Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"single-unit recordings"”.
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Regulation of dorsal raphe serotonergic neurons by histamine
… of serotonergic neurons.<br/><br/>In vitro, single-unit recordings from putative serotonin (5-HT) neurons revealed that these neurons fired spontaneously in acute brain slices taken from mice. Initial pharmacological investigations revealed that putative 5-HT neurons in the DRN were under …
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Contrast adaptation reveals increased organizational complexity of chromatic processing in the visual evoked potential
Results from psychophysics and single-unit recordings suggest that color vision comprises multiple stages of processing. Post-receptoral channels appear to consist of both a stage of broadly-tuned opponent channels that compare cone signals, and a subsequent stage, which includes cells tuned to …
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Characterizing Neurotransmitter Receptor Activation with a Perturbation Based Decomposition Method
… diagnosis and study of neurological disorders. Single-unit recordings provide a method of measuring postsynaptic potentials in neurons using a microelectrode system, but yield no detailed information regarding the neurotransmitter receptors that contribute to the potential. To determine the …
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Neurophysiological studies of the response characteristics of auditory fibres in the cricket (Gryllidae orthoptera) with particular reference to Teleogryllus oceanus, (le guillou)
Single unit recordings of primary and central auditory fibers of the cricket Teleogryllus oceanicus show responses to frequencies over the range 1kHz to at least 42kHz. The characteristic frequencies, (ChFs) of units were distributed over most of the bandwidth investigated although few units were …
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Investigating prefrontal cortex neuronal signatures of opioid-induced risk-taking behavior
… avoidance (referred to as Risk-Avoiders). Single-unit recordings from the prelimbic cortex (PL) demonstrated decreased neuronal activity upon acute morphine exposure in both Risk-Takers and Risk-Avoiders, but this firing rate suppression was absent after repeated morphine administration. …
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Mapping the neural circuits that underlie metabolic vs. emotional regulation of food-seeking behavior
… of predator-related odor. Next, by using in vivo single-unit recordings from projection-defined neurons in the prelimbic cortex (PL), an input source of aPVT<sup>CRF</sup> neurons, and chemogenetic manipulations of distinct PL circuits, we found that divergent PL projections to the PVT or the NAc …
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Overexpression of Serum Response Factor in Astrocytes Improves Neuronal Plasticity in a Model of Fetal Alcohol Spectrum Disorders
… Using optical imaging of intrinsic signals and single unit recordings we observed that overexpression of a constitutively active form of SRF (Sindbis SRF+), but neither its dominant negative (SRF-) nor GFP, restored OD plasticity in alcohol-treated animals. Surprisingly, this restoration was …
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The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… spinal hyperexcitability during extracellular single-unit electrophysiological spinal recordings from the dorsal horn of the lumbar enlargement (below-level), thoracic cord (at-level; immediately rostral to injury site), and brachial enlargement (above level). \r\n In models of peripheral …
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The effects of repeated amphetamine exposure during adolescence on behavior and prefrontal cortex function
… on medial PFC neurons was assessed using single-unit recordings in awake behaving rats. Young adult rats were challenged with amphetamine followed by a D1 or D2 receptor antagonist. The proportion of amphetamine-responsive neurons and the pattern of spike activity was altered in animals …
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The mouse visually evoked potential : neural correlates and functional applications
… response to visual stimuli. Unlike extracellular single unit recordings, which allow us to probe the function of single spiking cells acutely, the chronic VEP technique gives us insight into ensemble synaptic activity. However, while action potentials are easily interpreted as the output of the …
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The role of basal ganglia-forebrain circuitry in the vocal learning of songbirds
… in this variability. In addition, the first single-unit recordings of AFP output neurons in singing juvenile birds reveal little correlation with plastic song and a premotor correlation with the most variable form of singing, subsong. These results suggest a novel function for basal …
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Mechanisms of pain processing: spinal protein translation in the rat
… was used to obtain extracellular single unit recordings of spinal cord lamina V wide dynamic range (WDR) neurones that respond to innocuous and noxious stimuli to peripheral sites i.e. the rat hind paw; behavioural studies were used to assess the progression of pain-like states and …
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Spatial-memory control of defensive actions
… shelter during escape, I performed simultaneous single-unit recordings from the RSC and SC with Neuropixels probes. Both RSC and SC were found to encode the angular offset between the mouse’s heading and the shelter, at the single-neuron and population levels. Chemogenetic inactivation of …
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Generation and tuning of learned sensorimotor behavior by multiple neural circuit architectures
… first section re-analyzes a large data set of single-unit recordings in zebra finch area HVC during singing. While HVC is known to be essential for proper expression of adult vocalization, its circuit architecture is contentious. Evidence is presented against the recently postulated …
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Repeated amphetamine exposure and the enduring consequences on behavioral and neural plasticity
… (PFC) function. In experiment 1 (Chapter 5), single-unit recordings from actively behaving rats were used to examine the relationship between the locomotor response (i.e., the ability to induce sensitization) and medial PFC (mPFC) firing activity to repeated AMPH treatment. The results …
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The role of locus coeruleus norepinephrine in reinforcement learning
… in target regions, we performed high density single unit recordings in motor and prefrontal cortices while silencing the LC on a subset of trials. We found that LC-NE activity following an air-puff punishment changed population activity in the cortex such that the population representation of …