Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"single-molecule DNA sequencing"”.
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Advancing Technologies for Precision Medicine: From Liquid Biopsy to Single-Molecule DNA Sequencing
… liquid biopsy assays with an emerging single-molecule nanopore sequencing platform to address limitations associated with conventional tissue biopsies and DNA sequencing technologies in cancer care. First, we demonstrated the potential of circulating tumor cells (CTCs) as a minimally …
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On single-molecule DNA sequencing with atomic force microscopy using functionalized carbon nanotube probes
A novel DNA sequencing method is proposed based on the specific binding nature of nucleotides and measured by an atomic force microscope (AFM). A single molecule of DNA is denatured and immobilized on an atomically fiat surface, and a force probe functionalized with a nucleotide is scanned along …
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Self-Assembly of a Bio-Driven Single Molecule DNA Sequencer
DNA sequencing reads the order in which the four nucleotide bases – adenine (A), thymine (T), cytosine (C) and guanine (G) – arrange into the long biopolymer that encodes the genes of all living organisms. The ability to sequence DNA has revolutionised the biological sciences and is having a …
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A Pan-Cancer Single-Cell Analysis of Intratumoral Copy Number Diversity and Evolution
… Acoustic Cell Tagmentation (ACT), an advanced single-cell single-molecule DNA sequencing (scDNA-seq) technology, to resolve the copy number substructure of human tumors and investigate the evolution of aneuploidy. Applying ACT to eight triple-negative breast cancer (TNBC) patients to profile …
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From Micro- to Nano-Scale: Applications of Solid-Phase Enzymatic Reactors for Biopolymer Disassembly
… nanoscale on-chip digestion of double-stranded DNA. Enzyme immobilization in both studies was successfully accomplished using 3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling to carboxylic acid functionalized PMMA micropillars. Our micro-scale results suggest that …