Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"skeletal muscle metabolism"”.
-
Signaling pathways regulating skeletal muscle metabolism and growth
Skeletal muscle can perceive cellular energy status and substrate availability and demonstrates remarkable plasticity in response to environmental changes. Nonetheless, how skeletal muscle and its resident stem cells (satellite cells; SCs) sense and respond to nutrient flux remains largely …
-
Myogenin Modulates Exercise Endurance By Altering Skeletal Muscle Metabolism
… of these MRFs, myogenin (Myog), during embryonic muscle development suggests an equally important role in adult muscle. In this study, we have determined the function of myogenin during adult life using a conditional allele of Myog. In contrast to embryonic development, myogenin is not required …
-
The Role of Angiotensin II in Skeletal Muscle Metabolism
… recently been investigated for its effects on metabolism and diabetes. Since skeletal muscle is one of the most metabolically active tissues, this study investigates the effects of angiotensin II specifically on skeletal muscle. In this study, L6 skeletal muscle cells were treated with …
-
Whole-Body Metabolic Flexibility is Discordant with Skeletal Muscle Metabolism
… in response to substrate availability. Skeletal muscle (SkM) is a regulator of metabolic flexibility as it is the primary tissue responsible for post-prandial substrate handling, and metabolic inflexibility can be seen in the SkM of individuals with metabolic disease. As Western style …
-
Elucidating Functional Roles For Myogenin In Adult Skeletal Muscle Metabolism, Exercise Capacity, and Regeneration
… Myf5, MRF4, and MyoD are critical for embryonic skeletal muscle development. Myogenin is necessary for the terminal differentiation of myoblasts into myofibers during embryogenesis, but little is known about the roles played by myogenin in adult skeletal muscle function and metabolism. …
-
The role of Toll-like Receptor 4 in the Modulation in Skeletal Muscle Metabolism
… demonstrated that activation of TLR4 in skeletal muscle results in the preferential oxidation of glucose for ATP production over that of fatty acids. Currently, the exact mechanism(s) for TLR4-induced modulation of metabolism are not known. The purpose of this project was to test the …
-
The Role of High Saturated Fatty Acid Diets on Skeletal Muscle Metabolism and Inflammation
… determine if the metabolic adaptive response in skeletal muscle to a single, high fat meal was altered by 5 days of high saturated fat feeding. Twelve college-age, non-obese males were studied and skeletal muscle samples were obtained prior to and concluding the consumption of a high SFA diet. In …
-
Acute and chronic heat stress alters the metabolic profile of skeletal muscle in growing swine
… lean tissue accretion. Perturbations in skeletal muscle metabolism may participate in this defect. The study objectives were to examine the cellular bioenergetic profile in skeletal muscle of piglets subjected to thermal stress in utero and/or during postnatal life. To accomplish this, 96 …
-
Energy metabolism in skeletal muscle: mechanistic insights into mitochondrial function and growth
Skeletal muscle metabolism is critical to understanding the efficiency of muscle growth for the global meat industry. As such, there are many contributing factors that can influence muscle growth yet there are still basic molecular mechanisms that remain unexplored. Specifically, the involvement of …
-
Skeletal muscle structure and metabolism in chronic heart failure
… to the exercise intolerance. Maladaptations in skeletal muscle appear to be a likely reason for the limited exercise tolerance. In study I, exercise tolerance and skeletal muscle metabolism and morphology were examined in 17 CHF patients and eight healthy similarly aged sedentary control …
-
Modulation of exercise-induced gene expression in human skeletal muscle by exercise intensity, training status and short-term endurance training
… the modulation of gene expression in human skeletal muscle under varying physiological conditions, including divergent exercise intensities, untrained and trained muscle, and short-term endurance training. Compared to low intensity isocaloric exercise (400 kcal, 40%VO2peak), a single bout of …
-
Influence of biological sex and thyroid hormone on skeletal and cardiac muscle metabolism in heat-stressed pigs
… warming temperatures caused by climate change. Skeletal muscle, which is the main source of income for the meat industry, is particularly sensitive to HS. Lean tissue accretion declines during HS, in part because of inefficient metabolism and altered metabolic flexibility. The first study …
-
The role of Calcineurin in skeletal muscle differentiation
… that Calcineurin levels are higher in fast muscle fibers compared to slow-twitch in resting skeletal muscles. Activation of the Calcineurin in 4 skeletal muscle myocytes selectively up-regulates slowfiber- specific gene promoters through a mechanism involving the transcription factor NFATcI. …
-
Investigating the Role of Standing Blood Pressure Measurement and the Association Between High-Density Lipoprotein and Skeletal Muscle Mitochondrial Function in Pre-Hypertensive Humans
… between high-density lipoprotein (HDL) and skeletal muscle mitochondrial function. Herein, we are the first to observe that standing BP measurements are highly accurate in detecting HTN when compared to seated BP. These findings demonstrate standing BP as a novel tool to enhance the accuracy …
-
The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation
… on the cell surface of immune cells as well as skeletal muscle and other metabolic tissues. A compelling body of evidence shows that muscle TLR4 and the downstream cytokine signaling modulate skeletal muscle metabolism. Intriguingly, skeletal muscle has been demonstrated to gain favorable …
-
Novel drug and exercise therapies to restore metabolic function in children with severe burns
… workload, elevated energy expenditure, altered muscle metabolism, a severe loss in lean body mass, and impaired physical function. This stress response can extend well beyond wound healing, which can negatively impact an individual’s quality of life and their ability to reintegrate into society. …
-
Impacts of maternal dietary fat intake on fetal development in an ovine model
… dietary fats impact fetal development and metabolism has been limited by ethical and logistical challenges of such studies in humans, highlighting the need for affordable large animal models of human pregnancy for evaluating these interventions. The primary aim of this dissertation was to …
-
Skeletal Muscle Protein Metabolism and Molecular Responses to Endurance Exercise and Nutritional Interventions
It has been suggested that the gradual loss of muscle mass observed with healthy aging is the result of a resistance of aged muscle tissue to normally potent anabolic stimuli. Recent evidence indicates an age-related anabolic resistance in skeletal muscle tissue to exogenous amino acids and to a …
-
AMP-activated protein kinase and muscle metabolism
… protein kinase (AMPK) is a major regulator of skeletal muscle metabolism with relevance to agriculture and human health. During the conversion of muscle to meat, the rate and extent of postmortem metabolism and pH decline largely determine pork quality development. Pigs with the AMPKγ3 R200Q …
-
Skeletal Muscle Adaption to 5 days of High-Fat Feeding in Humans
Skeletal muscle is highly involved in macronutrient metabolism. To maintain proper energy metabolism and physiology, skeletal muscle must adapt to nutrient supply. Thus, diet macronutrient composition is an important modulator of skeletal muscle metabolism. Evidence from rodent and human models …
Page 1 of 2