Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"single-cell RNA sequencing analysis"”.
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… relapse may arise from disseminated tumor cells (DTCs) that undergo a period of dormancy before reactivating and progressing to life-threatening disease. How cancer cells evade ensuing immune surveillance upon reactivation is poorly understood, but critical for the development of novel …
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Elucidating how mutations in EIF2AK4 cause pulmonary vascular disease
… genetic ablation of interleukin 6. Preliminary single-cell RNA sequencing analysis of lung cells from *gcn2<sup>-/-</sup>* mice shows potential upregulation of pro-inflammatory pathways in *gcn2<sup>-/-</sup>* macrophages and fibroblasts. I have shown, for the first time, that …
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Investigating the role of endoplasmic reticulum stress in neutrophils during tumour initiation
Neutrophils are pivotal innate immune cells conventionally recognised for their rapid response to infection sites. In recent years, immune suppressive and tumourpromoting neutrophils were found enriched in the tumour microenvironment, suggesting their role in driving the development of cancer. …
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BUBR1 in Cardiac Biology: From Cardiogenesis to Adult Heart Function and Aging
… in cardiac morphogenesis, cardiac aging, intercellular communication, and wound healing, uncovering novel regulatory pathways that contribute to both developmental and degenerative cardiac conditions. Our findings demonstrate that BubR1 is indispensable for embryonic cardiac development. …
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A multi-lineage in vitro mouse embryo model derived exclusively from mouse embryonic stem cells
… and yolk sac respectively. By using stem cells derived from these three fundamental lineages, many *in vitro* models have been developed to recapitulate various events of post-implantation development. Using only mouse embryonic stem cells (ESCs), the gastruloid model has been demonstrated …
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Development Of Regulatory T Cells Capable Of Maintaining Immune Homeostasis
The adaptive immune response, comprised of both T cells and B cells, is essential to control infections and eliminate transformed cancer cells. The success of the adaptive immune system relies on the ability to discriminate self from non-self-antigens. The thymus is the site of selection for T …
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Defining Epithelial Cell Fate Dynamics of the Oesophagus during Postnatal Development and Homeostasis
Epithelial cells can respond rapidly to changing tissue demands to ensure organism survival. However, the mechanisms that finely control how cells adapt their behaviour remain largely unknown. To uncover the rules that govern epithelial cell fate, it is critical to understand their dynamic nature …
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Charting the single-cell transcriptional landscape of haematopoiesis
… system is sustained by stem and progenitor cells, which divide and mature to produce the range of cell types present in the blood. This complex system has long served as a model of differentiation in adult stem cell systems and its study has important clinical relevance. Maintaining a …
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Derivation of next generation research models of Parkinson’s disease
… region of the midbrain and the presence of intracellular inclusions, notably Lewy bodies composed of the alpha-synuclein protein (encoded by the SNCA gene), in the surviving neurons. The precise molecular and cellular mechanisms governing PD's onset, progression, and pathology remain incompletely …