Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"sildenafil"”.
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Quality of Life and Sexual Functioning of Men Treated with Sildenafil Citrate (Viagra)
… the use of the oral pharmacotherapeutic agent, sildenafil citrate (Viagra). Thirty-two male veterans from an upper-midwestern area completed the Quality of Life Index (QLI), the Centers for Marital and Sexual Health-Sexual Functioning Questionnaire (SFQ), and an author generated demographic …
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Type-5 Phosphodiesterase Inhibition in the Prevention of Doxorubicin Cardiomyopathy
… investigations are designed to determine if sildenafil, a phosphodiesterase-5 inhibitor and known mitochondrial KATP channel opener, would protect against chronic doxorubicin cardiomyopathy both in vivo and in vitro.Male ICR mice were randomized to 1 of 4 treatments: saline, sildenafil (0.7 …
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A Description of the Use of Sildenafil in the Paediatric Intensive Care Unit at Red Cross War Memorial Children's Hospital
… pulmonary hypertension (PH) are largely unknown. Sildenafil is the only available oral treatment for PH in South Africa (SA) and is widely used, mostly off-label, despite little evidence for safety or efficacy. Objectives. To describe the use of sildenafil in the Paediatric Intensive Care Unit …
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Long-term cardioprotection with phosphodiesterase-5 inhibition against ischemia-reperfusion injury: Role of nitric oxide.
… potent phosphodiesterase-5 (PDE-5) inhibitor, sildenafil citrate, induces a powerful cardioprotective effect against ischemia-reperfusion (I/R) injury in rabbit and mouse hearts. However, the effect of this drug in inducing long-term protection against I/R injury remains unknown. The goal of …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… thereby decreasing its tissue concentration. Sildenafil is a potent selective inhibitor of PDE-5 and therefore allows the accumulation of cGMP in several tissues shown to express PDE-5, including pulmonary and coronary arteries. We initially hypothesized that vasodilation induced by sildenafil …
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The use of inhaled nitric oxide to treat persistent pulmonary hypertension of the newborn in a tertiary public hospital in South Africa from 2010-2014: morbidity, mortality and cost
… have access to iNO, ECMO is not available. Oral sildenafil can be effective in settings where iNO is not available, but its effect on outcome and cost of treatment in this setting have not been described. The literature review in the first part of this thesis describes five studies reporting …
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Complementary and alternate medicines: a forensic analysis of the potential adulteration of over-the-counter anorectics and "lifestyle" medicines in South Africa
… anorectics and a schedule 6 prescription drug, sildenafil, found in natural erectile dysfunction preparations. Methods: Initially, 26 exhibits (18 erectile dysfunction medicines and 8 anorectics) were screened for active pharmaceutical ingredients using high performance liquid chromatography …
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Influences of first-line oral monotherapy on outcomes in Pulmonary Arterial Hypertension in association with Connective Tissue Disease.
… of first-line monotherapy with bosentan or sildenafil and the introduction of prescribing guidelines on outcomes in PAH-CTD. Methods Following a retrospective analysis of consecutive, incident, treatment-naive PAH-CTD cases identified by the ASPIRE registry, influences on outcome measures …
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PHOSPHODIESTERASE-5 INHIBITION: A NOVEL STRATEGY TO IMPROVE STEM CELL THERAPY IN THE HEART
… the hypothesis that inhibition of PDE-5 with sildenafil (Viagra®) or selective knockdown with a silencing vector in adipose derived stem cells (ASCs) would improve their survival after ischemia/reoxygenation in vitro and enhance cardiac function following myocardial implantation in vivo. ASCs …
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Caracterización de la hipertensión pulmonar persistente en recién nacidos con asfixia tratados con hipotermia, Bogotá (2019–2023)
… Asimismo, el uso de óxido nítrico, surfactante, sildenafil, VAFO y múltiples vasopresores se concentró en este subgrupo. La mortalidad fue del 7,6% en la cohorte global y del 23,4% en pacientes con HPPRN severa. Conclusión: La HPPRN fue una complicación frecuente en esta cohorte. Sus …
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Medicalization as a Trojan Horse: Changes in Erectile Enhancement Advertising
… (2007). With the advent and success of Viagra (Sildenafil) in 1998, a wave of products emerged treating erectile dysfunction and not long after followed the expansion of the market for erectile enhancement. Although several studies have been done of erectile dysfunction, there has been less …
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Studies in Synthesis and Organocatalysis: (i) The Design and Synthesis of Novel Electron Deficient Dienes and their Application in the First Enamine Activated Organocatalytic 1,6-Conjugate Addition. (ii) The Development of a New Organocatalytic Methodology through the Combination of DNA-Based Catalysis and Organocatalysis
… addition methodology to the synthesis of Sildenafil analogues. Several steps of this challenging synthesis were completed. The step involving the oxidation of a homo-allylic alcohol remains to be solved. Interestingly a DMSO-based oxidation generated a sulfur ylide in high yield (90%), a …
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MOLECULAR AND FUNCTIONAL CHARACTERISATION OF THE ROLE OF HYDROGEN SULPHIDE IN SEXUAL MEDICINE
… of high NO (observed in animals treated with sildenafil), normal H2S level and production were observed, while under condition of low NO (observed in animals treated with NO synthase inhibitor L-NAME), high H2S level was observed. Thus, shortage of NO can trigger the production of H2S, which …
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The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… treprostinil, the phosphodiesterase-5 inhibitor sildenafil and the endothelin-1 antagonist bosentan were negative. Bosentan, however, inhibited the hypoxic PAF-PASMC interaction, suggesting endothelin-1 release by hypoxic PAFs, with proproliferative effects on PASMCs. The results reported in this …
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Sexual-Enhancement Drug Use in College-Age Men
Viagra and other erectile-dysfunction (ED) medications are typically associated with older men. There is thus little research on their use in college-age men. The purpose of the present study was to explore the use of sexual-enhancement drugs (SEDs) in college men and to compare the men who had …
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Identification of a ciliary defect associated with pulmonary nontuberculous mycobacterial disease
Over the past several decades, the rate of pulmonary nontuberculous my- cobacterial (PNTM) disease has been increasing. PNTM patients gener- ally consist of lean and tall women presenting with symptoms in the sixth decade of life. They have a de nitive morphophenotype, but no consistent …