Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 57 for “"skeletal muscle cells"”.
-
Roles of Zinc in Skeletal Muscle Cells Growth
Zinc deficiency impairs skeletal muscle growth in both humans and animals independently of decreased food intake. Insulin-like growth factor (IGF) is the primary regulator of postnatal muscle growth and there is substantial evidence that the effects of zinc deficiency alter IGF mediated muscle …
-
The effects of linoleate on insulin action in skeletal muscle cells
… linoleate-induced insulin resistance in L6 rat skeletal muscle cells, the inhibition of IRS-1-dependent signalling arises via effects on both the phosphorylation status and degradation of IRS-1, which are mediated, in part, by IKKb. In addition, the reduction of IRS-1 mRNA levels allude to …
-
Effects of naringenin on glucose uptake in L6 skeletal muscle cells
… in the classic target tissues (adipose, muscle, liver), as well as defects in a-cells and kidney, brain, and gastrointestinal tissue. Present oral treatments, which aim at mimicking the effects of insulin, remain limited in their efficacy and therefore the study of the effects of novel …
-
Microtubule Motors Drive Nuclear Dynamics and Positioning in Developing Skeletal Muscle Cells
… such as muscular dystrophy and myopathy. Skeletal muscle cells are large syncytia formed by fusion of myoblasts, and contain hundreds of nuclei positioned regularly along the length the cell. During muscle cell development, nuclear movement in myotubes requires microtubules, but the …
-
Investigating IL-15 Metabolic Impact and Its Mechanism of Action in Skeletal Muscle Cells
Skeletal muscle secretes many signalisation proteins named myokines. These myokines act as hormones and induce metabolic changes throughout the whole body to facilitate adaptation to physical exercise. Interleukin-15 (IL-15) is highly expressed in skeletal muscle and appears to influence many …
-
An in vitro investigation of the molecular effects of aging and exercise signaling within human skeletal muscle cells
… sarcopenia being of utmost concern in regard to skeletal muscle (SKM) health. Sarcopenia is associated with additional morbidities, including insulin resistance, resulting in the reduced quality of life in these individuals. Resistance exercise is a common form of treatment for sarcopenia to …
-
Nitrite and insulin lower the oxygen cost of ATP synthesis in skeletal muscle cells by pleiotropic stimulation of glycolysis
… nitrate) affects the bioenergetics of cultured skeletal muscle cells. Comparison between the acute effects of nitrite and insulin, a hormonal regulator of muscle function that increases mitochondrial efficiency, was explored to assess possible mechanistic overlap. Calculation of real-time …
-
Dynamics of membrane damage to skeletal muscle cells at supraphysiological temperatures and the role of poloxamer 188 in minimizing membrane injury
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1994.
-
Regulation of Glut-4 Expression in Skeletal Muscle cells: The Roles of Nuclear Respiratory Factor-1 and calcium/calmodulin dependent protein Kinase
GLUT4 protein is the major glucose transporter in skeletal muscle and is vital in the maintenance of euglycemia (17; 108). Underexpression of GLUT4 or impairement of its translocation from intracellular compartments to the cell surface, are linked to diminished glucose transport, hyperglycemia and …
-
Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… Models used for investigation included the L6 skeletal muscle cell line and isolated skeletal muscles. In vivo studies were undertaken to investigate glycaemia, insulinaemia, satiety and body weight in streptozotocin-induced diabetic mice and obese (ob/ob) mice. Leptin acutely altered insulin …
-
Cellular Reprogramming in Skeletal Muscle after Repeated Exposures to Endotoxin
… (T2DM), and cardiovascular disease (CVD). Immune cells exhibit a protective ability to develop endotoxin tolerance. The objective of this study was to determine if endotoxin tolerance exists in skeletal muscle cells, and if a condition that mimics a state of over nutrition, such as elevated levels …
-
Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
… decreases insulin resistance and inflammation in skeletal muscle via GCN2 pathways 1 Ⅰ. INTRODUCTION 2 Ⅱ. MATERIALS AND METHODS 8 A. MATERIALS 9 B. METHODS 10 1. Preparation of PA 10 2. Cell culture 10 3. Immunoblot analysis 11 4. RNA isolation and quantitative real-time polymerase chain reaction …
-
Oxygen Generating Materials for Tissue Restoration and Regeneration
Traumatic injury to skeletal muscle produces a physiological deficit resulting in deterioration of tissue structure and function. The restoration or regeneration (i.e., tissue engineering) technologies required to effectively treat these injuries would benefit from provision of oxygen in situations …
-
Biofunctional hydrogels for skeletal muscle constructs
Skeletal muscle tissue damage costs the US government hundreds of billions of dollars annually. Meanwhile, there is great potential to use skeletal muscle as a scalable actuator system, covering wide length scales, frequencies, and force regimes. Hence, the interest in soft robotics and …
-
Developmental regulation of the alpha(7) integrin chain during myogenesis
… integrin is the major laminin receptor on skeletal muscle cells. Its expression is developmental regulated during myogenesis. Not only is the expression of $\alpha$7 transcripts increased upon myogenic differentiation, differential splicing of transcripts is also observed at that time. This …
-
Modulation of Mitochondrial Respiration and Metabolic Signalling in Skeletal Muscle by Caveolin-3
… PhD were to determine the contribution that the muscle specific Cav3 isoform may make to mitochondrial respiratory capacity and to determine whether Cav3 has a role to play in the nutrient-dependent activation of mTORC1, an event that has been shown to be closely associated with the lysosome. …
-
ROLE OF G9A IN SKELETAL MYOGENESIS
… are the basic contractile unit of striated muscle and is essential for muscle contractile function such that mutations in sarcomeric proteins underlie skeletal muscle disease and dysfunction. Here, we provide evidence that the lysine methyltransferase G9a represses expression of several …
-
Gluconeogenic FBP1 plays a key metabolic role in activated T cells
… (F6P). It is active in liver, kidney and skeletal muscle cells. This study suggests that FBP1 plays a novel non-gluconeogenic role in T cells. Targeted metabolomics using [13C]-6-glucose revealed a labeling pattern of F6P in stimulated CD3+ T cells that could only have resulted from FBP1 …
-
Nutritional Supplementation and Skeletal Muscle Health in Chronic Diseases
… This thesis mainly focuses on obesity and aging. Skeletal muscle performance is impaired in obesity and aging conditions. One common reason causing this could be higher fat mass and lower muscle mass. However, there is no study showing what pathways are involved in the imbalance of body …
Page 1 of 3