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Showing 1 to 20 of 35 for “"skeletal muscle tissue"”.
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Enhancing the functionality and applicability of engineered skeletal muscle tissue
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Role of MicroRNAs in Human Skeletal Muscle Tissue Engineering In Vitro
<p>The development of a functional tissue-engineered human skeletal muscle model in vitro would provide an excellent platform on which to study the process of myogenesis, various musculoskeletal disease states, and drugs and therapies for muscle toxicity. We developed a protocol to culture human …
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Methodologies to promote muscle development for engineering functional skeletal muscle tissue
The student, Eunkyung Ko, accepted the attached license on 2019-04-11 at 16:50.
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Creation and Characterization of Several Polymer/Conductive Element Composite Scaffolds for Skeletal Muscle Tissue Engineering
After skeletal muscle damage, satellite cells move towards the injured area to assist in regeneration. However, these cells are rare as their numbers depend on the age and composition of the injured muscle. This regeneration method often results in scar tissue formation along with loss of function. …
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Proteomic profiling of skeletal muscle tissue from the Goto-Kakizaki rat model of type 2 diabetes.
… peripheral insulin resistance characterise T2D. Skeletal muscle is the largest insulin-regulated glucose sink in the body and represents approximately 80% of whole body insulin-stimulated glucose uptake. As a result a fundamental aspect of T2D is abnormal glucose disposal in contractile tissues …
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Bioartificial scaffolds with biomimetic fibrous structure in the design of in vitro models of cardiac fibrotic and skeletal muscle tissue
L'abstract è presente nell'allegato / the abstract is in the attachment
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The Distribution of opiates, cocaine and their metabolites in skeletal muscle tissue and vitreous humour as an aid to post-mortem toxicological interpretation.
… reflect the concentration at the time of death. Tissues that are located away from central drug reservoirs and that lack esterase activity, e.g. muscle and vitreous humour (VH), have the potential to provide more reliable post-mortem toxicological specimens. In the absence of a blood sample the …
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The metabolic profile of cardiac and skeletal muscle tissue from captive emus (Dromaius novaehollandiae) raised in northern Colorado: implications for assessing muscle health for emus with splayed-leg disorder
… studies have been performed on domesticated emu skeletal muscle, and there have been no investigations into the enzymatic profile of domesticated ratite (group of paleognathous flightless birds that includes emus) cardiac tissue. This thesis established the first ratite cardiac metabolic profile …
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Regulation of Protein Turnover during Hyper-osmotic Stress in Skeletal Muscle
… of hyper-osmotic stress on protein turnover in skeletal muscle tissue using an established in-vitro model. Rat EDL muscles were incubated in either hyper-osmotic (400 ± 10 Osm) or isoosmotic (290 ± 10 Osm) custom-modified media (Gibco). L-[14C]-U-phenylalanine (n=8) and cycloheximide (n=8) were …
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Cryopreservation of tissue engineered skeletal muscle
Tissue engineered skeletal muscle plays an important role not only in the field of regenerative medicine, but also in emerging areas such as soft robotics, organ-on-a-chip models of disease, and drug testing. However, further expansion of the applications of tissue engineered skeletal muscle models …
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Developing a Functional in Vitro Model of the Neuromuscular Interface
… junction (NMJ), which is the connection between skeletal muscle and motor neurons and is relevant in many neuromuscular degenerative diseases. This work identifies that current in vitro NMJ models are cohesively lacking the ability to support long-term, functionally contractile muscle tissue …
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Controlled Myogenic Differentiation of Mammalian Cell Lines by Temperature-Inducible Systems
Efficient in vitro generation of skeletal muscle tissue from cell lines is pivotal for the advancement of cultivated meat production. Here, we introduce a novel system employing a synthetic temperature-sensitive promoter (HSP70) carrying multiple heat shock elements (HSE), whose activity can be …
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Decellularized Apium graveolens Scaffold for Cell Culture and Guided Alignment of C2C12 Murine Myoblast
The development of in vitro meat from validated tissue engineering techniques has emerged as a more sustainable and ethical method of meat production. To date, the expansion of cellular agriculture is believed to be dependent on four pillars: animal free scaffolds, serum free media, bioreactors and …
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Biofunctional hydrogels for skeletal muscle constructs
Skeletal muscle tissue damage costs the US government hundreds of billions of dollars annually. Meanwhile, there is great potential to use skeletal muscle as a scalable actuator system, covering wide length scales, frequencies, and force regimes. Hence, the interest in soft robotics and …
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Enhancing functionalities of engineered skeletal muscle tissues by recreating natural environmental cues
Engineered skeletal muscle tissue is a three-dimensional contractile tissue made from muscle cells and the extracellular matrix (ECM). It can be used as a drug testing platform or an implantable tissue, but its practical use has been limited by inferior contractile performance and small size …
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Human obesity and its influence on muscle protein synthesis
Improving skeletal muscle health is an important component of obesity treatment. Apart from locomotion, skeletal muscle tissue is fundamental for the regulation of macronutrient metabolism during the postprandial period, which is precisely where metabolic derangements are most often observed. In …
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SUFU in SHH signalling mediated myogenesis
Myogenesis is defined as the formation of skeletal muscle tissue during embryonic development and involves a multitude of cellular signalling pathways. Among these include the Sonic hedgehog (Shh) signalling pathway which must be deactivated for differentiation into muscle cells to occur. However, …
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A Composite Material-based Computational Model for Diaphragm Muscle Biomechanical Simulation
… predicts the deformation field of the diaphragm muscle during respiration. The first part of the project involved developing an accurate and adaptable micro-to-macro mechanical approach for skeletal muscle tissue modelling for application in a FE solver. The next objective was to develop the …
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Regulation of LKB1-STRAD-MO25 Complex Expression and Activation of AMPK in Skeletal Muscle by Thyroid Hormone
… which serves as a metabolic master switch in skeletal muscle, is a research target for the pharmaceutical treatment and prevention of type 2 diabetes. The expression of all of the isoforms of the subunits of AMPK and AMPK activity are increased in skeletal muscle tissue of hyperthyroid rats. …
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Understanding adaptive regulation of skeletal muscle physiology in the Weddell seal: a proteomics approach
… adults. Proteins from the primary swimming muscle (M. longissimus dorsi) of two distinct age classes, pups (3-5 weeks/nondivers) and adults (7+ years/expert divers), were visualized using two dimensional gel electrophoresis (2DE), quantified, and identified. This study validated the use of …
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