Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"simvastatin"”.
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Novel Effects of Simvastatin on Uterine Fibroids
… of this study was to examine the effects of simvastatin on uterine fibroid, both in vitro and using an animal model. For the in vitro studies, we used primary and immortalized human fibroid cells. For the in vivo studies, we used immunodeficient mice supplemented with estrogen/progesterone …
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Fracture healing in osteopenic bone and the influence of simvastatin
Despite recent improvements in the ability to prevent osteoporotic fracture a vast number of mainly elderly patients continue to sustain fractures resulting in significant morbidity and a huge demand on health care services. Current knowledge of the process of fracture healing in osteoporotic bone …
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Voltametrické stanovení léčiva simvastatin na uhlíkové pastové elektrodě a stříbrné pevné amalgamové elektrodě
Tato diplomová práce se zabývala stanovením simvastatinu metodou cyklické voltametrie (CV), diferenční pulzní voltametrie (DPV) a DC voltametrie s využitím uhlíkové pastové elektrody. Byly nalezeny optimální podmínky pro stanovení simvastatinu v BR pufru a za těchto podmínek byly naměřeny …
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Acyltransferase LovD as a Simvastatin Synthase: Mutational Deconvolution, Design, Substrate Scope and Immobilization
… improved production of the anti-cholesterol drug simvastatin from monacolinic acid J, is performed. First, an analysis of the features affecting the catalytic activity of the enzyme throughout the different rounds of directed evolution (competition between thioesterase, acyltransferase and …
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An investigation involving a comparison between the hydrolytic degradation of lovastatin and simvastatin using HPLC
Lovastatin (LV) and Simvastatin (SV) are known by their common general name of Statins. They are hypolipedemic drugs used for the treatment of hypercholesterolemia. Both statins are administrated as prodrugs that require metabolic activation to form the active acid forms, namely lovastatin hydroxy …
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Interaction of exercise and simvastatin on myocardial ischemia-reperfusion (I/R) injury and post-ischemic cardiac function
Simvastatin is one of the statins, which are a class of drugs originally developed to fight cardiovascular disease by lowering cholesterol. However, it is now clear that they have effects independent of cholesterol. For example, statin therapy, like exercise, induces adaptations within the heart …
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Simvastatin Does Not Sensitize Ibc3 Her2+ Inflammatory Breast Cancer Brain Metastases to Whole Brain Irradiation In An Immunocompromised Mouse Model
… [23]. Our lab has previously demonstrated that simvastatin radiosensitizes IBC cells in vitro [23], and brain metastases have strong expression of cholesterol-regulation genes compared to lung metastases <em>in vivo</em> [unpublished]. Delaying whole-brain irradiation (WBI) beyond 21 days is …
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Evaluation of the novel P particle vaccine candidate against human norovirus using the gnotobiotic pig challenge model
… than VLPs. I also evaluated the effects of simvastatin, a cholesterol-reducing drug that increases NoV infectivity, on P particle vaccine efficacy. Simvastatin abolished P particle-induced protection and significantly increased diarrhea severity. Simvastatin reduced total numbers of duodenal …
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IN VITRO EFFECT OF STATINS ON STREPTOCOCCUS MUTANS, STREPTOCOCCUS SANGUIS, AND STREPTOCOCCUS SALVARIUS
… concentration (MIC) by broth dilution assays. Simvastatin, pravastatin atorvastatin, and rousuvastatin were used in this study. The minimum inhibitory concentration was considered to be the lowest concentration of statin that prevented bacterial growth, i.e. a clear test tube. Experiments were …
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Statin-induced muscle mitochondrial toxicity
… published 8-week clinical trial of high-dose simvastatin or atorvastatin versus placebo. Forty-eight hypercholesterolemic subjects were randomly assigned to receive placebo (N=16), high dose atorvastatin 40mg/day (N=16), or high dose simvastatin 80mg/day (N=16) for 8 weeks. Muscle mtDNA …
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Effect of Rat Strain Stereotactic Coordinates on Infarct Volume
… of the pharmaceuticals Fluoxetine (SSRI), Simvastatin (statin), and ascorbic acid (Vitamin C). 51 adult rat subjects (10-12 months of age; 44 Sprague Dawley, 7 Long Evans) were given a combination of the drugs for 31 days. Drugs were given through voluntary oral administration via sugar …
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Analysis of patient drug usage trends in the POYC scheme
… most commonly used drugs among POYC patients are simvastatin (74), amlodipine (62), aspirin (56), perindopril (56), valsartan (53), metformin (43), omeprazole (43), atorvastatin (34), bendroflumethiazide (32), and salbutamol (30). There has been an increase in the usage for 8 out of 10 drugs. The …
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Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections
… four approved drugs (auranofin, ebselen, simvastatin and celecoxib) that exhibited potent antimicrobial activity against multidrug-resistant bacterial and fungal pathogens. Notably, auranofin, an FDA-approved anti-rheumatic drug possessed excellent antibacterial activity against <em>S. …
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Theranostic nanoparticles for the management of inflammatory diseases and conditions
… in plaque development and progression. First, simvastatin-loaded nanoparticles were designed and optimized. The particles consisted of a biodegradable polymer core and a lipid shell. Using bulk nanoprecipitation methods, as well as microfluidic devices, the physical characteristics of the …
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The significance of OATP and CYP450 in statin-flavonoid interactions
… the flavonoids quercetin and biochanin A on simvastatin toxicity in HepG2 cultures” built off the discussion in chapter 1 and tested the co-administration of the flavonoid’s quercetin and biochanin A with simvastatin in a hepatic carcinoma cell line (HepG2). This study investigated if these …
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Endotype Discovery in Acute Respiratory Distress Syndrome
… (MOSAIC), and a randomised controlled trial of simvastatin in ARDS (HARP-2). A combination of automated clustering methods and network analysis tools have been used to integrate blood biomarkers and gene expression (transcriptomic) data to define distinct endotypes of ARDS. Three endotypes of …
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The Role of Insig-Mediated Cholesterol Homeostasis in Mouse Hair Development
… topical treatment of these mutant mice with simvastatin, an inhibitor of cholesterol biosynthesis, can reduce these sterol intermediates and completely correct the skin defects and alopecia. Further studies of epidermal-specific, Insig-double knockout mice showed that they had a dramatic …
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Investigation of Psychotropic Drugs for the Treatment of Glioblastoma
… psychotropic drugs were used in combination with simvastatin. A rat model of glioblastoma following implantation of isogenic luciferase-tagged F98 cells was used to assess the in vivo potential of the drugs and indicated that treatment with olanzapine extended the life-span of the rats beyond that …
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Autocrine prolactin signaling in breast cancer cells leads to metabolic changes and therapeutic opportunities for anti-tumour and anti-bone metastatic treatment
… cancer-associated bone metastasis. The role of simvastatin in impairing the progression of cancer has also been reported. In this thesis, I characterized cells that were selected for their ability to grow in the bone of immunodeficient mice and subsequently engineered to secrete human PRL …
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Statins Regulate IL-1β - Induced RANKL and OPG Production by Human Gingival Fibroblasts
… were preincubated with atorvastatin or simvastatin for 24 hours in serum-free medium, and then incubated without a stimulus or with IL-1β for 6 days. OPG or RANKL in culture supernatants was measured by specific ELISA. Data were analyzed using ANOVA and Scheffe’s F procedure for post hoc …
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