Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"simian immunodeficiency virus"”.
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Construction of a Simian Immunodeficiency Virus Vaccine from Cynomolgus Macaque Cytomegalovirus
… 30 million globally. Vaccines based on herpesvirus vectors, in particular cytomegalovirus, generate unique, robust immune responses that may overcome many of the typical obstacles to an effective preventative HIV vaccine. Recent studies using a cytomegalovirus based vaccine in the rhesus …
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Study of the Immune Correlates of Protection in Rhesus Macaques Vaccinated against Simian Immunodeficiency Virus
After more than thirty years since the Human Immunodeficiency Virus (HIV) was identified, only the RV144 phase III vaccine clinical trial provided evidence of protection from virus infection, with 31.2% of the patients protected at three years since the end of the immunisation phase. Statistical …
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Early Events Following Oral Transmission of Simian Immunodeficiency Virus: From Viral Entry to Host Immune Response
… following oral inoculation of macaques with Simian Immunodeficiency Virus (SIV) and correlate these findings with disease progression. To assess the virologic events involving viral entry and spread, macaques were orally inoculated with SIV and necropsied at early times post-infection (days 1 …
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African Green Monkeys Evolved Towards Rapid Development of a gp120-focused B Cell Response During Acute Simian Immunodeficiency Virus Infection.
North Carolina State University Theses Immunology.
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Genomic signatures of recent selection at HIV host susceptibility genes in a Central African human population
Multiple independent transfers of simian immunodeficiency virus (SIV) strains from chimpanzees to human populations produced the current HIV-1 pandemic. We hypothesized that Central African human populations may have been exposed to SIV prior to the current pandemic, and that previous local …
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Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following Discontinuation of ART
… of ART in people living with Human Immunodeficiency Virus-1 remain largely unknown. We investigated detailed reservoir characteristics and viral rebound dynamics in 18 Simian Immunodeficiency Virus-infected rhesus macaques treated with antiretroviral therapy for 70 weeks and then …
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The impact of sexually transmitted infections and inflammation in the female genital tract and blood on susceptibility to HIV-1 infection and disease progression
… for immune cell recruitment and establishment of simian immunodeficiency virus (SIV) infection following vaginal inoculation. The aims of this study were to evaluate the relationships between inflammation in the female genital tract and (i) susceptibility to HIV-1 infection and (ii) subsequent …
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Novel strategies for characterizing T Cell responses in SIV-infected rhesus monkeys
Human Immunodeficiency Virus (HIV) is the cause of Acquired Immune Deficiency Syndrome (AIDS) and has killed over 25 million people since the disease was first recognized in 1981. As of 2007, 33 million people globally are infected with HIV and this number is growing. HIV infects and depletes CD4+ …
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Impact of Thymectomy on the Peripheral T Cell Pool in the Context of SIV Infection
… of particular interest in the context of human immunodeficiency virus (HIV)-1 infection, in which the progressive loss of CD4+ T cells leads to immunodeficiency and opportunistic infection. CD4+ T cell loss is thought to result from direct and indirect killing of CD4 cells in the periphery as …
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Mucosal Immunopathogenesis of Feline Immunodeficiency Virus (FIV)
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) have profound effects on the structure, function and leukocyte populations of the gastrointestinal tract. Intestinal tract changes have been identified in SIV-infected macaques as early as 1-2 weeks following experimental …
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Virus tropism and neutralization response in SIV infection
Simian immunodeficiency virus (SIV) infections in macaques are commonly used as models to study the pathogenesis of human immunodeficiency virus (HIV). Both SIV and HIV normally use the CD4 receptor and an additional coreceptor for cell entry. The most common coreceptors used by HIV are CCR5 and …
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Roles of Cyclic GMP-AMP Synthase in Immune Defense Against Retroviruses and Autoimmunity
… essential roles in immune defense against retroviruses as well as in autoimmune diseases caused by self-DNA. HIV infection abrogates adaptive immunity by the depletion of CD4 T cells. However, innate immune defense mechanisms against HIV are largely unknown. We show that pseudotyped HIV can …
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Functional Characterization of the HIV-1 NEF Acidic Cluster
The human immunodeficiency virus (HIV) infects over 39.5 million people worldwide (UNAIDS/WHO 2006 Epidemic Report). Unfortunately, various socioeconomic factors have hastened the epidemic spread of HIV in Africa and in third world countries where many individuals do not have access to appropriate …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
The predominant route of human immunodeficiency virus type 1 (HIV-1) transmission is infection across the vaginal mucosa. Epithelial cells, which form the primary barrier of protection against pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV …
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Kinetik von NK-Zellen und gamma-delta-T-Zellen nach Infektion von Rhesusaffen mit Immundefizienzviren
Human immunodeficiency virus (HIV) infection and the caused acquired immunodeficiency syndrome (AIDS) developed over the last 25 years to a pandemic. In 2006 more than 39 Million people were HIV positive. Based on the high concordance with the human and viral system, rhesus macaques infected with …
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Assessing the Efficacy of Interleukin-7 as an Immunotherapeutic in the SIV+ Rhesus Macaque Model
Human Immunodeficiency Virus (HIV) infection is known for depleting ‘helper’ CD4+ T cells. Highly active antiretroviral therapy (HAART) reduces viremia and increases CD4+ levels, however, 5-20% of patients fail to reconstitute CD4+ T cell levels despite viral suppression. Interluekin-7 (IL-7), a …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… as one of the co-receptors involved in human and simian immunodeficiency virus (HIV-1 and SIV)-infection of CD4+ immune cells. We have described the genomic organization of cmklr1 in mouse and analysed the regulatory mechanism behind the corresponding receptor expression. Two transcripts of mouse …
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On single-cell immune dynamics of chronic HIV infection and treatment in rhesus macaque models
Human Immunodeficiency Virus (HIV) continues to be an overwhelming challenge in both global health and immunology. With no cure available, 30 million people worldwide rely on antiretroviral therapy (ART) to prevent transmission and disease progression. However, individuals on ART are at elevated …
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The Dynamic Interplay Between Lentiviral Vif and Human APOBEC3 Proteins
… that are largely species specific. However, a simian immunodeficiency virus (SIV) Vif exhibits cross-species degradation capability against multiple human A3 enzymes. We used mutagenesis coupled with functional assays to determine the residues involved in the interaction between the SIV Vif and …
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