Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"single cell multi omics"”.
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Decoding Human T Cell Immunity With Single-Cell Multi-Omics
… work, I explore human adaptive immunity through single-cell omics by jointly analysing T cell gene expression and T cell receptor (TCR) sequence modalities. Across several longitudinal infectious disease studies, I identify transient T cell states after infection and link these phenotypes with …
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Resolving Intra-Tumoral Heterogeneity of Breast Cancer Using Single-Cell Multi-Omics
… challenge in cancer biology. Here, we leverage single-cell multi-omics technologies to dissect the cell states and gene expression programs underlying breast cancer heterogeneity, with a focus on triple-negative breast cancer (TNBC) and estrogen receptor-positive (ER+) breast cancer.</p> <p>In …
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Understanding Gene Regulation In Development And Differentiation Using Single Cell Multi-Omics
… My thesis research leverages powerful single-cell approaches to address this fundamental question in two developmental systems, C. elegans embryogenesis and mouse embryonic hematopoiesis. I have also developed much-needed computational algorithms for single-cell data analysis and …
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Statistical methods for the integrative analysis of single-cell multi-omics data
Single-cell profiling techniques have provided an unprecedented opportunity to study cellular heterogeneity at the molecular level. This represents a remarkable advance over traditional bulk sequencing methods, particularly to study lineage diversification and cell fate commitment events in …
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More than the sum of parts: deconstructing tissues in their spatial, temporal, and environmental contexts
The human body is composed of ~37,000,000,000,000 cells, exquisitely organized into tissues delivering emergent functions beyond individual cells’ capabilities (e.g., the brain’s seemingly-effortless computations, the liver’s wide-ranging chemical processing). In my PhD, I studied how healthy …
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Informatics Strategies for Alzheimer’s Disease Research Through Analyzing Genetics and Neuroimaging Data
… employing informatics strategies within the Genomics, Molecular Multiomics, Biomarkers, and Outcomes (GMBO) framework to integrate large-scale biobank data and uncover key disease mechanisms. Through computational approaches, this work bridges genetic, molecular, and neuroimaging data to address …
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Eomes Directs the Formation of Spatially and Functionally Diverse Extra-Embryonic Mesoderm Derived Tissues
… embryonic development, the first mesodermal cells to originate at the posterior primitive streak will give rise to the extra-embryonic mesoderm (ExEM). These cells will contribute to key tissues supporting the development of the embryo, including the amnion, chorion, yolk-sac, and allantois. …
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Single-cell Protein-Transcriptome Atlas of Haematopoiesis across the Human Lifespan
… the continuous production of stem and progenitor cells, which divide and mature to produce a wide variety of specialised circulating blood cells. Proper regulation of lineage decisions is key to ensure the right balance between the generation of differentiated cells and the maintenance of the …