Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"signalling network"”.
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New signalling network in plant abiotic stress discovered through a genetic approach
… the interactive relationships between different signalling pathways triggered by the stress factors tested, indicating new features on the control of the expression of RCI2A. First, a novel cold-signalling pathway different to the CBF/DREB1-dependent pathway, was proposed to induce the expression …
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
The TAK1 and canonical IKK complexes are the two master protein kinases of the innate immune system that control the production of inflammatory mediators, but the mechanisms by which they are activated in this system are still unclear. In this thesis, I present the research I have carried out to …
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To signal or not to signal: Molecular information processing through the B-cell signalling network
Contains fulltext : 321287.pdf (Publisher’s version ) (Open Access)
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A NOVEL PIPELINE FOR DRUG DISCOVERY IN NEUROPSYCHIATRIC DISORDERS USING HIGH-CONTENT SINGLE-CELL SCREENING OF SIGNALLING NETWORK RESPONSES EX VIVO
… of kinetic ligand responses across cell signalling networks at the single-cell level in distinct PBMC subtypes ex vivo. Using automated sample preparation, fluorescent cellular barcoding and flow cytometry the platform is capable of detecting 21, 840 parallel cell signalling responses in …
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Understanding the mechanisms of cir1 disease resistance in Arabidopsis thaliana
… infections. To gain insight into the defence signalling network and defence responses deployed by plants for resistance to pathogens, the defence-related Arabidopsis thaliana mutant cir1 (constitutively induced resistance 1) was further investigated. It was previously shown that cir1 …
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The involvement of microglial activation in schizophrenia
… alterations in microglial intracellular signalling cascades induced by schizophrenia patient serum relative to control serum. Using automated sample preparation, fluorescent cellular barcoding and flow cytometry, the applied platform is capable of detecting multiple parallel cell …
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IDENTIFICATION OF CDC7 AS A NEW REGULATOR OF T CELL ACTIVATION
… was designed to identify novel mediators of TCR signalling. A library of kinase inhibitors was screened for their effects on suppressing activation in several T cell populations. The screening assay was able to identify inhibitors of canonical kinases of TCR signalling and kinases that were not …
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Analysis of the understudied parts of the phospho-signalome using machine learning methods
… to external stimuli, cells rely on an intricate signalling system. One of the most important and best studied components of this signalling system is the phospho-signalling network. Phosphorylation relays information through adding phosphoryl groups onto substrates such as lipids or proteins, …
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The Integration of Metabolite and Hormone Signalling Drives Seedling Development
… plant biology, acting as structural components, signalling molecules, and sources of energy. As such, the availability of sugars has important implications for plant growth and development. Sugar levels rise and fall as part of a daily cycle, while cues from other environmental stimuli are also …
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Identification of a mitogen-activated protein kinase, p56, which mediates the self-incompatibility response in Papaver rhoeas L.
… transduction pathway that activates a complex network of intracellular events including Ca\(^{2+}\)-dependent phosphorylation of p26, an inorganic pyrophosphatase required for pollen tube growth, depolymerisation of the pollen actin cytoskeleton and ultimately programmed cell-death (PCD). To …
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An investigation into the mechanisms of angiogenesis and breast cancer metastasis
… resulted in increased upregulation of Notch signalling pathway (major regulator of angiogenesis) ligand DLL1 and DLL4. Additionally, we investigated genomic changes that may be involved in the development and progression of breast to brain metastasis (BBM). Whole exome sequencing (WES) of 26 …
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Modelling the endothelial cell response to fluid flow
… (though perhaps not sufficient) component of the signalling network. In some processes cross talk between the GTPases is thought to be important in forming spatially segregated zones of activation, for example in the front and back of migratory cells. This research shows that local signalling in …
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Engineering a synthetic p53-Mdm2 network in budding yeast
… about the mechanisms regulating the p53 signalling network. Indeed, the p53 network is extremely intricate and complex, and from a system biology point of view it can be seen as a series of interconnected negative and positive feedback loops, which can give rise to complex dynamics such …
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The role of ACK in regulating the Vav family proteins
… substrates for ACK and shown their downstream signalling pathways can contribute to cancer progression. However, whether ACK can be used as a therapeutic target in cancer remains a debatable issue. It is likely that the ACK signalling network is yet to be completely elucidated. To understand …
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Global characterization of oncogenic kinase signaling
… the urgent need to better understand the complex signalling network governed by Src and design novel therapeutic strategies. In this thesis, a novel approach integrating mass spectrometry-based quantitative kinome profiling and siRNA-based functional genomics screens was applied to provide …
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Call control signalling for personal communications over interconnected metropolitan area networks
… movements. A distributed personal communication network (PCN) based on the IEEE 802.6 metropolitan area networks (MANs) has been recently proposed as a means of supporting PCS. This network must be supported by efficient and reliable signalling, which has not been extensively examined and will be …
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Understanding Disease and Disease Relationships Using Transcriptomic Data
… In the next chapter, Using Dysregulated Signalling Paths to Understand Disease, gene expression changes are linked on the human signalling network, enabling identification of network regions dysregulated in disease. Applying this method across a large dataset of 141 common and rare …
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Investigating the role of ACSS2-mediated acetyl-CoA metabolism on EGFR-PI3K-PKB signalling
The epidermal growth factor receptor (EGFR) signalling network regulates growth, survival and differentiation in mammalian cells. There are multiple signalling pathways downstream of the EGFR, including the phosphoinositide-3-kinase (PI3K)-protein kinase B (PKB) pathway. This pathway is not only …
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BNC1 Regulates Human Epicardial Heterogeneity and Function
… in zebrafish and in neonatal mouse, epicardial signalling enables robust cardiac regeneration after myocardial infarction. We hypothesise that manipulating human epicardial function could facilitate heart regeneration, via reactivation of embryonic processes. However, epicardial regulation …
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