Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 727 for “"single molecule"”.
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Laser-assisted single-molecule refolding
… we have developed a new technique combining single-molecule FRET detection with laser induced temperature jump. We have calibrated the magnitude of the temperature jump with 1˚C accuracy using gold micro-size sensor. The accuracy of temperature calibration was confirmed by close agreement …
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New routes to single molecule magnets
… are of particular interest for the generation of single molecule magnet (SMM) behaviour. The product family includes a Co4 SMM cluster, a Co6 SMM cluster and a 3D network of linked SMM units. A new route to the erinaceous Co6 cluster crystals is reported, which allows further investigation of the …
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Signal Processing In Single Molecule Studies
… processing techniques used in investigating single molecule kinetics and interactions. The first chapter provides an overview of signals and systems pertaining to single molecule studies. It discusses the need for signal processing, and gives a summary of current single molecule techniques. …
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Magnetization dynamics of single molecule magnets
Made available in DSpace on 2014-09-16T17:25:53Z (GMT). No. of bitstreams: 2 Yun_Liu.pdf: 2936489 bytes, checksum: 870b4bdf8c282c749cf14f4925088600 (MD5) license.txt: 4056 bytes, checksum: c0d6bd6324ecaf18c5d2647589f9beff (MD5)
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Single molecule investigation of antiviral signaling
… to antagonize viral invasion. We utilized single-molecule fluorescence in situ hybridization (smFISH) to study viral and antiviral gene expression in individual cells. We precisely quantified kinetics of mRNA expression of RIG-I with respect to IFN- in cells upon infection with Sendai …
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Single molecule studies of helicase mechanisms
… resolutions, as well as the ability to look at molecules one at a time instead of in an ensemble, have been shown to be helpful in elucidating the specific actions in many biological systems. Single molecule FRET (smFRET) microscopy provides these abilities with a distance scale of 2-8 nm, 8 ms …
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Single Molecule Study of Polymer-Surfactant Interactions
… constant MC concentration the diffusion time of single aggregates increases gradually up to a certain SDS concentration and decreases to a minimum when the SDS concentration is further increased. This behavior coincides with the behavior of the zero shear viscosity. Two different fractions viz …
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Image Deconvolution Techniques for Single Molecule Studies
… is the need to analyze information from single proteins as opposed to ensembles of many molecules. Consequently, the advent of high-resolution imaging in single molecule microscopy has enabled researchers to probe the underlying processes of gene regulatory networks and other biological …
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Single-molecule imaging studies of protein dynamics
Single-molecule fluorescence imaging is a powerful method for studying biological events. The work of this thesis primarily focuses on single molecule studies of the dynamics of Green Fluorescent Protein: GFP) and other fluorescent-labeled proteins by utilizing Total Internal Reflection …
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Single molecule studies of rna-target interactions
<p>We have used FRET, single molecule spectroscopy, and several other biophysical techniques to study how the folding of RNA allows it to perform its various functions by recognizing and binding a target ligand. We have shown that the c-di-GMP riboswitch undergoes a large, global conformational …
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Single Molecule Junction Conductance and Binding Geometry
… studying electronic and mechanical properties of single organic molecule-metal junctions. Using a Scanning Tunneling Microscope (STM) we image, probe energy-level alignment and perform STM-based break junction (BJ) measurements on molecules bound to a gold surface. Using Scanning Tunneling …
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Single molecule studies of branched polymer dynamics
… properties for topologically complex polymers. Single molecule studies enable the direct observation of polymer chain dynamics at the molecular level; however, the vast majority of single polymer studies have only focused on linear DNA molecules (Chapter 2). In this dissertation, we extend …
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Single molecule fluorescence studies of replicative helicases
… into mechanical energy for translocation on single stranded (ss) DNA and unwinding of double stranded (ds) DNA. All of the 12 known replicative helicases are hexameric helicases that are ring-shaped in structure and are homohexamers with the exception of the eukaryotic minichromosomal …
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Single molecule studies of flexible polymer systems
… of polymer solutions is not fully understood. Single molecule studies of polymer solutions provide an avenue for studying polymer dynamics and can aid in developing new molecular models of dynamic behavior. For nearly two decades, fluorescentlylabeled double stranded DNA (dsDNA) has been the …
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Single molecule fluorescence studies of biomolecular interactions
Single molecule fluorescent techniques have become standard approaches to study protein-DNA interactions. However, these techniques have largely been confined by limitations in assays to studying the interaction between simple DNA substrates and a single protein. During my PhD I developed several …
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Biophysical Applications of Single Molecule Fluorescence Localization
Fluorescence single molecule localization has become a powerful tool for investigating problems in biological physics. However, there are numerous limitations on the types of measurements that can be made with typical instrument designs based on objective-type TIR and wide field CCD imaging. We …
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Single molecule fluorescence microscopy of carbon nanotubes
Single molecule microscopy has been extensively used in the past decade to study individual biomolecules with excellent spatial and temporal resolution. Meanwhile, characterization of nanomaterials and their development towards a variety of biological applications has progressed rapidly. Despite …
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Single-molecule dynamics of GPCR signal transducers
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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