Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"signalling cascades"”.
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Role of phosphatases in controlling arabidopsis mapk signalling cascades
Plants possess integrated signalling networks that mediate the responses to various environmental conditions. Mitogen-activated protein kinases (MAPKs) constitute a highly conserved family of enzymes in eukaryotes, and in plants MAPK-based signal transduction modules regulate a large number of …
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Repulsive cues and signalling cascades of the axon growth cone
… data in the literature on Semaphorin-3A signalling, where differing labs had shown that inhibiting protein synthesis either blocks or has no effect upon repulsion. They demonstrate the presence of at least two independent pathways, protein synthesisdependent mTOR activation and …
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Defining the minimal and context-dependent signalling cascades regulating the maintenance of human naïve embryonic stem cells and early embryo development
… epiblast lineage. Whilst some of the signalling cascades that are fundamentally implicated in modulating the naïve gene regulatory network have been studied, our understanding of the finer details is incomplete. To date, the roles of the WNT signalling cascade remains a topic of …
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Role of Tumour Necrosis Factor Alpha (TNFa) in ischaemic and pharmacological postconditioning
… mechanism that activates prosurvival intrinsic signalling cascades to limit reperfusion injury but the exact signalling pathway involved in this cardioprotective effect still remains unclear.
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Characterization of Rapid Nongenomic Cortisol Signalling in Rainbow Trout Liver
… effects through genomic and nongenomic signalling pathways. The genomic response to cortisol is characterized by activation of the corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), whereas the nongenomic cortisol response involves rapid changes …
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P21- ACTIVATED KINASE 4 AND ACTIN CYTOSKELETON DYNAMICS
… IN THE ACTIN POLYMERISATION AND DEPOLYMERISATION CASCADES DOWNSTREAM SIGNALLING CASCADES, SUCH AS PAK4. THE FIRST OBJECTIVE WAS ACHIEVED BY CRYSTALLISING THE PAK4: INCA COMPLEX IN VIVO. THIS NOVEL STRUCTURE OF THE PAK4 KINASE DOMAIN IN COMPLEX WITH INCA AND ATP WAS SOLVED AT A RESOLUTION OF 2.95 …
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Identification and characterization of novel autoregulatory mechanism controlling ataxia telangiectasis mutated gene expression, protein traffiking and function
… after double stranded DNA damage and initiates signalling cascades that determine the process of decision-making of cell fate and involves the participation of multiple proteins. This vital protein acts first by sensing double stranded DNA breaks and second by transducing the signal and …
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Dissection of GnRH receptor-G protein coupling
… gonadotropes and activates Gq/11-mediated signalling pathways to stimulate the biosynthesis and the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH). Both GnRHs have also been suggested to inhibit cellular proliferation, an action which has largely been proposed to …
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The regulation of metabolic gene expression in human skeletal muscle by exercise: the influence of exercise intensity and contraction frequency
… stimulates a unique set of intracellular signalling cascades resulting in the activation of kinases which can subsequently control muscle metabolism. The signalling pathways involved are activated by alterations in ATP turnover, calcium flux, cellular stress and the redox state in the …
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Investigation of regulatory functions of micrornas in skin and hair follicle development and cycling. A role of microRNA-214 in skin and hair follicle homeostasis.
… essential components of Wnt, Edar, Shh and Bmp signalling pathways, whereas -catenin acts as a novel conserved miR-214 target. Indeed, the inhibitory effects of miR-214 on HF development were rescued by intracutaneous delivery of pharmacological Wnt activator. Thus, this study demonstrated that …
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Characterisation of HIF2A targets identifies MYC as a key determinant of HIF2A dependency in ccRCC
… RNA-seq uncouples direct targets from downstream signalling cascades. This unbiased method enabled the shortlisting of clinically relevant candidate HIF2A direct target genes which could then be functionally tested by *in vivo* CRISPR/Cas9 screening and subsequent rescue experiments. CRISPR/Cas9 …
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Regulation of blood platelet function by the AGC family of protein kinases
… the ectonucleotidase CD39. NO and PGI2 stimulate signalling cascades that result in the activation of the AGC family of Ser/Thr protein kinases (PKA, PKG and PKC). Once activated these kinase blunt platelet function through the phosphorylation of signalling proteins requested for activation. In …
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New signalling network in plant abiotic stress discovered through a genetic approach
… the interactive relationships between different signalling pathways triggered by the stress factors tested, indicating new features on the control of the expression of RCI2A. First, a novel cold-signalling pathway different to the CBF/DREB1-dependent pathway, was proposed to induce the expression …
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Synthesis of Hyaluronan by Tumour Cells – Mechanism and Implications
… connective tissues. It has both structural and signalling functions, triggering various cell signalling cascades, which result in adhesion, migration and invasion. It has been reported that Squamous Cell Carcinomas (SCC) of the skin, oesophagus, larynx and lung, initially experience an increase …
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The Development of Assays for Detecting Proximal Phosphorylation and Covalent Modification of Proteins
… including protein localization, degradation, signalling cascades, gene expression, and the cell cycle. Importantly, the dysregulation of proximal phosphorylation motifs has been implicated in aberrant protein states, including the overactivation of kinases in oncology and protein aggregation …
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The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells
… the tyrosine kinases JAK1 and JAK3 in cytokine signalling, focusing on interleukin-2 signalling in CD8<sup>+</sup> effector T lymphocytes. Initial experiments compared the effects of the pan JAK1/JAK3 inhibitor tofacitinib, the selective JAK1 inhibitor GSK186, and the selective JAK3 inhibitor …
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Investigation of the Anti-Proliferative and Pro-Apoptotic Effects of Rosemary (Rosmarinus officinalis) Extract on Androgen Independent Prostate Cancer Cells
… key proteins involved in apoptotic and survival signalling cascades. In our studies, RE inhibited the proliferation (IC50: 26 μg/mL; 70 μg/mL) and colony formation efficiency (IC50: 2.8 μg/mL; 4.8 μg/mL) of PC-3 and 22Rv1 prostate cancer cells, respectively, and enhanced cell death by stimulating …
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The role of chemokine receptor trafficking in regulating neutrophil migration to inflammatory sites
… (GPCRs) and initiate complex intracellular signalling cascades which ultimately result in directional neutrophil migration. Upon ligand binding, GPCRs can undergo multiple trafficking fates which may in turn influence sensitivity to the gradient. However, the functional significance of …
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Building and characterising the neuropeptidergic connectome of Caenorhabditis elegans
… the structure and function of extrasynaptic signalling networks at a whole-organism level. Here I present data and analysis for a whole-organism level map of neuromodulatory connections in C. elegans and the tools I developed to build and characterise it. Specifically, I focused on the …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
… genes might be regulated by well known p75NTR signalling cascades such as NF-κB or JNK signalling, which are independent of γ-secretase-mediated cleavage of the receptor. In contrast, while p75NTR overexpression was confirmed in melanoma cell lines and a patient sample of melanoma metastasis to …
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