Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"single-cell multiome"”.
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The Role of the Transcription Factor CEBPA in Regulating Lung Alveolar Type 2 Cell Fate In Vivo
<p>Cell plasticity can extend across all possible cell types, yet it naturally diminishes as cells progress through differentiation. This plasticity can be reactivated during injury repair, engaging developmental flexibility. Our investigations reveal the critical role of the transcription factor …
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Bioinformatic Approaches to Study Mitochondrial DNA Heteroplasmy
… they are primarily responsible for producing cellular energy and contain multiple copies of their own small, circular DNA, known as mitochondrial DNA(mtDNA). Mutations in mtDNA can be maternally inherited or somatic, when they occur after fertilisation. There are mechanisms at both the extra- …
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Genetic analysis of Kmt2d loss in tumorigenesis using genetically engineered mouse models
… carcinoma. Biochemically, KMT2D shapes the cellular enhancer landscape as the major writer of the putative enhancer mark H3K4me1. Given the critical role of cellular enhancer landscape in determining cellular lineage in embryonic development, it is unknown whether enhancer dysregulation …
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Single-cell genomics in rabbit and mouse elucidate eutherian embryonic development
… accessibility profiles of almost 180,000 single cells and high-resolution histology sections from embryos spanning gastrulation, implantation, amniogenesis, and early organogenesis. Using a novel computational pipeline, we compare the transcriptional landscape of rabbit and mouse at the …