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Showing 1 to 4 of 4 for “"simocyclinone"”.
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A fragment based approach to the development of novel antibacterial agents inspired by the natural product simocyclinone D8
The novel mechanism of simocyclinone D8 (SD8) against DNA gyrase has inspired medicinal chemists for over a decade. The search for antibiotics with new mechanisms of action has never been more important with ever increasing prevalence of resistance. This project had three objectives. Firstly to …
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Investigations of Novel Mechanisms of Action for Anti-Bacterial and Anti-Cancer Agent Development
… of this work concerns with the natural product Simocyclinone D8 (SD8). Simocyclinone D8 is an angucyclinone antibiotic that inhibits DNA gyrase with a novel mechanism of action that has been termed competitive inhibition. Simocyclinone D8 was found to inhibit the growth of both Gram-(+ve) and …
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Polyenantibiotika aus Streptomyceten : molekularbiologische Untersuchungen zur Biosynthese von Simocyclinon und alpha-Lipomycin
… neben Simocyclinon D8 eine Anzahl weiterer Simocyclinone produziert. Die verschiedenen Simocyclinone unterscheiden sich zum einen durch ganze Strukturelemente voneinander und zum anderen durch Modifizierungen, wie die Acetylierung der D-Olivose an Position C-4 und die Halogenierung des …