Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"single cell atlas"”.
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Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
… after metastases. In this study, we used single-cell RNA transcriptome sequencing to characterize the cellular and molecular features of primary CRC and colorectal liver metastases (CRLM). Analysis of 130 samples revealed significant heterogeneity in the tumor microenvironment (TME) …
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Single Cell Methods to Learn Transcription Factor Interactions and Necessary Noncoding DNA During Zebrafish Somitogenesis
… function in vivo and how TFs cooperate to drive cell fate decisions remains incomplete and limited in scope. In this thesis, I will present a method sciPlex ATAC-seq, a multiplexed low cost method for single-cell assay for transposable accessible chromatin. Pairing this method with sciPlex …
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Cross-species single-cell transcriptomics and its applications in evolutionary and translational research
Single-cell transcriptomics has emerged as a powerful technology to characterise gene expression within individual cells. Over the last 5 years, as the technology has matured, single-cell techniques have been used to profile cells in species across the tree of life. The availability of single-cell …
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Resolving developmental dynamics using single-cell sequencing data
… disrupted form in disease. Over the past decade, single-cell sequencing has become one of the key technologies to generate high resolution in vivo snapshots to study developmental trajectories. After giving an overview of the current state of single cell technologies and computational methods, I …
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Understanding Development of Human Immunity One Cell at a Time
The emergence of single-cell and spatial multi-omic technologies has revolutionized our understanding of the immune cells. The international Human Cell Atlas consortium has spearheaded and coordinated a global effort to construct atlases of human tissues across multiple developmental stages. This …
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Combining population-scale single-cell transcriptomics with germline genetics to understand the biology of inflammatory bowel diseases
… to CD, UC, or IBD. Simultaneously, single- cell transcriptomic studies have extensively mapped the cell types present in the mostly commonly afflicted regions - the small and large intestines. Thusfar the efforts to align these two fields have been minimal despite the large benefit …