Global ETD Search
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Showing 1 to 12 of 12 for “"single channel conductance"”.
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Isolation and characterization of channel-forming proteins in the outer membrane of E. coli and Borrelia species
… in the black lipid bilayer assay. Histograms of conductance fluctuations were obtained from single-channel experiments with outer membrane preparations of B. hermsii, B. recurentis and B. duttonii. All strains had a different conductance fluctuation pattern with a broad range of single-channel …
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Functional Characterization of Hippocampal Synapses in a Mouse Mutant of the Dystrobrevin Binding Protein 1 (DTNBP 1) Gene
… observed in hippocampal preparations. Enhanced single channel conductance in the AMPA receptor did not appear to contribute to the increase of evoked CA1 AMPA receptor transmission. Indeed neither changes in the proportion of AMPA receptors lacking GluR2 subunit, which have a high single channel …
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Bilayer Network Modeling
… individual aqueous volumes are separated by single bilayers like the droplet-interface-bilayer. Applied potentials in one of the aqueous volumes will propagate through the system creating membrane potentials across the bilayers of the system and ion currents through the membranes when …
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Channel-forming proteins in the cell wall of amino acid-producing Corynebacteria
… in the outer membrane of Gram-negative bacteria, channels are present in the mycolic acid layer of the mycobacterial cell wall for the passage of hydrophilic solutes. Molecular studies have provided far-reaching findings on the amino acid flux and its balance in C. glutamicum in general, but the …
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Pharmacological and Pharmacokinetic Studies of a K<sub>Ca</sub>2.2 Positive Allosteric Modulator
<p>Small-conductance Ca<sup>2+</sup>-activated potassium channels (K<sub>Ca</sub>2.x) family is widely expressed in neurons, the heart, and endothelial cells. K<sub>Ca</sub>2.x channels are named small conductance Ca<sup>2+</sup>-activated potassium channels due to their comparatively low …
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Regulation of sodium channel densities in A6 renal epithelial cells by hormonally-dependent mechanisms
Epithelial sodium channels (ENaC) located in the apical membranes of transporting epithelia, such as cells of the renal distal nephron, constitute the rate limiting step in the transcellular transport of sodium. The regulation of sodium ion reabsorption in the kidney, which is essential for salt …
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Computational analyses on the structure-function relation in ion channels
Ion channels are protein molecules, embedded in the lipid bilayer of the cell membranes. They act as powerful sensing elements switching chemicalphysical stimuli into ion-fluxes. At a glance, ion channels are water-filled pores, which can open and close in response to different stimuli (gating), …
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Single channel studies on the modulation of connexin hemichannels by Cx43 targeting peptides and cytoplasmic Ca2+ in the context of heart disease
In vertebrates, connexin hemichannels in the plasma membrane dock head-to-head with their counterparts in adjacent cells to form gap junction channels, allowing direct cell-cell transfer of electric and chemical/metabolic signals. Each hemichannel comprises a hexamer of connexin proteins which …
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Functional and Biochemical Characterization of KCNQ1/KCNE1 Subunit Interactions in the Cardiac IKs Potassium Channel
The IKs potassium channel, critical to control of heart electrical activity, requires assembly of pore-forming alpha subunits (KCNQ1) and accessory beta (KCNE1) subunits. IKs is the slowly activating component of delayed rectifier K+ current in the heart and is a major contributor to the timing of …
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The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Channel: Anion Permeation, and Regulation by Adenylyl Cyclase and ATP Hydrolysis
<p>CFTR Cl<sup>-</sup> channel function and regulation were studied in guinea-pig ventricular myocytes, using either the whole-cell or excised inside-out patch configurations of the patch clamp technique. A typical myocyte cell membrane contained a total of ~1400 CFTR channels; channel density was …
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Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
Pentameric ligand-gated ion channels (pLGICs) are a superfamily of neurotransmitter-gated ion channels, that includes (in vertebrates) the nicotinic Acetylcholine Receptor (AChR), Serotonin Receptor type 3 (5-HT3R), γ-Aminobutyric acid Receptor type A (GABAAR), and the Glycine Receptor (GlyR). All …
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Properties of Conductance and Inhibition of Proton Channels: M2 from Influenza A Virus and Fo from Escherichia coli ATP Synthase
<p>Proton channels are essential for many of the processes of life. The influenza A viral protein M2 is responsible for sensing the conditions necessary for viral RNA release. The proton-translocating FoF1 ATPase (ATP synthase) uses a proton gradient to drive adenosine triphosphate (ATP) synthesis. …