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Showing 1 to 3 of 3 for “"site-specific bioconjugation"”.

  1. Positron Emission Tomography in Oncology and Environmental Science

    Delaney, SamanthaThe Graduate School and University Center of The City University of New York2024

    … in hospitals and laboratories across the globe. Specifically, PET allows for the exquisite sensitive and specific detection of biomarkers with high spatial resolution and image contrast. This dissertation describes the use of PET and radionuclides for two purposes: 1) the development of novel …

    cuny-grad Repository record

  2. Carbon Monoxide Prodrugs for Targeted Cancer Therapy

    Černauskienė, IngaUniversity of Cambridge2025

    … via solid-phase peptide synthesis and subsequent site-specific bioconjugation to therapeutic antibodies. Trastuzumab–CO-prodrug conjugates were synthesised with CO-to-antibody ratios of up to an average of 23 and demonstrated tumour-specific CO release in HER2-overexpressing cells. The platform …

    cambridge Repository record

  3. Leveraging Bio-Inspired Molecules for Cancer Theranostics

    MacPherson, Douglas SThe Graduate School and University Center of The City University of New York2022

    … can be radiolabeled and delivered to a cancer site for the purposes of diagnostics and therapy. Among the most promising of tumor targeting molecules are peptides and antibodies. These bio-inspired molecules can be designed and synthesized to target and respond to cancer cells based on the …

    cuny-grad Repository record