Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"signalosome"”.
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AKAP12 Signalosome Regulates Cardiac β2-Adrenergic Receptor Signaling
… (a general determinant of HF). The ability of signalosomes (molecular signaling complexes) to compartmentalize several cellular pathways has been recently established. One example of these signalosomes is a family of scaffolding proteins known as, A Kinase Anchoring Proteins (AKAPs). In …
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Designing Compounds that Probe the Phosphatidylinositol 3-Kinase Signalosome
… with membrane-binding and formation of the PI3K signalosome.
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Role of the COP9 Signalosome In Defense Responses In tomato
<p>The COP9 Signalosome (CSN) is an evolutionarily conserved multi-protein complex that regulates proteasome-mediated proteolysis. While the CSN has been shown to function in various growth and developmental processes, the involvement of the CSN in the regulation of defense responses is largely …
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Amino Acid Biosynthesis and the COP9 Signalosome in Aspergillus nidulans
Der filamentoese Pilz Aspergillus nidulans ist ein eukaryontischer Modellorganismus mit vielseitigem Metabolismus und Entwicklungspotential. Diese Arbeit befasst sich mit der Auswirkung von veränderten Enzymaktivitäten innerhalb zweier regulatorischer Netzwerke auf den pilzlichen Organismus. Das …
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Cop 9 Signalosome Subunit 6 Stabilizes Cop1, A Novel E3 Ubiquitin Ligase For 14-3-3Σ
… We show for the first time that COP9 signalosome subunit 6 (CSN6) associates with COP1 and is involved in 14-3-3σ ubiquitin-mediated degradation. Mechanistic studies show that CSN6 expression leads to stabilization of COP1 through reducing COP1 self-ubiquitination and decelerating …
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COP9 signalosome subunit knockdown in K562 provides novel insight into the function and potential regulation of the CSN
… is mediated by the eight subunit COP9 signalosome (CSN; CSN1-8). Cullin deneddylation by the CSN has been demonstrated to prevent the autocatalytic degradation of the substrate recognition subunit (SRS) of CRLs. The CSN has also been shown to associate with deubiquitinase and kinase …
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… murine heart. (6) GPR30 constitutively form a signalosome with Membrane associated guanylate kinase proteins (MAGUKs) and A Kinase Anchoring Protein 5 (AKAP5) through its C-terminal PDZ-motif. PKA-RII, which directly binds to AKAP5, is responsible for the attenuation of cAMP in response to …
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The role of FOXK transcription factors in Wnt signal transduction
… nuclear multiprotein complexes; the degradasome, signalosome and enhanceosome. The latter is tethered to enhancers by T-cell transcription factors (TCF), and core components include the chromatin reader Pygopus as well as the transcriptional repressor Groucho/TLE3. While much is known about the …
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Investigation of the effect of a probiotic-supplemented diet on the haemocyte proteome of the abalone Haliotis midae
… diet were identified as COP9 signalosome subunit 4, phosphorylase, T-complex protein 1 subunit gamma, V-type proton ATPase subunit B, Rab 1 and Ra-related protein Rab 1A. Differential expression of COP9 signalosome subunit 4 (up-regulated) and Ras-related protein Rab 1A …
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Elucidating the molecular mechanisms of p110δ activation in T cell antigen receptor signalling
… that may regulate p110δ activity at the TCR signalosome. This study has also developed a CRISPR/Cas9-mediated gene editing approach to disrupt targets of interest in primary murine activated T cells via ribonucleoprotein (RNP) nucleofection. This system was used to investigate the roles of …
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ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
… stimulation where it interacts with the immune signalosome. Using complementary biochemical and cellular assays, I demonstrate ADAP1 directly stimulates the GTPase activity of KRAS to amplify CD4+ T cell signaling through targeted activation of ERK-AP-1 axis. In primary CD4+ T cells which I have …
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Mechanisms of molecular switching in the Wnt signal transduction pathway
… for degradation in the absence of Wnt; the ‘signalosome’, which is assembled by Dishevelled upon Wnt-receptor binding to inactivate the degradasome, thus allowing β-catenin to accumulate; and the ‘enhanceosome’, which captures β-catenin, granting it access to target genes and relieving their …
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The role of BCAP in regulating the TLR signalling pathway
… and activation of PI3K and PLCγ2 to the TLR signalosome. In this study, a robust protocol was developed to phosphorylate BCAP in vitro by BTK, further examining critical post-translational modifications of BCAP. A novel tyrosine phosphorylation site was identified by mass spectrometry, in …
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Neuropathological significance of PLD1 in Alzheimer's disease and behavioral variant frontotemporal dementia
… tau effects, I addressed the premise of PLD1 signalosome in the etiology of a primary tauopathy, bvFTD (behavioral variant Frontotemporal Dementia or Pick’s disease). To establish the scientific premise, I used postmortem brain regions donated by the patients to NeuroBioBank under MTA …
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The Novel Upstream Regulator of Fbxw7
… 1 (COP1), AKT and CSN6 (i.e. the COP9 signalosome 6).</p> <p>COP1 is an E3 ubiquitin ligase targeting important substrates such as, p53, 14-3-3-σ, and c-Jun. I found that COP1 binds to FBXW7 at the binding motif at V200 and P201. Interestingly, binding between COP1 and FBXW7 was …
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… assays revealed that Grb2 is essential for LAT signalosome formation. Surprisingly, after a preliminary proteomics assay it was found that these cells also fail to express THEMIS, making this new cell line a good study model for Grb2 interactions with ligand proteins to regulate intracellular …
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Regulation of inflammatory TLR signalling by the BCAP adaptor
… BCAP then recruits PI3K and PLC-𝛾2 to the TLR signalosome. Although these proteins can facilitate negative regulation of TLRs by endocytosis, the mechanism by which BCAP dampens TLR signalling remains elusive. The first aim of this thesis is to determine the minimal domain requirements and …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… maintaining HSV latency. Activation of β-catenin signalosome expression has also been implicated during HSV latency and following reactivation. GSK3β is a key effector molecule that inter-connects Akt and β-catenin mediated pathways, forming an Akt-GSK3β-β-catenin signaling axis. Analyzing the …
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Model for tooth development in vitro
… revealed a dramatic remodelling of the signalosome in the DPCs. The cells instantly responded to the changed culture conditions and subsequent cell-cell interaction with significantly modulated gene expression regarding cytoskeletal rearrangement. The suppression of RhoA activity was …
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