Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"single-cell phylogenies"”.
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Inferring tumour evolution from single-cell and multi-sample data
… as an evolutionary process during which cells accumulate mutations and evolve into a mix of genetically distinct cell subpopulations. The resulting genetic intra-tumour heterogeneity poses a major challenge to cancer therapy, as it increases the chance of drug resistance. To study tumour …
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Characterising the evolutionary dynamics of hypermutated tumours using single-cell sequencing
… for MMRD cancers. Recently, the advent of single-cell (WGS) methodologies allowed for the assignment of mutations to individual cells, making the reconstruction of single-cell lineage histories possible. As a first contribution in my PhD, I have reconstructed the phylogenetic history of …