Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 60 for “"signaling mechanism"”.
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HAMP Domain and Signaling Mechanism of the Aer Protein
… FI fragment in the N terminus and a chemotaxis signaling domain in the C terminus, separated by a putative transmembrane region. In this dissertation, I report that the linker region of Aer (residues 205-265), which joins the transmembrane region to the signaling domain, is a conserved signal …
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Mismatch Repair Protein-Dependent Cytotoxic Signaling In Cells Treated With The Cancer Chemotherapeutic Cisplatin
… to CDDP; as such, a clear understanding of the mechanisms of CDDP-induced, MMR protein-dependent cell death is critical. This study demonstrates a CDDP-induced pro-death signaling mechanism which is dependent upon the MMR proteins MSH2 and MSH6. This signaling mechanism employs the tyrosine …
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Information Design for Platform-Enabled Operations
… players (agents). Codified through a ``signaling mechanism", the informed player can design distributions over informative signals to reveal depending on the value of the uncertain random variable. Through the design of the signaling mechanism, a planner can affect the agents' posterior …
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PAS Signaling Mechanisms in Aer and Aer2
… raise the possibility of two different PAS-HAMP signaling mechanisms: a lateral PAS-HAMP signaling mechanism for Aer, and a linear PAS-HAMP signaling mechanism for Aer2. This dissertation focuses on uncovering the PAS-HAMP transduction mechanisms and clarifying the signaling of conserved residues …
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Essays on the relation between managers' incentives and financial accounting information
… and investors are more likely to use this signaling mechanism, and the capital market recognizes the information content of the earnings management activities and rationally incorporates it in setting prices.
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Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
… to infection in burn-injured mice; however, the mechanisms of these responses are not entirely known. Moreover, after burn injury, bacteria and their products leak out of the intestinal lumen and into the bloodstream. These bacteria can disperse throughout the body leading to pulmonary damage, …
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Molecular Investigations of Protein Assemblies Involved in Prokaryotic Virulence
… in prokaryotic cells, yet the exact molecular mechanisms explaining how many of these complexes assemble and function remain unknown. This work focuses on understanding the molecular mechanisms of two different protein assemblies responsible for regulating virulence in the opportunistic …
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Repression and international conflict
… their international bargaining power through a signaling mechanism. The argument implies that governments continue to use repression because it can increase their power vis-a-vis both domestic and international opponents. With a global dataset on torture, death, disappearance, arbitrary arrests …
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Human Rights Signaling and Foreign Direct Investments After Civil Wars
… the wake of civil wars and how they serve as a signaling mechanism to Foreign Direct Investors (FDIs) about a country’s internal stability and environment for investments. I argue that signals are particularly salient in the information-poor environment that follows immediately after the civil …
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Mechanically-Induced Osteocyte-Th17-Cell Signaling and Osteoclastogenesis
… to prevent accumulation of microdamage, a repair mechanism known as targeted bone remodeling removes the damaged bone tissue and replaces it with new bone matrix.|Osteocyte apoptosis has been associated with fatigue induced microdamage, and the localization of bone resorbing osteoclasts. However, …
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Link Establishment in Ad Hoc Networks Using Smart Antennas
… effect of using smart antennas and proposes a signaling mechanism for forming the extended links using the network layer. For the performance assessment of the wireless networks using directional antennas, baseline models of phased array antenna and channel have been developed using the …
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Structural and Functional Studies of Sensor Kinase RetS from Pseudomonas aeruginosa and Peptidoglycan Hydrolase SleB from Bacillus anthracis
Part I: Signaling Role of the Sensor Kinase RetS in Biofilm formation Regulation of Pseudomonas aeruginosa-<br />The opportunistic human pathogen Pseudomonas aeruginosa causes both acute and chronic infections in predisposed individuals. Acute infections require a functional Type Three Secretion …
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Molecular Dynamics Simulation of Force-Induced Protein Domain Unfolding
… is a molecular recognition switch, a novel signaling mechanism, in extracellular matrix protein fibronectin.
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Structural Studies on the Regulation of Sporulation in Bacillus and Antibiotic Sulfation
… with complexity. Bacteria have evolved several mechanisms to help them survive the harshest environments on earth. These range from complex developmental transformations to the synthesis of small molecule antibiotics that can fend off competing species. Both of these topics will be the focus of …
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BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS
… of the Mitogen-Activated Protein Kinase (MAPK) signaling pathway proteins, ERK1/2. This effect was mediated by rBsg-ECD binding to the Basigin-2 (Bsg-2) at the cell surface. In this research, U87-MG human GBM cells were treated with purified rBsg-ECD protein to measure changes in the …
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Investigating the Post-Translational Modification of Notch1 Intracellular Domain: From Proteolytic Cleavage to Mass Spectrometric Profiling
The Notch signaling pathway is a highly conserved cell-to-cell contact dependent signaling mechanism that plays a pivotal role in cell fate determination, cellular development and its dysregulation has been widely associated with cancer. Thus, post-translational modifications (PTM) further …
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BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex
… synapses has been extensively studied, the mechanisms underlying the formation of the tripartite synapse remain poorly understood. The tripartite synapse is a specialized structure consisting of the presynaptic terminal, the postsynaptic element, and a perisynaptic astrocyte process (PAP) …
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Independence and interdependence: signal transduction of two chemosensory receptors important for the regulation of gliding motility in Myxococcus xanthus
… whether DifA shares similar transmembrane signaling mechanism with typical transmembrane sensor proteins (MCPs and sensor kinases), we constructed a chimeric protein that is composed of the N-terminus of NarX (nitrate sensor kinase) and the C-terminus of DifA. This NarX-DifA chimera …
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Innate Immune Sensing and Signaling of Cytosolic DNA
… Together, these results not only elucidate the mechanism of cytosolic DNA sensing, but also uncover a novel second messenger-mediated signaling mechanism in innate immunity.
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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
… As a result, investigations of PM-induced mechanisms of toxicity have grown in kind. Despite this effort the putative mechanisms that underlie CVD and exposure to PM remain elusive. We set out to explore the potential mechanisms that result in cross-talk between the pulmonary and …
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