Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"skin carcinogenesis"”.
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Heat stress: A risk factor for skin carcinogenesis
BACKGROUND: The incidence of skin cancer in Australia has increased rapidly in the last few decades. Ultraviolet radiation (UV) is a major risk factor for skin carcinogenesis. UV, particularly the UVB spectrum, causes formation of cyclobutane pyrimidine dimers (CPD) in cellular DNA. Persistent and …
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The Role of Erbb2 in Ultraviolet-Induced Nonmelanoma Skin Carcinogenesis
… introduction - no abstract provided) Nonmelanoma skin cancer is more common than all other forms of cancer combined and its incidence is increasing. Most of these cancers are caused by UV, which has many effects on the skin. The RTK Erbb2 is activated by UV and is overexpressed in some skin …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… protein (BMP) signalling plays key roles in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of the BMP …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
… protein (BMP) signalling plays key roles in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of the BMP …
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The Effects of Radon and its Progeny on Human Skin Cells
… lung cancer, therefore its potential role in skin carcinogenesis is of interest, as Southwest England also has high skin cancer incidence. A novel radium-226 flow-through apparatus was employed to dissolve radon and its progeny into cell media. Cultured human skin fibroblasts (84BR), squamous …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… to explore the role of Stat1 during multistage skin carcinogenesis. Topical treatment with both TPA and the anthrone derivative chrysarobin (CHRY) led to rapid phosphorylation of Stat1 on both tyrosine (Tyr701) and serine (Ser727) residues in epidermis. CHRY treatment also led to upregulation of …
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Migration Stimulating Factor, the search for inhibitors.
… were assessed using an in vitro model for human skin carcinogenesis, the HaCaT –ras clones. The shift in tumorigenic potential from benign to metastatic was characterised by a decrease in NGAL and an increase in MSF expression, indicating their potential role in tumour progression.<br/>The …
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Understanding Nanog'S Role In Cancer Biology
… inhibited tumor formation in a two-stage skin carcinogenesis model. We also noted a depletion of skin stem cell populations, which underlies the wound-healing defect our mice harbor as well. Gene expression analysis shows a reduction in c-Jun and Bmp5, two genes whose loss inhibits skin …
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Targeting Akt/Mtor Signaling Pathways During Murine Skin Tumor Promotion and The Impact of Dietary Energy Balance Manipulation
… (CR) has been shown to be a potent inhibitor of carcinogenesis across a broad range of species and tumor types. Previous data has demonstrated differential signaling through Akt and mTOR via the IGF-1R and other growth factor receptors across the diet-induced obesity (DIO)/CR spectrum. …
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Regulation and Targeting of Fyn in Human Cutaneous Squamous Cell Carcinoma
… total tumor burden in the SKH1 mouse model of skin carcinogenesis (p<0.05). Together these results identify the promotion of actin-based cell-cell adhesion as a newly described mechanism of action for Dasatinib and suggest that Fyn inhibition may be an effective therapeutic approach in treating …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
… signaling plays a critical role in mammalian skin. Removal of Notch alleles in skin keratinocytes has been associated with an array of phenotypes with varying severity based on the identity and number of remaining Notch receptors. Phenotypes include carcinogenesis: in the case of Notch1 loss), …
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The Regulation of Oncogenic MAP Kinase Signalling by Dual-Specificity MAP Kinase Phosphatases
… function in the murine model of DMBA/TPA-induced skin carcinogenesis. We also show that the endogenous expression of mutant KRasG12D in murine fibroblasts induces the expression of both DUSP5 and DUSP6/MKP-3, suggesting these proteins are involved in the negative feedback response, which …
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Investigating The Roles of Tap63 and Tap73 In Cutaneous Squamous Cell Carcinoma and Lung Adenocarcinoma
… essential regulator of miRNA expression during skin carcinogenesis and reveals a previously undescribed network of miRNAs and mRNAs, which include viable, yet previously unexplored targets for therapeutic intervention. Along with TAp63-mediated tumor suppression in the skin, I have also …
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Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
… as with a MMTV-Cre mouse line. I have conducted carcinogenesis studies with these mice. The K5-Cre crossed mice have been subjected to skin carcinogenesis study using the DMBA/TPA system and to a p53+/- genetic cross. The MMTV-cre crossed mice have been subjected to ageing studies. I have also …
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Role of Stat3 In Keratinocyte Stem Cells During Skin Tumorigenesis
… KSCs. To further understand the role of KSCs in skin tumorigenesis, K5.Stat3C transgenic (Tg) mice which express a constitutively active/dimerized form of Stat3 called Stat3C via the bovine keratin 5 (K5) promoter were studied. The number of CD34 and α6 integrin positive cells was significantly …
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Generation and characterization of novel mouse models to validate the role of KLK5 protease in inflammation for pharmacological applications
… is a serine protease and a pivotal regulator of skin desquamation, the physiological process of skin renewal (Brattsand et al., 2005; Borgoño et al., 2007). KLK5 is activated autocatalytically (Michael et al., 2005) and then, it activates other downstream proteases that are expressed in the …