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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 125 for “"single domain"”.

  1. Generating single-domain antibodies against fibronectin splice variants

    Peterson, Alexis WMassachusetts Institute of Technology2017

    Here, I describe the process of generating single-domain antibodies which bind to splice variants of fibronectin containing EIIIA or EIIIB. Alpacas were immunized with either purified antigen cocktails, or from the ECM of tumor samples, and antibody libraries were generated. Using these libraries …

    mit Repository record

  2. Magnetism and interactions within the single domain limit: reversal, logic and information storage

    Li, Zheng2016

    … a function of length, corresponding to the multi-single magnetic domain transition. From an industrial point of view, the application of magnetic interaction within the single domain limit has been proposed and studied in the context of magnetic recording and information processing. In this …

    washington Repository record

  3. Isolation and Characterization of Anti-SLP Single Domain Antibodies for the Therapy of C. difficile Infection

    Kandalaft, HibaUniversité d'Ottawa / University of Ottawa2012

    … characterized 11 SLP-specific recombinant single-domain antibodies (sdAbs), in terms of affinity and specificity, intrinsic stability, and ability to inhibit cell motility. Several sdAbs exhibit promising characteristics for a potential oral therapeutic based on their high affinity, high …

    ottawa-retro Repository record

  4. Over-expression in Escherichia coli of the ToxA51 llama single domain antibody targeting Clostridium difficile enterotoxin A

    Parisien, AlbertUniversity of Ottawa (Canada)2013

    Single domain antibodies (sdAb) have emerged as a family of novel antibodies that have vast applications. Of particular relevance, ToxA5.l, a sdAb capable of binding to, and therefore neutralizing, Clostridium difficile toxin A (TcdA) has been developed. The antibiotic resistant version of C. …

    ottawa-retro Repository record

  5. Studies on the interaction of a single domain of protein G from streptococcus with human Fc and Fab

    Muir, NicolaUniversity of Southampton2009

    … have been determined in order to generate SpG domains with a range of binding affinities for biotechnological uses. SpG species that only bind to Fc or Fab have also been developed. The mutant W42F has been shown by ITC studies to have lost the ability to bind to Fc, and the double mutant …

    soton Repository record

  6. INVESTIGATION OF THE RESISTANCE TO DEMAGNETIZATION IN BULK RARE-EARTH MAGNETS COMPRISED OF CRYSTALLOGRAPHICALLY-ALIGNED, SINGLE-DOMAIN CRYSTALLITES WITH MODIFIED INTERGRANULAR PHASE

    Li, Jie

    mtu Repository record

  7. Magnetic Logic Gate Using Ferromagnetic Hexagonal Nanodots

    Liu, LongchenGraduate Studies2014

    … all hexagonal nanodots. A new boundary between single domain and vortex state on the dependency of uniaxial shape anisotropy has been discovered. Based on the characterized magnetic state of each hexagonal nanodot, several acceptable magnetic switching performances were obtained from hexagonal …

    calgary Repository record

  8. Online Adaptive Neural Machine Translation: from single- to multi-domain scenarios

    Farajian, Mohammad AminUniversità degli studi di Trento2018

    … MT adaptation under two working conditions: single-domain and multi-domain. In the former, we assume that MT receives requests by a single user working on a single domain, while in the latter we assume the MT system to receive requests i) from multiple users working on different domains, ii) …

    trento Repository record

  9. Análise de problemas conjugados em microssistemas térmicos com múltiplas correntes e geometrias complexas via transformação integral

    Zotin, José Luiz ZanonUniversidade Federal do Rio de Janeiro2017

    … Integral Transformation Technique (GITT) using a single-domain reformulation with a total transformation scheme for problems of conjugated heat transfer in thermal micro-systems with flows of immiscible fluids in direct contact, multiple currents and microchannels of complex geometric …

    brazil-uerj Repository record

  10. Rational Design and Application of Antibodies for Amylin and Amyloid Beta

    Lin, JiachengUniversity of Cambridge2023

    … method to successfully increase the potency of a single domain antibody by over 200-fold against Aβ42 aggregation. Utilizing display techniques and chemical modification can further enhance the binding affinity and specificity of these antibodies, making them a more viable treatment option. …

    cambridge Repository record

  11. Layer-by-Layer Single-crystal Two-dimensional Material Growth by Geometric Confinement

    Lee, DoyoonMassachusetts Institute of Technology2023

    … control during their growth, 2) maintaining single crystallinity at wafer-scale, and 3) inevitable transfer-process to fabricate heterostructure for various next-generation applications such as spintronics, valleytronics, and optoelectronics. This thesis introduces a confined-growth technique …

