Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 989 for “"skeletal muscle"”.
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Biofunctional hydrogels for skeletal muscle constructs
Skeletal muscle tissue damage costs the US government hundreds of billions of dollars annually. Meanwhile, there is great potential to use skeletal muscle as a scalable actuator system, covering wide length scales, frequencies, and force regimes. Hence, the interest in soft robotics and …
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Force response of locust skeletal muscle
… force response of the locust hind leg extensor muscle to input excitation pulses is modelled. Despite the processes behind muscle contraction being well established, no broadly valid method of modelling skeletal muscle exists. Studies that compare the merits of existing models are extremely …
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Cryopreservation of tissue engineered skeletal muscle
Tissue engineered skeletal muscle plays an important role not only in the field of regenerative medicine, but also in emerging areas such as soft robotics, organ-on-a-chip models of disease, and drug testing. However, further expansion of the applications of tissue engineered skeletal muscle models …
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The Satellite Cell of Skeletal Muscle
This thesis is centred on a unique feature of the skeletal muscle fibre, the satellite cell. This small fusiform cell, lying in a subsarcolemmal position, is the most recently discovered cytological entity of skeletal muscle. It can be readily distinguished from other better-known mononuclear cells …
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Postmortem metabolism in porcine skeletal muscle
Once an animal is harvested for meat, skeletal muscle attempts to maintain ATP at or near antemortem levels. To maintain ATP levels postmortem, stored glycogen is catabolized to produce ATP through glycolysis and possibly oxidative metabolism. Hydrolysis of the produced ATP acidifies muscle until …
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Does Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?
The skeletal muscle is a highly plastic tissue that is able to adapt to changes from different stressors such as exercise. Angiogenesis is the formation of new capillaries from existing vessels; allowing for better blood flow to the working skeletal muscles. Epigenetic modifications support changes …
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Regulation of Glycogenolysis in Anaerobic Skeletal Muscle
Functional compartmentation of anaerobic metabolism was demonstrated in intact tissue. Force-independent ATP utilization, primarily the Ca 2+ pump of the sarcoplasmic reticulum, preferentially uses ATP derived from glycogenolysis. ATP produced by creatine kinase is used mostly by force-dependent …
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Mechanical Properties of Maturing Dystrophic Skeletal Muscle
… of maturing dystrophic compared to control skeletal muscle membranes are weaker, leading to onset of Duchenne muscular dystrophy (DMD). We built on a previous report from our lab that suggested sarcolemmal membranes from dystrophic mice are not more susceptible to damage early in maturation …
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Muscle-specific considerations for aging human skeletal muscle
… some evidence that the age-associated change in skeletal muscle mass is muscle specific, yet the number of specific muscles that have been studied to form our understanding in this area is limited. In addition, few aging investigations have examined multiple muscles in the same individuals. This …
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Aging Skeletal Muscle Plasticity in Exercise and Injury
Sarcopenia—progressive loss of muscle mass and strength—diminishes quality of life and longevity. In addition to progressive atrophy, older adults exhibit impaired regeneration after muscular injury. Activity of muscle stem cells, termed satellite cells, is dysregulated with aging which impairs …
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Cellular and molecular regulation of skeletal muscle regeneration
<p>Skeletal muscle regeneration provides a powerful model to study the cellular and molecular mechanism governing stem cell function since the whole process is mediated by a population of muscle-resident stem cells called satellite cells. The overall aim of this dissertation is to explore the roles …
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Magnetic resonance elastography studies of human skeletal muscle
… and analysis protocols optimised to study thigh muscle mechanical properties. The protocols are subsequently applied in healthy volunteers to study natural phenomena such as contraction and ageing and interventions such as an experimental protocol to produce Exercise Induced Muscle Damage (EIMD). …
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Diet, inflammation and skeletal muscle mass in women
… Sarcopenia is the progressive decline of muscle mass, strength and function that occurs with healthy ageing. The ageing process is also associated with a gradual increasing production of pro-inflammatory cytokines, which may potentially enhance the development of sarcopenia. Dietary …
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The role of Calcineurin in skeletal muscle differentiation
… that Calcineurin levels are higher in fast muscle fibers compared to slow-twitch in resting skeletal muscles. Activation of the Calcineurin in 4 skeletal muscle myocytes selectively up-regulates slowfiber- specific gene promoters through a mechanism involving the transcription factor NFATcI. …
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Ischemia Impairs Vasodilation in Skeletal Muscle Resistance Artery
… the impact of chronic ischemia and age on skeletal muscle resistance artery function. To examine the impact of chronic ischemia, the femoral artery was resected from young (2-3mo) and adult (6-7mo) mice and the profunda femoris artery diameter was measured at rest and following gracilis …
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Roles of Zinc in Skeletal Muscle Cells Growth
Zinc deficiency impairs skeletal muscle growth in both humans and animals independently of decreased food intake. Insulin-like growth factor (IGF) is the primary regulator of postnatal muscle growth and there is substantial evidence that the effects of zinc deficiency alter IGF mediated muscle …
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The molecular memory of exercise in skeletal muscle
Skeletal muscle constitutes nearly half of our body weight and reduction of muscle mass is linked to increased risk of mortality and metabolic disorders. Further, skeletal muscle mass and function decline with age, a term known as sarcopenia. These reductions in muscle mass and function can be …
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The molecular memory of exercise in skeletal muscle
Skeletal muscle constitutes nearly half of our body weight and reduction of muscle mass is linked to increased risk of mortality and metabolic disorders. Further, skeletal muscle mass and function decline with age, a term known as sarcopenia. These reductions in muscle mass and function can be …
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