Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"site-selective"”.
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Site-selective modification of cysteine residues
… modifications on proteins of interest, in a site-selective manner mimicking nature's post-translational modifications, for various biological and therapeutic applications. Towards this goal, efforts were devoted to develop site-selective protein modification methods. The [pi]-clamp-mediated …
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Site-Selective Anion Exchange in a Palladophosphorane
Reported here are studies on the chemoselective ligand substitution at a palladophosphorane possessing two potential sites of chloride substitution. Ligation of palladium(II) chloride with a tridentate chelating ligand (L, P(N(o-N(2-pyridyl)C₆H₄)₂) results in formation of a complex comprising a d⁸ …
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Site-selective C-H Bond Diversification of Glycosides
… with the ultimate goal of developing a general, selective and efficient catalytic system for monosaccharide functionalization: 1) site-selective halogenation & derivatization of sugars, 2) expedient synthesis of L-glucose and 3) diastereoselective C-H alkylation of sugars. These radical-based …
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Site-selective Labeling of the Nitrogenase Iron-Molybdenum Cofactor
… catalysis. Because the large number of metal sites present within FeMo-co gives rise to a complex set of spectroscopic responses, correlating that information to a specific metal site within the three- dimensional structure is a substantial challenge. My thesis is focused on addressing this …
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Reactive Peptides for Site-Selective Cysteine and Lysine Bioconjugation
Achieving catalyst-free, site-selective modification of proteins in water is a significant challenge in chemical biology. Issues of residue specificity, site-selectivity, reagent stability, and reaction rate are pervasive. To address these challenges, we developed a matched peptide pair termed the …
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Efforts Toward the Site-Selective Dehydrogenation of Saturated Fatty Acids
Studies toward the selective functionalization of saturated fatty acids using iridium carboxylate complexes are described. A variety of iridium complexes were developed bearing a coordinated carboxylate ligand. These complexes were submitted to known dehydrogenation conditions; however, …
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CYCLIZATION-BASED SITE-SELECTIVE N-TERMINAL CYSTEINE CONJUGATION, PEPTIDE STAPLING AND HISTONE DEACETYLASE (HDAC) PROBING
… still limited. This dissertation reports a stereoselective thiomorpholine ring formation reaction to site-selectively modify N-terminal cysteines of unprotected peptides or proteins in a single step. We showed that α-fluoroketone molecules afford the cyclization reaction with the beta amino thiol …
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Convergent Site-Selective Carbohydrate-Peptide Ligations With Dehydroalanine and Aziridine -2 -Carboxylic Acid-Containing Peptides
The development of two convergent strategies for site-selective peptide modification and their application to the preparation of alpha-thio analogs of mucin related glycoconjugates is described. Chemoselectivity in these reactions was realized through the incorporation of dehydroalanine and …
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Study of Nitrogenase Cofactors bound to Nitrogenase Carrier Proteins
… their cluster composition, featuring eight metal sites, at least seven of which are Fe. Understanding how these cofactors operate requires knowledge of their electronic structure in the resting state, and how they change during the catalysis. However, spectroscopically studying nitrogenase …
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Chemical Nanolithography and Single Molecule Optical Imaging With Metal -Coated Probes
… used as a surface to support nanolithography by site-selective chemical catalysis. Palladium-coated atomic force microscopy tips (AFM), scanned over the organosiloxane surfaces at loads over approximately 2.5 micronewtons, induced reactions of the terminal organic functional groups. These written …
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The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
… we will describe the development of a novel site-selective bioconjugation strategy using an innovative lysine-targeting reagent, PFP-bisN<sub>3</sub>, to prepare [<sup>89</sup>Zr]Zr-<sup>SSK</sup>DFO-pertuzumab for visualizing HER2+ breast cancer. Further, we introduce a new mAb with a …
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Effects of Immobilization Matrices and Protein Orientation on Biomolecular Recognition at Solid-Liquid Interfaces
… constructed on supported lipid membranes using a site-selective immobilization method. The orientation of the immobilized cytochrome b5 was well controlled as verified with linear dichroism measurements. The orientational dependence of the protein electrostatic surface potentials was observed by …
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Controlling Site-Selectivity in Palladium-Catalysed Cross-Coupling Reactions using Non-Covalent Interactions Between Ligand and Substrate
… synthesis. This thesis explores controlling the site-selectivity of palladium-catalysed cross-coupling reactions by using a non-covalent interaction between a ligand and substrate. A library of phosphine ligands were synthesised that incorporate an anionic or hydrogen bond acceptor group. They …
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Radical Tools to Transform Biomass Sugars
… on protecting group manipulations to achieve selective reaction outcomes. Currently, the lack of reliable and selective chemical tools to rapidly access diverse sugar building blocks presents a bottleneck in the synthesis and evaluation of unusual and unnatural sugars. New, selective methods …
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Understanding the Structure and Properties of Self-Assembled Monolayers for Interfacial Patterning
… soft lithography method of contact printing and site-selective reductive desorption. The electrochemical properties of homogeneous contact printed monolayers are measured and compared to those of monolayers prepared by solution adsorption. The contact printed monolayers are found to have …
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Particle Size Dependence on the Luminescence Spectra of Eu3+:Y2O3 and Eu3+:CaO
Since the Eu3+ ion can occupy different cation sites in a host material, it can serve as a useful probe of nanocrystalline structures to gain more insight into the structural changes that can occur when the particle size is reduced from the bulk to nanometer regime. The use of laser spectroscopy to …
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Manganese-catalyzed intermolecular benzylic C–H amination
… biological properties of a given molecule. While selective intramolecular C—H amination reactions are known, intermolecular C—H amination reactions with high reactivity and selectivity are scarce. Achieving high levels of reactivity while maintaining excellent site-selectivity and functional group …
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Dearomative functionalization of simple arenes: Reduction and palladium-catalyzed syn-1,4-aminofunctionalizations
… for non-activated arenes which would allow site-selective introduction of functionality with concomitant loss of aromaticity would provide ideal platforms for accessing alicyclic structures with functional and stereochemical diversity. To this end, this thesis is based on the development of …
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