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Showing 1 to 3 of 3 for “"single particle electron microscopy"”.
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Network modularity and local environment similarity as descriptors of protein structure
… in de novo protein design, or in fitting electron density maps derived from single particle electron microscopy. The second method calculates a descriptor for each atom of the protein based on its local environment, known as a Smooth Overlap of Atomic Positions (SOAP) descriptor. Using …
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Revealing Molecular Adversaries of Human Health Using Advanced Imaging Technology
Single particle electron microscopy (EM) allows us to examine the molecular world and gain insights into protein structures implicated in human disease. Visualizing the 3D architecture of the macromolecules can inform drug design and preventative care. While X-ray crystallography and NMR are able …
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Elektronenmikroskopische 3D Strukturbestimmung des Spleißosoms
… fünf snRNPs (`small nuclear ribonulceoprotein particles´) und weiteren Faktoren aufgebaut. Der spleißosomale Komplex A, bestehend aus U1 und U2 snRNP, verbindet sich mit dem U4/U6.U5 tri-snRNP, einem Komplex der U4, U5, U6 snRNPs, um den prä-katalytischen Komplex B zu bilden. Nach der …