Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 2395 for “"signalling"”.
-
Modelling religious signalling
… of religion and human social cooperation: the signalling theory of religion, or religious signalling theory (RST). According to the signalling theory, participation in social religion (and its associated rituals and sanctions) acts as an honest signal of one's commitment to a religiously …
-
Modelling religious signalling
… of religion and human social cooperation: the signalling theory of religion, or religious signalling theory (RST). According to the signalling theory, participation in social religion (and its associated rituals and sanctions) acts as an honest signal of one's commitment to a religiously …
-
Artificial Transmembrane Signalling
… proteins play a vital role in these signalling pathways. A large number of examples of synthetic membrane channels and transporters have been reported in the past four decades. However, signal transduction without mass transfer is considerably more challenging. In this dissertation, …
-
Nitrogen signalling in Arabidopsis thaliana
Nitrogen is an essential macronutrient for plants and nitrogen fertilizers are indispensable for modern agriculture. Unfortunately, we know too little about how plants regulate their use of soil nitrogen, to maximize fertilizers-N use by crops and pastures. This project took a dual approach, …
-
Presynaptic signalling in Huntington’s disease
… preclinical models. Crucially, members of BDNF signalling pathway regulate a form of presynaptic function called activity dependent endocytosis (ADBE) which is the dominant mode of endocytosis at the presynapse during high frequency stimulation. Previous work in this laboratory showed that ADBE …
-
BMP9 Signalling in Ovarian Cancer
… cancer. This thesis examines the role of BMP signalling in ovarian cancer using in vitro cancer cell models. It builds upon the initial published work by the Inman lab identifying autocrine BMP9 as a promoter of ovarian cancer cell proliferation. The findings of Chapters 3-5 provide strong …
-
Signalling to intracellular Ca2+ channels
… of cAMP to IP$_{3}$ receptors (IP$_{3}$R) within signalling junctions. My aim was to establish whether the interaction between adenylyl cyclase (AC) and IP$_{3}$R persists during sustained stimulation with PTH, which has been reported to cause internalization of a functional PTH$_{1}$R signalling …
-
Neuroepithelial Signalling in the Colon
… thesis sought to understand the contribution of signalling mediators and hormones of the gut mucosa to colonic sensory transduction. Selective TRPV4 agonist GSK1016790A was found to evoke a rapid and robust increase in colonic sensory afferent firing which was abolished upon the removal of the …
-
SUFU in SHH signalling mediated myogenesis
… development and involves a multitude of cellular signalling pathways. Among these include the Sonic hedgehog (Shh) signalling pathway which must be deactivated for differentiation into muscle cells to occur. However, less is known regarding the pathways operation during cell differentiation and …
-
Investigating WNT signalling in the lung
… As a branch of non-canonical WNT signalling, the planar cell polarity (PCP) pathway has emerged as a key ciliary signalling mechanism. Recent studies have highlighted the involvement of core PCP proteins in both ARPKD pathology and lung development and homeostasis. The aim of the …
-
Prolactin signalling in murine hair growth
… receptors (PRLR) on target organs and initiates signalling via a number of intracellular pathways including the JAK-Stat5b pathway. The role of this pathway in murine hair growth was investigated by (i) PRLR gene disrupted mice, (ii) altered circulating prolactin profiles and (iii) impaired PRLR …
-
MRGX1-TRPAI in inflammatory pain signalling
Painful stimuli are detected at the peripheral terminals of specialised primary sensory neurons known as nociceptors. Nociceptors detect noxious (painful) stimuli to evoke pain sensation via the activation of Transient Receptor Potential Ankyrin 1 (TRPA1). TRPA1 activity can be modulated by …
-
p38 MAPK Signalling in Endothelial Apoptosis
… in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. Doxorubicin (also called Adriamycin) is a …
-
Central vasopressin signalling and aggressive behaviour
Although many signalling molecules appear relevant to the production of complex behaviours, those that are important to the physiological regulation of behaviour, and so those that characterise individual styles of behaviour, are unknown. Vasopressin is the strongest candidate regulator of social …
-
Characterisation of CCaMK in symbiosis signalling
Many plants form important and beneficial symbioses with microbes including arbuscular mycorrhization and the legume-rhizobial interaction. The establishment of both these symbioses involves common genes which encode the Sym pathway proteins, of which calcium- and calmodulin-dependent protein …
-
Intracellular signalling by arachidonic acid metabolites
In intrauterine tissues, pro-inflammatory cytokines and prostaglandins (PGs) have been identified as key mediators in the maintenance of pregnancy and parturition. The rise in PGD2 detected in the amniotic fluid before labour prompted the research presented in this thesis which describes the …
-
Inflammasome signalling during Salmonella Typhimurium infection
… auto-inflammatory and auto-immune diseases. The signalling events leading to inflammasome assembly are poorly understood and the molecules involved in fine-tuning its activity are only beginning to be discovered. The aim of this thesis was to discover new molecules involved in inflammasome …
-
Angiotensin II signalling in sensory neurons
Angiotensin II (Ang II) is a peptide associated with the regulation of blood pressure, though the elevated presence of Ang II in the inflamed bowel – and other inflamed tissues – and the presence of receptors for Ang II on sensory neurons may point to additional roles in nociception in inflammatory …
-
FKBP14 in Notch Signalling and Drosophila Development
… exhibiting defects typical of loss of Notch signalling. FKBPs are highly conserved and involved in a wide array of biochemical processes including protein folding, assembly, and trafficking, yet they are non-essential in yeast and their role in development of multicellular organisms remains …
Page 1 of 120