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Showing 1 to 12 of 12 for “"simulated microgravity"”.
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Hormones, Simulated Microgravity and Hypergravity affect Bone and other Physiological Systems in Zebrafish Larvae
… Vitamin D3), exposure to three different microgravity simulation devices (Clinostat, Random Positioning Machine and Rotating Wall Vessel) and finally exposure to hypergravity and "relative microgravity" in the Large Diameter Centrifuge. By combining morphometric tools with an objective …
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The gravity loading countermeasure skinsuit : a passive countermeasure garment for preventing musculoskeletal deconditioning during long-duration spaceflight
… bodyweight-like loading to the subjects in simulated microgravity, and in some cases provided higher loads to the muscles and joints than those seen during unsuited movements in Earth gravity. Prototype suits were constructed that provided 76-84% bodyweight loading to the subjects. During …
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… explores the effects of mechanical unloading (simulated microgravity) on key adipocyte functions and actin cytoskeletal remodeling. This study demonstrated that mechanical unloading enhances adipocyte maturation via increased lipogenesis and lipolysis and cortical actin remodeling, which …
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Investigation on gravity sensing in garden cress seedlings /
… of the gravitational force was changed from microgravity (real in space or simulated by horizontal clinostat) to 1-g (simulated by centrifugation in space or natural Earth's gravity) and its action direction was changed at 90° or 180° inversion with respect to the longitudinal axis of the …
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Principal component based system identification and its application to the study of cardiovascular regulation
… topic in the field of space medicine: effects of simulated microgravity on cardiac autonomic control and orthostatic intolerance (OI). Experimental data from a prolonged bed rest study (simulation of microgravity condition) are analyzed and the conclusions are: 1) prolonged bed rest may impair …
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The role of osteocytes in disuse and microgravity-induces bone loss
… to investigate their role in disuse and microgravity-induced bone loss. Specifically, we generated and characterized a novel osteocytic cell line that recapitulates the response to hormonal and mechanical stimuli of osteocytes in vivo. This novel cell line provided the first evidence of a …
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MICROGRAVITY-INDUCED ALTERATIONS IN THE BRAIN-TO-BONE AXIS: IMPLICATIONS FOR BONE LOSS AND COUNTERMEASURE DEVELOPMENT IN LONG-TERM SPACEFLIGHT.
… is insufficient for more than six months in microgravity. Thus, it is paramount for the first astronauts landing on Mars to be able to explore the Red Planet's surface upon arrival. This limitation is critical, as astronauts landing on Mars must be capable of immediate surface exploration and …
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The impact of microgravity conditions on human gut microbiome
… unique environmental challenges, particularly microgravity, which can significantly alter the composition and functionality of the gut microbiome, with potential consequences for astronaut health. Despite increasing interest in space microbiology, the precise effects of microgravity on …
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Lipid Signaling Under Microgravity Conditions
… of the Space environment, which include microgravity, altered nutrition, increased radiation exposure, confinement, and other stressors. In this context, a substantial body of literature has documented that the functional integrity of multiple tissues is compromised during Space missions. …
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INHIBITED MINERALIZATION IN OSTEOBLASTS CULTURED UNDER VARIED SIMULATED PARTIAL GRAVITY CONDITIONS AND THE USE OF PHYTONUTRIENTS FOR MITIGATING THE EFFECTS OF REDUCED GRAVITY
… differences between partial gravity and microgravity, and in the unmet need to identify countermeasures to both. A hypothesis to be tested is that reduced gravity impairs a variety of osteogenic cell functions, such as proliferation and differentiation, and that these inhibitory effects …
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Validation of a Two-Dimensional Clinostat Design to Provide Functional Weightlessness to Custom Gas Exchange Vessels
<p>Understanding the impacts of microgravity on bacteria is vital for successful long duration space missions. In this environment, bacteria have been shown to become more virulent, more resistant to antibiotics and form more biofilms. To learn more about these phenomena, many experiments must be …