Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"skeletal myogenesis"”.
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ROLE OF G9A IN SKELETAL MYOGENESIS
… that mutations in sarcomeric proteins underlie skeletal muscle disease and dysfunction. Here, we provide evidence that the lysine methyltransferase G9a represses expression of several sarcomeric genes, whereby over-expression of G9a disrupts sarcomere integrity of skeletal muscle cells. This …
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Functional Genomics Characterization of Six4 During Skeletal Myogenesis
Adult skeletal muscles can regenerate after injury due to the presence of satellite cells, a quiescent population of myogenic progenitor cells characterized by expressing the transcription factor Pax7. Once activated, satellite cells repair the muscle damage and replenish the stem cell niche due to …
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Muscle-derived cytokines: novel regulators of skeletal myogenesis
Mature skeletal muscle has a uniquely robust capacity for regeneration. This ability is due in large part to the resident population of muscle stem cells in the tissue, known as satellite cells. These adult stem cells reside in a quiescent state near the basal lamina of skeletal myofibers, but are …
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Regulation of skeletal myogenesis by the mTOR signaling network
Skeletal muscle is composed of post-mitotic multinucleated myofibers. During embryonic skeletal myogenesis, cells in somites commit to myogenic lineage and differentiate into myoblasts, which then fuse to form multinucleated myofibers. Post-natal growth, repair, and maintenance of skeletal muscle …
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Regulation Of Cyclic-amp-dependent Protein Kinases During Skeletal Myogenesis
L6 myoblasts are a permanent rat skeletal myoblast cell line which differentiates in culture to form multinucleate myotubes. The regulation of the levels of cAMP-dependent protein kinases during myogenesis in L6 was studied, as these enzymes have been proposed to be involved in the control of this …
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Investigating the molecular function of Akirin during skeletal myogenesis in Drosophila melanogaster
… new intermolecular partners for Akirin during myogenesis, we have shed new light on the molecular action of Akirin during embryonic development.</p>
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Non-canonical functions of leucyl-tRNA synthetase: Mechanism of cell growth and skeletal myogenesis
… in cell growth, myogenic differentiation, and skeletal muscle regeneration. Amino acid availability activates signaling by mTORC1. The class III PI-3-kinase Vps34 mediates amino acid signaling to mTORC1 by regulating lysosomal translocation and activation of the phospholipase PLD1. In …
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H36-alpha7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis
… that is expressed during the differentiation of skeletal muscle. H36 cDNA clones were isolated from a lambda UniZapXR rat myotube cDNA library and sequenced. The deduced amino acid sequence demonstrates that H36 is a novel integrin alpha chain that shares extensive homology with other alpha …
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Regulation of Skeletal Muscle Differentiation by a Rapamycin -Sensitive Signaling Pathway
… proteins critical in mTOR signaling during skeletal myogenesis.
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mTOR Signaling in Cellular Growth and Skeletal Muscle Maturation
… S6K1 homologue, S6K2, and for the regulation of skeletal muscle myotube growth. My results showed that S6K2 requires mTOR and its kinase activity for its activation. Amino acid and nuclear-cytoplasmic shuttling of mTOR were shown to be required for S6K2 activation. Skeletal myogenesis is a …
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Membrane-cytoskeleton associations during myogenesis
… inhibited or promoted the fusion of L8E63 rat skeletal muscle cells in culture, and this suggests that the fusion of skeletal myoblasts is regulated by distinct, cell surface components. Such perturbations of myoblast fusion by antibodies may reflect interactions between the cell surface and …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… state to the fully differentiated skeletal myocyte is orchestrated by a highly complex network of transcription factors whose expression is regulated by several families of molecules. However, not much is known about the early events that lead to the expression of muscle progenitor …
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Molecular mechanisms of mammalian cell survival and differentiation
… (miR-146b) as a novel positive regulator of skeletal myogenesis. Inhibition of miR-146b led to reduced myoblast differentiation, whereas overexpression of miR-146b enhanced differentiation. In addition, miR-146b directly targets Smad4, Hmga2, and Notch1 in muscle cells. The expression of …