs) in the epidermis of the skin. Other leukocytes, such as neutrophils and macrophages, are recruited to the irradiated sites due to chemo-attracting factors released from the altered microenvironment. However, there is little evidence directly demonstrating the behavior of …
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Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
… (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3% in adults, worldwide. In the past three decades, prevalence of the disease has increased by two to three-fold in industrialized countries, with higher incidences in urban regions …
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Design, Product Development and Risk Assessment of Tin (sn) ring electrodes as a substitute to Silver-Silver Chloride (AG AgCI) ring electrodes for High Definition transcranial Direct Current Stimulation (HD-tDCS)
… is tin oxide/tin dioxide (SnO/SnO2). Afterwards, skin tolerability and subject sensation, along with the electrode potential, were assessed by stimulating forearms of seven subjects. A direct current of 1mA was administered for 20 minutes with application at the same location for five consecutive …
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Hypoxic Influences On Myeloid Cells During Inflammation And Inflammation-Associated Cancer
… not only to O2 deprivation at the site of inflammation, but also alter many of their functions in response to hypoxia to either facilitate or suppress inflammation. Hypoxia stabilizes HIF-αs in macrophages and neutrophils, and these O2-sensitive transcription factors are key regulators of …
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cDNA microarray Analysis Identifies Symptom-Associated Chemokine Genes in Behcet's Disease Mouse Model
… disease, is characterized by intraocular inflammation, oral ulcers, genital ulcers, skin lesions and additional accompanying changes. A developing aspect of BD is reached until eye symptoms are present from early mucocutaneous symptoms via arthritic and neurological symptoms, or systemic …
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Psoriasis activation of cells important in cardiovascular disease
… is a recognised characteristic of psoriatic skin inflammation. IL-36 induces inflammatory responses in dendritic cells, fibroblasts and epithelial cells. While vascular alterations are a hallmark of psoriatic lesions and dermal endothelial cells are well known to play a critical role in …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… is a serine protease and a pivotal regulator of skin desquamation, the physiological process of skin renewal (Brattsand et al., 2005; Borgoño et al., 2007). KLK5 is activated autocatalytically (Michael et al., 2005) and then, it activates other downstream proteases that are expressed in the …
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Molecular Mechanisms of Itch Sensations
… which causes scratching response to protect skin against external harmful reagents. Acute itch arises in short time period after insect bites or allergen contact. Chronic itch happens in various skin diseases such as atopic dermatitis: AD) and psoriasis. Chronic itch usually continues for …
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Epicutaneous Delivery of Allergens Using Dual Stimuli-Responsive Liposomes-Loaded Dissolving Microneedles
… across the stratum corneum (SC) without inducing skin inflammation or irritation. To enhance the efficacy of macromolecular allergen delivery through the SC, allergen-loaded liposomes incorporated into dissolving microneedles (dMN) were developed. The compatibility of food allergens with …
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Immune Regulatory Role of Human CD141+ Dendritic Cells in Humanised Models of Alloimmunity
… investigates the immune regulatory role of human skin DC subsets both in vitro and in vivo. A better understanding of human skin immune homeostasis and its regulation by specialized subsets of tissue residing immune sentinels is required. Here, we identify an immunoregulatory tissue resident DC in …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… people and is characterized by chronic airway inflammation, reversible airflow limitation, and airway hyperreactivity. AD is affecting approximately 15%-20% of the pediatric population and 7%-10% of adults in the world and is characterized by dysregulation of skin barrier and immunity, …
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An examination of the bioactive lipids involved in skin cell inflammation and in response to ultraviolet radiation. Effect of n-3 polyunsaturated fatty acid supplementation on red blood cell and human dermal fatty acid and production of eicosanoids by HaCaT keratinocytes and 46BR.1N fibroblasts following exposure to UVR.
… radiation (UVR) in solar light is important for skin biology. It is involved in the development acute and chronic skin inflammation, aging and cancer, causing erythema, tanning and local or systemic immunosuppression. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are considered anti- …
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Mapping the microbiota in hidradenitis suppurativa
… suppurativa (HS) is a chronic inflammatory skin disease characterized by the formation of nodules, abscesses, and fistula at intertriginous sites. Pain, pruritus, malodour, and suppuration have a significant impact on quality of life for HS patients. The skin-gut axis is an area of emerging …
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New lipid nanovesicles as topical delivery sistems for ant-inflammatory drugs
… delivery experiments showed an improved skin deposition of diclofenac when PEVs were used. Vesicle toxicity and uptake of fibroblasts, target of inflammation treatment, were evaluated by MTT test and fluorescence microscopy. Control liposomes and PEVs were both able to interact and being …
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New Mediators and Novel Mechanisms in Allergic Airway Inflammation
Hyperresponsiveness and inflammation are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. The aims of this thesis were to investigate if cytokines involved in the allergic response can induce airway hyperreactivity by …
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Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs
… Franz diffusion vertical cells and newborn pig skin, in comparison with diclofenac acid coarse suspensions and a commercial topical formulation containing diclofenac sodium. Nanocrystals exhibited a mean diameter ranging between 279 and 315 nm and a PI lower than 0.25, as shown by PCS …
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CHEMICAL APPROACHES TOWARD NEW PERSPECTIVES IN DRUG DISCOVERY: NATURAL PRODUCTS AND BIOACTIVE HITS AS AN INSPIRATION
… five among them as effective inhibitors of skin inflammation mediators; notably, the length of their side chain was critical for activity. This work highlights the potential of Cannabis components in addressing inflammatory skin conditions. Chapter 4 focuses on the efforts towards the total …