Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 109 for “"signaling molecule"”.
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Structural and chemical studies of RNA as anti-cancer target and signaling molecule
… to inhibit telomerase in order to obtain a molecule which was a better inhibitor of telomerase than naproxen alone. The final portion of the dissertation deals with identifying and targeting extracellular microRNA released from cancerous cells. MicroRNA are small (22-25 nucleotides) RNA …
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Analysis of D-Aspartate as a Signaling Molecule in the Aplysia Californica Central Nervous System Using Capillary Electrophoresis and Radioisotopic Labeling
A second cell-cell signaling molecule investigated is D-aspartate (D-Asp). D-Asp is present in the nervous systems of both vertebrates and invertebrates, and its biosynthesis has been observed in mammalian cells. We suspect that D-Asp acts as a classical neurotransmitter in the central nervous …
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Insulin Modulates Synaptic Transmission and AMPA Receptor Trafficking Via Insulin Receptor Signaling Molecule In Region CA1 of the Juvenile and Mature Hippocampuss
… and studied the role of insulin receptor signaling in insulin-LTD. My data revealed that insulin caused LTD in region CA1 of juvenile, but not mature rats. Furthermore, I observed age-dependent differences in insulin stimulated phosphorylation of Akt (pAkt) and p44/42MAP kinase (Pp44/42). …
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Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… recognition event triggers the production of a signaling molecule that activates the depletion of an essential metabolite, limiting viral propagation. The second discovery demonstrated that cyclic oligonucleotide-based antiphage signaling systems (CBASS) recognize infection through the …
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Biochemical Assay Optimization and Computational Screening Efforts to Identify Potential LuxS Inhibitors
… System two QS is regulated by the small signaling molecule autoinducer-2 (AI-2) and is implicated in the infectious behaviors of various bacterial species. AI-2 is biosynthesized from <em>S-</em>ribosylhomocysteine (SRH) by the enzyme LuxS and induces interspecies cell-to-cell …
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Quantitative measurement and modeling of the DNA damage signaling network : DNA double-strand breaks
… what "formula" a cell uses to integrate protein signaling molecule activities to determine which of these paths it will take, or what protein signaling-molecules are essential to the execution of that decision. A better understanding of how these cellular decisions are made and mediated on a …
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Synthesis of Small Molecule and Polymeric Systems for the Controlled Release of Sulfur Signaling Molecules
… sulfide (H₂S) was recognized as a critical signaling molecule in mammals nearly two decades ago. Since this discovery biologists and chemists have worked in concert to demonstrate the physiological roles of H₂S as well as the therapeutic benefit of exogenous H₂S delivery. As the …
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Salivary Reduction of Dietary Nitrate
Nitric oxide (NO) is an important cellular signaling molecule known mostly for its vasodilatative effects. Nitrate (NO3-) acts as an important NO source through reductive physiological pathways. Basal plasma NO3- levels are a sum of the oxidation of endogenous NO and ingested dietary NO3-. …
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The Effect of impaired Cyclooxygenase 2 activity on gene regulation in the developing mouse brain and the role of PGE2 in oxidative stress production in Differentiated Neuronal Cells
Prostaglandin E2 (PGE2) is a signaling molecule derived from the lipid membrane through the enzyme cyclooxygenase2 (COX-2). These studies aim to investigate how changes in COX-PGE2 signalling can influence mouse gene expression and alter oxidative stress in neuronal cells. In study 1 we use …
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Peroxisome Proliferator -Activated Receptor (Ppar)alpha Regulation of Highly Unsaturated Fatty Acid Synthesis
… by EFA deficient diets. LysoPL may act as signaling molecule and activate PPARalpha in response to essential fatty acid deficiency.
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Characterization of Endothelial Nitric Oxide Synthase Serine-600 Phosphorylation
… nitric oxide (NO). NO is a gaseous, free-radical signaling molecule that has a variety of cellular and physiological functions that range from maintaining cardiovascular homeostasis to neurotransmission. The function of NO greatly depends on the concentration and is cell type specific. eNOS is the …
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The role of ras signaling associative learning and memory in Drosophila
Ras is an evolutionally conserved signaling molecule that has been implicated in a variety of cellular events, such as cell proliferation, differentiation, and survival. Recent studies also suggest roles of Ras in neuronal plasticity. I investigated the role of Ras in associative learning and …
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Characterization of CPG15 during cortical development and activity dependent plasticity
… that cgp15, a gene encoding an extracellular signaling molecule that promotes dendritic and axonal growth and synaptic maturation, is regulated in the somatosensory cortex by sensory experience capable of inducing cortical plasticity. Using in situ hybridization, we monitored cgp15 expression …
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The application of signaling networks to cancer metastasis and cellular motility through the EGFR pathway
… consists of partial differential equations and signaling networks. Analysis techniques for these nonlinear reaction-diffusion equations included a study of the biological background and motivation, along with computational simulation of the various sets of models developed. The modeling effort …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
… (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the wingless signaling pathway and …
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The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
… (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the wingless signaling pathway and …
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Nox4 mediates metabolic stress responses
… produces hydrogen peroxide (H2O2), an effective signaling molecule. Here we demonstrate an essential role for Nox4 in mediating the beneficial effects of exercise. This work will contribute to our understanding of physiological ROS and their downstream targets by identifying a novel role for Nox4 …
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Studying the Competence Regulon Quorum Sensing Circuity in Streptococcus mitis
… QS bacteria generate and release chemical signal molecules known as autoinducers, which increase in concentration as cell density increases. To determine the cell density and initiate the group behaviors such as virulence factor production, biofilm formation, and competence development bacteria …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… as learning and memory. Due its importance as a signaling molecule, the extracellular glutamate concentration is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these studies, we investigated the role of EAAT1-3 in synaptic transmission at the Schaffer-CA1 synapse …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… as learning and memory. Due its importance as a signaling molecule, the extracellular glutamate concentration is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these studies, we investigated the role of EAAT1-3 in synaptic transmission at the Schaffer-CA1 synapse …
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