Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"single-cell ATAC-seq"”.
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Leveraging Single-Cell ATAC-Seq for Genomic Language Models and Multimodal Foundation Models
Single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) has emerged as a powerful tool for profiling chromatin accessibility at single-cell resolution. By capturing epigenomic landscapes, scATAC-seq provides critical insights into the regulatory elements that govern …
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Droplet-Based Microfluidics for High-Throughput Single-Cell Omics Profiling
… is a powerful tool permitting massive-scale single-cell analysis in pico-/nano-liter water-in-oil droplets. It has been integrated into various library preparation techniques to accomplish high-throughput scRNA-seq, scDNA-seq, scATAC-seq, scChIP-seq, as well as scMulti-omics-seq. These …
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EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿
… to investigate the earliest molecular and cellular alterations that precede the disease. To dissect early events, a transgenic PML-RAR model was used in combination with high-resolution single-cell technologies. Hematopoietic stem cells (HSCs), common myeloid progenitors (CMPs), and a …
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Understanding Gene Regulation In Development And Differentiation Using Single Cell Multi-Omics
… My thesis research leverages powerful single-cell approaches to address this fundamental question in two developmental systems, C. elegans embryogenesis and mouse embryonic hematopoiesis. I have also developed much-needed computational algorithms for single-cell data analysis and …
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Using a novel large-scale epigenetic analysis method to uncover the cis-regulatory potential of individual transposable elements
Transposable elements (TEs) are DNA sequences with the potential to move or replicate and insert themselves at new genomic locations. Over evolutionary time, many sequences derived from TEs have accumulated and account for 50% of the human genome. These mobile elements were initially considered …