Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1026 for “"signaling pathways"”.
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Understanding Host Antiviral Signaling Pathways
… detect virally-derived nucleic acids and trigger signaling pathways which lead to the activation of transcription factors like nuclear factor-kappa B (NF-kappa B), interferon regulatory factor 3 (IRF3) and interferon regulatory factor 7 (IRF7). These transcription factors regulate the synthesis of …
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Ryanodine receptors in calcium signaling pathways
… the role of RyR<sub>2</sub> in Ca<sup>2+</sup> signaling in the NG115-401L neuronal cell line. siRNA transfection methods were employed to knockdown RyR<sub>2</sub> expression levels in NG115-401L cells. We used reverse transcription and real-time PCR to evaluate RyR2 gene expression in …
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Central signaling pathways in chemotactic signaling
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Optogenetic control of developmental signaling pathways
… programs use a surprisingly small set of signaling pathways to pattern the embryonic tissue into germ layers from which the various tissues and organs emerge. A hallmark of embryonic development is that these recurring developmental signaling pathways are carefully orchestrated in space …
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Developmental signaling pathways in adult energy homeostasis
Many signaling pathways which are classically understood for their roles in early development are also known to be involved in tissue maintenance and adult energy homeostasis. Furthermore, dysfunction of these signaling pathways results in human diseases such as cancer. An in depth understanding of …
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Regulation of CaMKKβ Dependent Signaling Pathways
… kinase (AMPK) in a number of physiological pathways including learning and memory formation, neuronal differentiation, and regulation of energy balance. The purpose of the work presented in this dissertation is to better understand the regulation of CaMKKβ activity and specificity in …
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Bayesian network models of biological signaling pathways
… and process cues from their environment, via signaling pathways, in which extracellular cues trigger a cascade of information flow, causing signaling molecules to become chemically, physically or locationally modified, gain new functional capabilities, and affect subsequent molecules in the …
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Analysis of phytochrome signaling pathways in Zea mays
… that mediate red and far-red light signaling and control growth and development of plants in response to different light conditions. The genome of Arabidopsis, a dicot, contains five members of the phytochrome family, phyA-phyE. In contrast, genomes of monocots sequenced so far …
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Architecture and evolutionary stability of yeast signaling pathways
… that, because the pheromone and HOG response pathways share protein components, selection for HOG function will enrich a population for cells capable of pheromone response. I performed experiments in both continuous and batch culture to demonstrate this effect. I then characterized the decay …
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Reconstructing Signaling Pathways Using Regular-Language Constrained Paths
Signaling pathways are widely studied in systems biology. Several databases catalog our knowledge of these pathways, including the proteins and interactions that comprise them. However, high-quality curation of this information is slow and painstaking. As a result, many interactions still lack …
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Signaling pathways regulating skeletal muscle metabolism and growth
Skeletal muscle can perceive cellular energy status and substrate availability and demonstrates remarkable plasticity in response to environmental changes. Nonetheless, how skeletal muscle and its resident stem cells (satellite cells; SCs) sense and respond to nutrient flux remains largely …
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HORMONE AND FLAVONOL REGULATION OF MAMMALIAN METABOLIC SIGNALING PATHWAYS
… and T2DM are linked to altered peptide hormone signaling, including insensitivity to insulin and leptin. Research in this dissertation investigated how gender, weight loss, and diet components affected signaling pathways that are dysregulated in obesity and T2DM. Chapter II examined the effects …
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Novel small molecules for modulation of bacterial signaling pathways
… of novel QS inhibitors based on common QS signaling molecules, such as N-acylated L-homoserine lactones (AHLs), indoles, N-acetyl glucosamine and other heterocyclic systems derived from halogenated furanones (Fimbrolides). Indole and glucosamine-based amides and oxo-amides were synthesized …
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The role of mechanical loading in chondrocyte signaling pathways
… loading trigger differential intracellular signaling pathways at sub-cellular levels, which consequently lead to selective matrix synthesis and degradation. Furthermore, it is not known whether the loading-magnitude dependent responses are linked to degenerative diseases such as OA.</p> …
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BMPR2 and mTOR Signaling Pathways in Inflammatory Lung Diseases
… and the mammalian target of rapamycin (mTOR) signaling pathways in the pathogenesis of PAH and asthma, respectively. Previous studies have indicated mutations in BMPR2 as one of the contributing factors in the pathogenesis of the heritable form of PAH. Although BMPR2 mutations have been …
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Engineering orthogonal signaling pathways to probe sequence space capacity
… and powerful mechanism by which cells create new signaling pathways, but recently duplicated proteins typically must become insulated from each other, and from other paralogs, to prevent unwanted cross-talk. A similar challenge arises when new sensors or synthetic signaling pathways are engineered …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… of calcineurin and other calcium-regulated signaling pathways in the control of myofiber specialization. By analyzing two fiber type-specific enhancers, I was able to demonstrate that there are functional NFAT (nuclear factor of activated T cells) and MEF2 (myocyte-specific enhancer factor …
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Pathogen-Specific Adaptations to Conserved Signaling Pathways in Cryptococcus neoformans
… conserved eukaryotic and fungal-specific signaling pathways to sense and respond to stresses within the host. Upon infection, two of the most significant environmental changes this organism experiences are elevated temperature and high pH. </p><p>Conserved Rho and Ras family GTPases are …
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Activation of developmental signaling pathways in hematopoietic stem cell regeneration
… of this project it was unclear whether the signaling pathways which homeostatically control self renewal are utilized during injury repair. In particular, there is very little understanding of the signals required for regeneration after radiation damage. We hypothesized extracellular signal …
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