Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"signaling systems"”.
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Mechanism and specificity of bacterial two-component signaling systems
Bacterial two component signaling (TCS) systems are the predominant means by which bacteria sense and respond to external signals. These systems represent a large family of paralogous proteins; often hundreds of the histidine kinase (HK) and response regulator (RR) pairs that make up a TCS system …
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OWSS And MIMO-STC-OFDM: Signaling Systems for the Next Generation of High Speed Wireless LANs
… OFDM with Multiple Input Multiple Output (MIMO) systems to create MIMO-OFDM systems. This dissertation presents two different basis technologies for the next generation of high speed WLANs: OWSS and MIMO-STC-OFDM. OWSS, or Orthogonal Wavelet Division Multiplexed - Spread Spectrum is a new class …
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Molecular Expression of Neuroprotective and Neurodestructive Signaling Systems Following Axotomy-Induced Target Disconnection: Relevance to ALS
<p>Amyotrophic Lateral Sclerosis (ALS) is the most common adult motoneuron (MN) degenerative disease. Discovery of a portion of familial cases with a mutation in the gene superoxide dismutase 1 (SOD1) gene led to the development of a transgenic mouse model. Pre-symptomatic SOD1 mice show no …
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Investigation of two-component signaling systems in Pseudomonas aeruginosa and their roles in the mucus barrier
… through which this occurs is via two-component signaling systems, which are typically comprised of a membrane-bound histidine kinase that senses external cues signals, and a cognate cytoplasmic response regulator that triggers changes in gene expression. The importance of these systems is …
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Models and analysis of yeast mating response : tools for model building, from documentation to time-dependent stimulation
Molecular signaling systems allow cells to sense and respond to environmental stimuli. Quantitative modeling can be a valuable tool for evaluating and extending our understanding of signaling systems. In particular, studies of the mating pheromone response system in yeast (Saccharomyces cerevisiae) …
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Guidance of Developing Motor Neurons into the Periphery
… MNs subtypes begins with Sonic Hedgehog (Shh) signaling in the spinal cord and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine axon trajectory. …
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Hyperinsulinemia and Hyperglycemia Contribute to Diabetic Complications Through Cytokine Resistance and Altered Macrophage Function
Disruption of the cytokine signaling systems responsible for regulating the inflammatory activity of macrophages and direct alterations in macrophage function due to exposure to the conditions of diabetes may play an integral role in the generation of diabetes-associated accelerated …
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The Effects of Alarm System Errors on Dependence: Moderated Mediation of Trust With and Without Risk
<p>Research on sensor-based signaling systems suggests that false alarms and misses affect operator dependence via two independent psychological processes, hypothesized as two types of trust. These two types of trust manifest in two categorically different behaviors: compliance and reliance. The …
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Influence of the members of Ras/PKA signal transduction pathway on the yeast Saccharomyces cerevisiae cell death induced by natural acidification of the medium /
… the course of evolution the cells have developed signaling systems that are able to combine extracellular signals with the inner processes, as transcription, translation etc. One of the universal signaling systems is Ras/PKA signal transduction pathway. This system helps cells recognize the …
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Input-output biomolecular systems
… reaction networks can be modeled as input-output systems, where the input, state and output variables are concentrations of the biomolecules involved in these reactions. Tools from non-linear dynamics and control theory can be leveraged to analyze and control these systems. In this thesis, we …
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the impact of Ape/Ref1 on hypoxia regulated genes; potential applications for cancer
… therefore critical. Reduction¿oxidation (redox) signaling systems are emerging as important targets in pancreatic cancer. AP endonuclease1/Redox effector factor 1 (APE1/Ref-1) is upregulated in human pancreatic cancer cells and modulation of its redox activity blocks the proliferation and …
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The interactive and individual effects of orexin A and neurotensin in the brain on spontaneous physical activity.
… feeding and locomotion circuits that feature the signaling of numerous peptides. Orexin A has been shown to have effects on feeding and physical activity behaviors when administered centrally or in several brain regions. This effect is site-specific and requires the presence of orexin receptors. …
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Additive effects among uterine paracrine factors in promoting bovine trophoblast cell proliferation
… proliferation, and to decipher the intracellular signaling mechanisms employed by these growth factors to regulate cell proliferation. Pilot studies established effective concentrations for each growth factor on a bovine trophoblast cell line (CT1). The first set of studies examined how each …
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Inflammatory mediators in diabetic retinopathy
… and oxidative stress, induction of inflammatory signaling systems and inflow of leukocytes, and ultimately altered gene transcription, in turn promoting the biomolecular DR characteristics. This thesis enlightens how established pathways may contribute to inflammation in DR and summarizes the …
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Behavioral and Reproductive Plasticity in Eastern Mosquitofish (Gambusia Holbrooki) in Response to Predatory Cues
… of predation risk. Many fishes possess alarm signaling systems, wherein an individual can detect injured conspecifics via olfaction and respond behaviorally to the presence of a predator. The superorder Ostariophysi exhibits a fright reaction to injured conspecifics, characterized by …
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Approaches towards development of novel fluorogenic biosensors for detection of small protein analytes
… orchestrated by a relatively small repertoire of signaling molecules, which mediate communication between cells. Breakdown of these communication pathways can have profound consequences, leading to a multiplicity of developmental defects and disease states. In particular, the ErbB family of …
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Functional Elucidation of The Adipokinetic Hormone/Corazonin Related Peptide and Insights into Its Receptor Specificity Using Receptor Chimera in Aedes Aegypti Mosquito
… hormone (AKH). A well-known function of the AKH signaling system is the mobilization of energy while CRZ was initially described as a cardioacceleratory factor. Contrastingly, the role of ACP and its receptor (ACPr) remains unclear in many insects. Despite the structural similarity and the close …
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Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… of bacterial defense mechanisms [1]. These systems are thought to have provided the evolutionary foundation for numerous eukaryotic immune strategies [2]. Experimental studies have validated many of these anti-phage defense systems and revealed the mechanisms by which they disrupt phage …
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Primordial imperatives and the evolution of control of endolysosomal trafficking
… MHC-II(Fairn and Grinstein, 2012) and cellular signaling systems such as insulin(Lodhi et al., 2008) and Wnt(Taelman et al., 2010). By examining the mechanisms of control in their evolutionary context, one gains a better understanding of a complicated cellular process underlying diseases such as …
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Modularity of signaling cycle architectures
… effect of retroactivity applied by downstream systems and hence facilitate modular design in synthetic biology. Phosphorylation cycles are ubiquitous in cell signal-transduction systems. Single phosphorylation cycles have been found to have insulating properties that reduce the effect of …
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