Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"skin disorder"”.
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An exploration of men's subjective experience of Vitiligo : a qualitative study
Vitiligo is a chronic skin disorder, which de-pigments parts or all of the skin. This disfiguring condition presents individual sufferers with many challenges. Studies have shown an adverse psychological impact of living with such a skin condition. However, no studies to date have explored the …
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Production and characterization of a phage endolysin with putative antimicrobial activity against Cutibacterium acnes
<p>Acne vulgaris (acne) is the eighth most common skin disorder worldwide. Because of the heterogeneous pathology of acne and the increasing antibiotic resistance of the causal agent (Cutibacterium acnes), novel therapeutics need to be developed to treat acne. One option is endolysins, highly …
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Characterisation of Rare Genetic Variants Conferring Susceptibility to Psoriasis
Psoriasis is an immune-mediated skin disorder that is inherited as a complex trait. Although genome-wide association studies (GWAS) have identified a number of common disease susceptibility alleles, a substantial fraction of psoriasis heritability remains unexplained, suggesting the possibility …
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A molecular genetic analysis of Crohn’s disease susceptibility loci in psoriasis
Psoriasis is an immune-mediated skin disorder that is inherited as a complex trait. Genome-wide linkage and association studies have identified a major disease susceptibility locus (PSORS1) and several genetic determinants of smaller effect. At least two of these (the IL12B and IL23R genes) have …
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Exploring and Changing Cognitive Representations, Coping and Quality Of Life Outcomes in Chronic Spontaneous Urticaria
Chronic Spontaneous Urticaria (CU) is a pruritic skin disorder that affects 0.8% of the population. As its aetiology is not fully understood the aim is to control symptoms through medicines to improve quality of life (QoL). Demographic and clinical factors have been inconsistent and poorly predict …
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Skin Deep: Genetic Characterization And Prediction Of Russet Formation In ‘Honeycrisp’-Derived Apple Breeding Germplasm
… apples (Malus domestica Borkh.) is a superficial skin disorder that detracts from fruit appearance and is a breeding target in many apple scion breeding programs. To-date, the understanding of the genetic basis of russet in apple has been limited to a relatively narrow set of germplasm. …
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Maternal Serum and Whey Immune Markers and Eczema Among Infants
… considered to either de- or increase risk of the skin disorder. We conducted a prospective study to contrast the role of different maternal immune markers (MIMs) in maternal serum and whey on the development of eczema symptoms in infancy. Pregnant women were recruited in Columbia and Charleston, …
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Melanocyte survival and response to treatment in Vitiligo Patients
Vitiligo is a common depigmenting skin disorder with devastating psychological implications. Although evidence strongly suggests that melanocytes die in various forms of vitiligo, it is also evident, at least in certain cases, that melanocytes/melanoblasts survive in an undifferentiated stem cell …
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Molecular mechanisms controlling the expression of the HLA-Cw*06 psoriasis susceptibility allele
Psoriasis is an inflammatory skin disorder that is inherited as a common and complex trait. Linkage studies have repeatedly identified a primary disease susceptibility locus (PSORS1) spanning 250 kb within the Major Histocompatibility Complex. Deep sequencing experiments and genome-wide association …
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DRUMBEAT© for arthritis “ a shared purpose” rather than a “lonely struggle”
… among others. Classified as chronic autoimmune disorders, the symptoms of inflammatory arthritis (IA) are not localised to the damaged joint, and individuals may also experience fever, weakness, and organ damage, in addition to the stiffness and pain in the joints. As the sample size of this …
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Patients presenting to primary and secondary care with dermatological conditions in south-east Scotland with reference to the dermatological training of general practitioners
… of approximately 104,621 were asked to note all skin -related consultations during a two -week period. The case notes of these patients were reviewed, and diagnosis and treatment was recorded. Patients who had consulted for the same skin disorder on >/ =3 occasions during the previous year were …
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Redefinition of uraemic cardiomyopathy with cardiac magnetic resonance imaging
… fibrosis (NSF), a potentially life threatening skin disorder in patients with advanced renal failure. This finding lead to the cessation of contrast CMR studies. A retrospective investigation of factors present in patients in North Glasgow affected by NSF, confirmed that patients with NSF were …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… is a serine protease and a pivotal regulator of skin desquamation, the physiological process of skin renewal (Brattsand et al., 2005; Borgoño et al., 2007). KLK5 is activated autocatalytically (Michael et al., 2005) and then, it activates other downstream proteases that are expressed in the …