Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"single cell RT-PCR"”.
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Development of one-step single-cell RT-PCR for the massively parallel detection of gene expression
… Highly active antiretroviral treatments (HAART) that use a combination of drugs that target the virus at different stages of its life cycle are effective at reducing the HIV plasma levels below levels detectable by the most sensitive assays. However, upon termination of HAART, HIV RNA …
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Quantification and Molecular Characterization of Anti-citrulline Antibodies in Rheumatoid Arthritis
… to distinguish self and non-self. Rheumatoid Arthritis (RA) is a systemic autoimmune disease that leads to joint destruction and affects more than 1.5 million adults (Centre for Disease Control). Auto-antibodies against citrullinated proteins (ACPA) are present in approximately 60-75% of RA …
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Potassium channels for high-frequency action potential generation in GABAergic interneurons of Rat Hippocampus
… under ideal voltage-clamp conditions, I started to examine the functional properties of Kv channels expressed in orien-alveus (OA) interneurons in the hippocampal CA1 region, a major class of dendritic inhibitory interneuron. The main results are as follows. First, the macroscopic K+ current …
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Development of microanalysis tools for characterization of the humoral response to infections diseases
… produced by a subset of lymphocytes (B cells) in the immune system for protection against pathogenic species. These homodimers of heterodimers form highly specific interactions with their cognate antigens and hence have become very important for the development of prophylactic or …
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MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION
Although the role of B-cells in autoimmunity is not completely understood, their importance in the pathogenesis of autoimmune diseases has been more appreciated in the past few years. It is now well known that they have roles in addition to (auto) antibody production and are involved by different …
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Untersuchung der Entwicklung der T-Zell-Rezeptor assoziierten Signalleitung im Thymus auf Einzelzellniveau
… hingegen sind vom CD3-Komplex kontrolliert. Die Umstellung von Zytokin- zu CD3-Kontrolle in der Thymozyten Entwicklung findet in der DN3 (DN25+CD44-) Population statt, in der die TZRß-Genumlagerung abgelaufen ist und TZRß-Polypeptidkette exprimiert wurde. Es wurde gezeigt, dass die …
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The Physiological Role of Serotonergic Transmission in Adult Rat Taste Buds
… of taste signals from taste receptor cells (TRCs) to the gustatory afferent nerves, but the surprising discovery that this transmission is actually purinergic has left the actual role of serotonin in the taste bud enigmatic. Across mammalian species, 5-HT is highly conserved in type …