    mit Repository record

  12. Effect of disruption of 3D8 complementarity-determining regions on properties of 3D8 antibody

    이, 지연2012

    … on the function of an antibody, 3D8 scFv (single chain variable fragment; variable region of heavy chain connected to variable region of light chain by (G4S1)3 linker) which has DNA-binding/-hydrolyzing, heparin-binding and cell-penetrating activities. We generated single CDR-disrupted …

    ajou Repository record

  13. Design and Investigation of Genetic Algorithmic and Reinforcement Learning Approaches to Wire Crossing Reductions for pNML Devices

    Gunter, Alexander Keith2020

    … which encodes binary data in the polarization of single-domain nanomagnets and performs operations via fringing field interactions. Currently, there is no complete top-down workflow for pNML. Researchers must instead simultaneously handle place-and-route, timing, and logic minimization by hand. …

    mississippi Repository record

  14. Magnetic susceptibility mapping of Point Pelee National Park beaches.

    Igbokwe, Blessing A.University of Windsor2005

    … throughout the Point Pelee beaches is pseudo single domain to single domain magnetite. Some variation in composition is apparent. Similar compositions and grainsize were observed to the north east of PPNP, on the Rondeau Provincial Park beaches and Wheatley beaches, suggesting either the same …

    windsor Repository record

  15. ΓΕΩΜΑΓΝΗΤΙΚΕΣ ΜΕΛΕΤΕΣ ΣΕ ΛΙΜΝΑΙΑ ΙΖΗΜΑΤΑ

    Παπαμαρινόπουλος, ΣταύροςInstitutes outside Greece1978

    … OF THE FINE GRAINED MAGNETITE IN DOMINANCE OF SINGLE DOMAIN OR PSEUDOSINGLE DOMAIN IN CHARACTER WHEREAS MAGNETIC EXTRACTS STUDIES (DEBYE-SCHERER X-RAY, DIFFRACTOMETRY, THERMOMAGNETIC EXPERIMENTS, MOSSBAUER SPECTROSCOPY AND OPTICAL MICROSCOPY) SHOWED THE PRESENCE OF ANGULAR FRESH MAGNETITE OR …

    greece Repository record

  16. Development of VHH- and antibody- based imaging and diagnostic tools

    Li, ZeyangMassachusetts Institute of Technology2018

    … a site for labeling in a controlled manner. Single-domain antibodies (VHHs) from camelids are amongst the smallest (15 KDa) proteins that can recognize a diverse set of targets with excellent specificity. Chemoenzymatic labeling of molecules using sortase allows site-specific attachment of a …

    mit Repository record

  17. Heterogeneous internal fabric of the Mount Barcroft pluton, White Mountains, of eastern California: an anisotropy of magnetic susceptibility study

    Michlesen, Karen JoyceVirginia Tech2004

    … AMS analysis. Microstructure identification of single thin sections prepared for each sample site yielded primarily magmatic with minor solid-state structures. A highly heterogeneous distribution of scalar parameters (Km, P%, F%, L%, T) was documented both between sample sites and between the A …

    vt Repository record

  18. Structural analysis of LMO2 for the development of a small molecule inhibitor

    Sewell, HelenUniversity of Leeds2010

    … LMO2 was co-expressed with an antibody single domain termed VH#576, and purified to a high yield and purity. A final construct of LMO2, spanning residues 9 to 147, bound to VH#576 has been crystallised and the structure solved, to a medium resolution of 3.3Å, using phase information from …

    whiterose Repository record

  19. Engineering functional recombinant proteins based on antibody domains and fragments of C. botulinum neurotoxin

    Tolkacz, JOxford Brookes University2010

    … molecules. The focus of this study is single chain Fv (Fragment variable) and single domain antibodies. Recombinant botulinum neurotoxin fragments derived from serotype A, B, C and D are selected as backbones for an investigation into the feasibility and properties of novel recombinant …

    oxford-brookes Repository record

  20. Multiphase Modeling of a Flowing Electrolyte-Direct Methanol Fuel Cell

    Ouellette, DavidCarleton University2016

    … Mixture Model (MMM) was improved with a new single domain approach which was used to model the flow behaviour and performance of the FE-DMFC. Unlike the existing methods, the proposed model only requires the mixture variables, thereby removing the requirement for information about the gaseous …

    carleton Repository record

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