Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 977 for “"silencing"”.
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Silencing ITGB3 in Astrocytes
… injury. Based on the 48 hour time point, a gene silencing technique was used to successfully lower ITGB3 levels without compromising astrocyte viability. After blast exposure, astrocytes with silenced ITGB3 protein showed lower levels of a structural protein called vinculin. These results were …
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The Role of Endogenous Arabidopsis Proteins In Rna Silencing and Hc-Pro-Mediated Suppression of Silencing
<p> RNA silencing is a sequence-specific RNA degradation pathway that acts as an antiviral defense pathway. Viruses have evolved suppressors of RNA silencing, including the potyviral protein Helper Component-Proteinase (HC-Pro). Our focus on evaluating the mechanism of HC-Pro function has led us to …
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Visualizing the Structural Basis of Genome Silencing
Eukaryotic genomes must be folded and compacted to fit within the restricted volume of the nucleus. This folding, and the subsequent organization of the genome, reflects both the transcription profile of the cell and of the specific cell type. A dispersed, mesh-like chromatin configuration, for …
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Does Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?
… for skeletal muscle adaptations. How histone silencing marks regulate skeletal muscle adaptations through angiogenesis in response to training is yet to be explored in depth. My thesis aims to research how histone silencing marks regulate skeletal muscle angiogenesis through MDM2 and EZH2, in …
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Molecular mechanism of KAP1-dependent transcriptional silencing
… KAP1 induces the assembly of an epigenetic silencing complex, with chromatin remodeling activities that repress transcription of the targeted retrotransposon and adjacent genes. To understand the molecular basis of KAP1-dependent transcriptional regulation I determined the crystal structure …
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Silencing and recombination in yeast ribosomal DNA
… results showing the dynamics of rDNA silencing and recombination in laboratory strains.
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Epigenetic silencing of gene expression in paediatric astrocytoma
… understanding of the effect of epigenetic silencing on paediatric HGA. This investigation also demonstrated the use of epigenetic drug, 5-aza-dC to reverse the gene silencing for the potential treatment of paediatric HGA.
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Mechanisms of piRNA-guided co-transcriptional gene silencing
… depends on the Panx-induced co-transcriptional silencing (PICTS) complex, which contains Panx, Nxf2 and Nxt1. PICTS operates at the interface between piRNA-guided Piwi and heterochromatin effectors. While the N-terminal region of Panx is known to deliver the transcriptional silencing signal, the …
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Silencing the host : the role of intronic microRNAs
Fifteen years ago lin-4 was reported to be the first endogenous small non-coding, but interfering RNA structure involved in developmental timing in C. elegans. First thought not, or only rarely, to occur in mammals, microRNAs are now among the major players in up-to-date genomic research. The …
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IMPACT OF ACLY GENE SILENCING ON HEPATIC LIPID METABOLISM
Introduzione e scopo: ATP citrato liasi (ACLY) è un enzima chiave del metabolismo lipidico, responsabile della conversione di acetil-CoA citosolico a partire dal citrato mitocondriale. L’acetil-CoA generato costituisce un precursore fondamentale sia per la de novo sintesi degli acidi grassi, …
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Depression and self -silencing in lesbian and heterosexual women
… but otherwise excluded) using Jack's Silencing the Self Scale, the Beck Depression Inventory, and a demographic questionnaire. Lesbians were also asked to complete Cass' Stage Allocation Measure. An additional 11 subjects failed to complete the BDI and so were excluded from all …
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Sequence-specific gene silencing by transitive signals in plants
… field that aims at unraveling the process of RNA silencing, in particular of transitive silencing. In the first, application-oriented part of the thesis, we examined the potential of transitive silencing as a tool for functional genomics, and in the second, more fundamental part, we focused on …
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Silencing violence in the family: Making the victim the problem
The title of my research, Silencing Violence in the Family: Making the Victim the Problem, consists of two parts: an autobiography which explores the nature and dynamics of violence against children within an Australian home and the ways in which it is silenced within the family, schools and …
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The development of gene silencing strategies for plant parasitic nematodes
… the utility of siRNAs as triggers for gene silencing in PPNs; identify the first lethal siRNAs in any parasitic nematode; associate development processes in nematode parasites with non-coding RNAs; include the development of bioassays to delineate the phenotypic impacts of RNAi; identify a …
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Burn injury and self-silencing: a study of women's narratives
… of distress, the women engaged in “self-silencing,” of which three forms are outlined. The self-silencing functioned to help the women resist the cultural devaluing associated with “disfigurement” and more personally, to maintain close relationships. As self-silencing has been linked to …
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Gene discovery in Catharanthus roseus using virus induced gene silencing
… thesis presents the use of Virus Induced Gene Silencing (VIGS) for the discovery of enzymes and transporters involved in monoterpene indole alkaloid (MIA) metabolism in the medicinal plant Catharanthus roseus. C. roseus is the source of a number of MIAs that are used as chemotherapeutic agents …
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piRNA-dependent transcriptional gene silencing during Drosophila oogenesis and embryogenesis
… is recruited and induces transcriptional gene silencing (TGS) by connecting to the general chromatin silencing machinery of the cell resulting in changes of the epigenetic chromatin state, thus shutting down transcription. However, whether Panx acts on its own or if other proteins are involved …
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