Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 366 for “"signalling pathway"”.
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
Organisms are constantly threatened by the invasion of viruses and have evolved systems of immune defense to eliminate viruses in the body. Intracellular viral infections are detected primarily by immune recognition of viral nucleic acids. Many intracellular DNA sensors induce the expression of …
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Decoding the structure WWP2 in the TGFβ signalling pathway
… motifs found in the sequences of the Smad signalling proteins that propagate or inhibit the TGFβ pathway, and in so doing, allows WWP2 to regulate its Smad targets. WWP2 has three isoforms that are known to participate in regulation of TGFβ signalling, but, even amongst isoforms of the same …
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The AMPK signalling pathway in cancer and DNA damage
… of the tumour suppressor LKB1, that the AMPK signalling pathway is down-regulated in some tumours, and that diabetics treated with the AMPK-activating drug metformin exhibit a lower incidence of cancer. These results suggest that AMPK may itself be a tumour suppressor, although direct evidence …
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Curation, characterisation and prediction of Drosophila signalling pathway members
Signalling pathways are key to virtually every aspect of the biology of multicellular organisms. Extensive research in Drosophila melanogaster has greatly contributed to the understanding of these pathways, but a central resource distilling the vast literature on the topic has been lacking. At the …
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VHL inhibitors as chemical probes of the hypoxia signalling pathway
… VHL inhibitor as a chemical probe of the hypoxia signalling pathway with great potential to address biological questions regarding the roles and regulation of VHL. The VHL inhibitor is a unique tool due to its on target selectivity and specificity in inducing HIF activity, without affecting …
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Signalling pathway of FBXO7 and its role in hereditary Parkinsonism
… is reasonable hope that dissecting molecular pathways of PD gene products will have more general implications for the pathophysiology of PD associated neurodegeneration and help device new treatment strategies.<br/>Mutations in the FBXO7 gene have recently been shown to cause an autosomal …
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Mechanistic Insights into the Notch signalling pathway through Molecular Condensation
… identity, and cell positional information. A key signalling pathway in interpreting this information is the Notch signalling pathway. It is currently poorly understood how Notch is able to play a titratable role in signal transduction as our current model does not effectively translate how …
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The role of BCAP in regulating the TLR signalling pathway
… a negative regulator in the TLR4 MYD88-dependent signalling pathway. This study utilises biochemical, biophysical and structural biological techniques and focuses on two hypotheses to elucidate the role of BCAP in the TLR signalling pathways. The first hypothesis focuses on the steric inhibition …
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Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV)
… have identified multiple signal transduction pathways that convey the Mstn signal. Mstn has been shown to influence canonical TGF-β, mitogen activated protein kinase (MAPK) and the PI3K/AKT signal transduction cascades. The discovery in our laboratory of a novel splice variant of Mstn (MSV) …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… (MyD88) plays a central role in innate immune signalling by acting as an adaptor protein downstream of most of the Toll-like receptor (TLR) family and all the IL-1 receptor family members. Activation of MyD88 dependent signalling is critical for the immune response during infections, however …
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Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>
… essential role in the fungal cell wall integrity pathway and possesses a unique C-terminal CNH (Citron homology) domain. Using genetic and molecular approaches I characterised the functions of the Rom2 CNH domain in the pathogenic fungus <i>Aspergillus fumigatus</i>. Cell wall analysis including …
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Investigating the Non-globular Proteins of the Canonical Wnt Signalling Pathway
The canonical Wnt pathway is a vitally important signalling pathway that plays an important role in cell proliferation, differentiation and fate decisions in embryonic development and in the maintenance of adult tissues. The twelve Armadillo (ARM) repeat-containing protein beta-catenin acts as the …
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Strategies to Target the Bone Morphogenetic Protein Signalling Pathway in Lung Disease
… or delayed progression of disease, represents a pathway for the delivery of novel style therapies and for the targeted delivery of different of more toxic drugs to the airways in order to increase efficiency of both the delivery mechanism and of the drug utilised. Here we looked at the use of a …
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Characterisation of the Auxin Signalling Pathway in Vitis vinifera L. cv. Shiraz
… a finely tuned transcriptional system. The auxin signalling pathway consists of the transcription factors, auxin response factors (ARFs), the transcriptional repressors, auxin/indole-3-acetic acid (Aux/IAAs), and the transport inhibitor response 1/auxin signalling F-box (TIR1/AFB) proteins that …
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Exploring a Nuclear Insulin Receptor Signalling Pathway in Drosophila Neural Stem Cells
… and NSC biology. In *Drosophila*, insulin signalling is necessary and sufficient for the reactivation of NSCs from quiescence, a conserved state of mitotic dormancy. InR has been observed in the nucleus of a range of cell types *in vitro* for decades, but it is only more recently that the …
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Using a chemical genetics approach to dissect the nitrogen signalling pathway in Arabidopsis
Nitrate is an important nutrient and signalling molecule to plants. As it is taken up and assimilated, reduced forms of N accumulate and the expression of many genes associated with nitrate assimilation are repressed. Little is known about the mechanisms involved in this N repression. This project, …
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A study of the NF-κB signalling pathway in human acute myeloid leukaemia.
… and destructive role in cells. NF-κB protects by signalling for the immune system when cells fall under attack from pathogens. NF-κB signalling becomes a danger to cells when signalling becomes constitutive and can promote excessive inflammation and tumourigenesis. Constitutive NF-κB signalling …
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Defining the mechanisms of specificity in the symbiosis signalling pathway of Medicago truncatula
… of these two symbioses depends upon signalling between the plant host and the microorganism, of which lipochitooligosaccharide (LCO) signals are essential. Perception of symbiotic LCOs induces a signalling pathway which is common to both mycorrhization and nodulation, and oscillations …
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The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation
The WNT pathway is a major developmental pathway that plays an important role in the development of many tumours, including neuroectodermal and bone tumours. Ewing sarcoma (ES) / primitive neuroectodermal tumour (PNET) shows varying degrees of neuroectodermal differentiation and is the second …
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