Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"silent mutations"”.
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Mechanism of Pathogenesis and Replication of an Avian Strain of the Hepatitis E Virus in a Chicken Model
… the prototype pathogenic strain. Numerous non-silent mutations were observed in ORF1, the region coding for the nonstructural proteins. Six unique non-silent mutations were identified in the capsid-encoding ORF2 region and the ORF3 had four non-silent mutations. Phylogenetic analysis based on …
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Prediction, validation and functional analysis of miRNA targets in Arabidopsis thaliana
… and MRG1. Overexpression of MYB101 containing silent mutations in the miR159 binding site (MYB101mutBS) resulted in accumulation of MYB101 in tissues where the transcript is normally absent. The overexpression of wild-type MYB101 did not show this effect. Adult plants overexpressing MYB101mutBS …
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Renal dopamine and salt-retaining states
… in intronic regions or, when exonic, generated silent mutations, supporting the enzyme kinetic data. The expression of ASA was investigated to determine the basis of the increased activity observed in diabetes mellitus. Although a validated comparative RT-PCR assay was developed for …
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Translation rate is genetically encoded and influences protein folding
The degeneracy of the genetic code allows most amino acids to be encoded by multiple codons. The distribution of these so-called synonymous codons among protein coding sequences is not random and multiple theories have arisen to explain the biological significance of such non-uniform codon …
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REDOX PROTEOMICS, THIOL HOMEOSTASIS AND NEUROPHYSIOLOGICAL CORRELATIONS IN AGING AND NEURODEGENERATION
… as proteins, RNAs and DNA. Chaperone-buffered silent mutations may be activated during the aging process and lead to the phenotypic exposure of previously hidden features and contribute to the onset of multigenic diseases, such as age-related disorders, atherosclerosis and cancer. Recent …
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MOLECULAR GENETICS OF HAEMOPHILIA A IN SINGAPORE
… region of factor VIII gene (9 kb) for point mutations, small deletions and insertions. Ten out of 16 genetic defects detected were novel and this included two missense mutations, five frameshift mutations, two silent mutations and one polymorphism. Pedigree analysis for 1 out of 9 families …
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Impatto di rifaximina sul microbiota intestinale: selezione di bifidobatteri antibiotico resistenti
… selection of resistant mutants. Since point mutations in rpoB have been indicated as representing the principal factor determining rifampicin resistance in E. coli and M. tuberculosis, whether a similar mechanism also occurs in Bifidobacterium was verified. The analysis of a 129 bp rpoB core …