Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 273 for “"signaling molecules"”.
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Biochemical and single-molecule analysis of signaling molecules
Made available in DSpace on 2015-09-29T21:03:05Z (GMT). No. of bitstreams: 2 ARAUZDIAZ-DISSERTATION-2015.pdf: 32102704 bytes, checksum: 0fac2e8bc8c2b7f7e03d048995063155 (MD5) LICENSE.txt: 4213 bytes, checksum: bc7dfce6ff47d6f1369138bc730d1c6f (MD5) Previous issue date: 2015-07-14
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Regulation and production of extracellular signaling molecules in Bacillus subtilis
… B. subtilis produces a putative interspecies signaling activity, AI-2, that depends on the conserved protein LuxS. To determine the effect of luxS on regulation of transcription in B. subtilis, I performed experiments to compare the transcriptional profiles of B. subtilis when luxS was deleted …
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Mass spectrometry-based characterization of cell-to-cell signaling molecules in the nervous system
Cell-to-cell signaling molecules are an important class of endogenous molecules which are responsible for cell-to-cell communication within organisms. Small molecules and peptides work as neurotransmitters and neuromodulators in the nervous system and play important regulatory roles in a wide range …
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Synthesis of Small Molecule and Polymeric Systems for the Controlled Release of Sulfur Signaling Molecules
… sulfide (H₂S) was recognized as a critical signaling molecule in mammals nearly two decades ago. Since this discovery biologists and chemists have worked in concert to demonstrate the physiological roles of H₂S as well as the therapeutic benefit of exogenous H₂S delivery. As the …
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Amino acid racemase responsible for the biosynthesis of D-aspartate and D-serine signaling molecules in Aplysia californica central nervous system
… research interests because of their cell-cell signaling functions in animal nervous systems. D-serine (D-Ser) can affect the activity and plasticity of N-methyl-D-aspartate (NMDA) receptor, a molecule that forms the basis of learning and memory in the brain. D-aspartate (D-Asp) is found in …
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Shaping spatial and temporal gradients during the development of Caenorhabditis elegans : an antagonistic balance
… is to form spatial or temporal gradients of signaling molecules, which patterns tissues in a concentration-dependent manner. A critical challenge of such gradient based patterning mechanisms is to maintain the desired gradient profiles of signaling molecules in a heterogeneous and fluctuating …
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Rapid molecular signature analysis of pseudomonas aeruginosa by direct nanomolar detection of quorum sensing and biomarker molecules at a boron-doped diamond electrode
… and sensitive method for the detection of biomolecules as indicators of Pseudomonas aeruginosa infection. This is of significant clinical importance for patients with cystic fibrosis (CF) of which Ireland has one of the highest rates in the world per head of population. Cell-to-cell …
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The low-level light therapy affects human dermal fibroblast via TGF-β/smad signaling pathway: in vitro study
… on the expression of mRNA of TGF-ß/smad signaling molecules 9 C. The effect of LLLT on the protein expression of TGF-ß/smad signaling molecules 12 D. Protein expression of collagen type I, TGF-ß1, smad3 and smad7 after incubation with exogenous TGF-ß1 13 IV. DISCUSSION …
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Biochemical Characterization of Arabidopsis Enzymes Involved in Inositol Pyrophosphate Biosynthesis
… led to the development of many sophisticated signaling pathways that help plants sense and respond appropriately to different environmental cues. One such signaling pathway is called inositol phosphate signaling. This research dissertation focuses on the inositol phosphate signaling pathway in …
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Synthesis and biological research of the pseudomonas aeruginosa signaling compounds PQS and N-3-oxo-dodecanoyl-L-homoserine lactone
… chronic infections, the Pseudomonas aeruginosa signaling molecules 3-oxo-C12-homoserine lactone and Pseudomonas quinolone signal were synthesized so that the mammalian cellular responses to their presence via an infection could be studied. It was hypothesized that differing combinations of the …
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Bayesian network models of biological signaling pathways
… and process cues from their environment, via signaling pathways, in which extracellular cues trigger a cascade of information flow, causing signaling molecules to become chemically, physically or locationally modified, gain new functional capabilities, and affect subsequent molecules in the …
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
… MMTV integration site (Wnt) is well known signaling molecules that implicated in mesenchymal differentiation during development, but the role in proliferation of hMSCs is not well known. In this study, we investigated the effect of Wnt signaling molecules on the proliferation of hMSCs. The …
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Markov random field modeling of the spatial distribution of proteins on cell membranes
… of receptors that bind ligands and activate signaling pathways. Signaling is characterized by dramatic changes in membrane molecular topography, including the co-clustering of receptors with signaling molecules and the segregation of other signaling molecules away from receptors. Electron …
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Investigation of the anti-cancer effects of rosemary (Rosmarinus Officinalis L.) extract in human breast and prostate cancer cells
… new approaches, including identifying specific signaling molecules that are overactivated and could be targeted, are required to effectively treat this subtype of prostate cancer. Rosemary extract (RE) has been shown to have anti-cancer properties in vitro and in vivo. However, limited evidence …
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Physiological and cellular characterization of a plant natriuretic peptide
… capacity to survive. Plants can use multiple signaling pathways and signals to mediate their response; for example, at least four different signal pathways have been identified for water-deficit stress (Shinozaki and Yamaguchi-Shinozaki, 1997; Xiong et al., 2002). Different forms of stress may …
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Interleukin-10 Suppresses Mast Cell IgE Receptor Expression And Signaling In Vitro And In Vivo
… of FcεRI expression and related downstream signaling molecules, and to determine how this affects mast cell function in vitro and in vivo.Methods: Mast cell FcεRI expression was evaluated with and without IL-10 treatment in human lung and skin mast cells, and on peritoneal mast cells from …
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… stimuli used. After insulin stimulation insulin signaling molecules such as protein kinase B (PKB) are associated with PDE3B in the large complex while after catecholamine stimulation adrenergic signaling molecules such as protein kinase A (PKA) are associated with PDE3B.
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Towards brain-wide noninvasive molecular imaging
An intricate interplay of signaling molecules underlies brain activity, yet studying these molecular events in living whole organisms remains a challenge. Magnetic resonance imaging (MRI) is the most promising imaging modality for development of molecular signaling sensors with deeper tissue …
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Mass spectrometry-based identification and quantitation of endogenous peptides in complex biological matrices
In the brain, chemical signaling molecules transfer information from cell-to-cell to modulate mood, behavior, and physiological functions like metabolism and circadian rhythm. The research presented in this dissertation is focused on characterizing a specific class of signaling molecules, …
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